# Lancôme Advanced Génifique Youth Activating Concentrate for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Lancôme](https://lovi.care/skincare/ca/brands/lancome)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your combination skin, as bifida ferment lysate and glycerin support barrier repair and hydration, but it does not directly target your oily shine concern.
- Adenosine provides some anti-aging effects, which is a general skincare benefit that complements your skin type.
- The formula is safe for your combination skin, with no harsh ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/oily-acne-prone-skin): Average

## Key ingredients

Bifida Lysate Ferment, Sodium Hyaluronate, Ascorbyl Glucoside, Adenosine, Caprylyl Glycol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- A preservative system containing 1,2-hexanediol and caprylyl glycol showed no delayed Type IV dermal sensitivity reactions in 200 subjects when tested as a 15% mixture in carbomer gel and in a cosmetic formulation. ([Cutaneous and Ocular Toxicology, 2009](https://pubmed.ncbi.nlm.nih.gov/19514921/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures. ([The Journal of Investigative Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17301835/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Based on a very large amount of data, users love this serum's lightweight, fast-absorbing texture that provides immediate hydration and a noticeable glow without stickiness. Many report smoother skin and reduced fine lines quickly. Some users, particularly those with sensitive skin, experienced breakouts, and a number found the high price point not justified by the anti-aging results.

- Liked: Improves skin texture (mostly mentioned)
- Liked: Boosts radiance (often mentioned)
- Liked: Fast absorption (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Smart packaging (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Disliked: Alcohol content (rarely noted)
- Disliked: Caused breakouts (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Lancôme Advanced Génifique work for combination skin?

This treatment works reasonably well for combination skin, as it helps repair the skin barrier and keeps the skin hydrated while remaining safe and gentle, though it does not directly target oily shine. To work best for this skin type, a product needs ingredients like niacinamide, zinc PCA, or propolis that help control excess oil and enhance radiance without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Cutaneous and Ocular Toxicology, 2009](https://pubmed.ncbi.nlm.nih.gov/19514921/)

### Which ingredients make this serum a good fit for combination skin?

Bifida ferment lysate, glycerin, and sodium hyaluronate help support barrier repair and hydration for your combination skin. To make a treatment of this type a better fit for this skin type, it needs ingredients like niacinamide, zinc PCA, or propolis to help manage oily shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Bifida Ferment Lysate do for combination skin?

Bifida Ferment Lysate helps strengthen the skin barrier and calm irritation, making it a good fit for combination skin that is prone to sensitivity. This ingredient works by supporting the skin defenses, keeping moisture locked in, and helping to reduce redness.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after your cleansing toner and before your moisturizer. It is safe for your skin type, though combination skin also needs ingredients that directly target oily shine.

### Can I use this serum with retinol, and in what order?

Yes, you can use this treatment with retinol by applying the serum first and following it with your retinol product. This helps keep your skin soft and hydrated while minimizing the risk of irritation, as the formula is safe and gentle for combination skin.

### How often should I use this serum?

This treatment is used in the evening routine. A product of this type for combination skin needs ingredients that also help control oily shine and balance moisture.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause breakouts for combination skin, as it has a very low complaint rate for causing blemishes and contains no harsh ingredients that typically trigger irritation. It helps keep skin feeling comfortable and balanced without heavy pore-clogging elements.
Sources: [Cutaneous and Ocular Toxicology, 2009](https://pubmed.ncbi.nlm.nih.gov/19514921/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (limonene and citronellol) and drying alcohol (alcohol denat).

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/combination-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/combination-skin) — Average fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Amazon.ca: CA$270.00 (https://www.amazon.ca/dp/B081CJ98TR?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Bifida Lysate Ferment, Glycerin, Alcohol Denat, Dimethicone, Hydroxyethylpiperazine Ethane Sulfonic Acid, Ascorbyl Glucoside, Sodium Hyaluronate, Sodium Hydroxide, Sodium Benzoate, Phenoxyethanol, Adenosine, Faex Yeast Extrait De Levure Extract, Peg-20 Methyl Glucose Sesquistearate, Peg-60 Hydrogenated Castor Oil, Salicyloyl Phytosphingosine, Ammonium Polyacryldimethyltauramide Ammonium Polyacryloyldimethyl Taurate, Limonene, Xanthan Gum, Caprylyl Glycol, Disodium Edta, Octyldodecanol, Citronellol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin
- France: https://lovi.care/skincare/fr/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/lancome/advanced-genifique-youth-activating-concentrate/for/combination-skin