# La Roche-Posay Pure Niacinamide 10 Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/ca/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [La Roche-Posay](https://lovi.care/skincare/ca/brands/la-roche-posay)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- This serum offers moderate brightening and smoothing for your normal skin, with niacinamide and phenylethyl resorcinol working to even skin tone and improve texture.
- While sodium hyaluronate provides hydration beneficial for your wrinkles and fine lines, the formula lacks specialized ingredients to directly target them.
- The product is generally safe for your normal skin, though alcohol denat and fragrance may pose a slight risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/la-roche-posay/pure-niacinamide-10-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/la-roche-posay/pure-niacinamide-10-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/ca/p/la-roche-posay/pure-niacinamide-10-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/la-roche-posay/pure-niacinamide-10-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/la-roche-posay/pure-niacinamide-10-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/la-roche-posay/pure-niacinamide-10-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/la-roche-posay/pure-niacinamide-10-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/la-roche-posay/pure-niacinamide-10-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Thermal Water, Sodium Hyaluronate, Phenylethyl Resorcinol, Glycerin

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Nano-microneedle-assisted phenylethyl resorcinol significantly reduced the melanin index in infraorbital dark circles compared to baseline and topical-only treatment in 20 female participants without serious adverse effects. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32783330/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for its ability to fade dark spots and improve skin texture, leaving skin feeling hydrated and plump. Many users with sensitive skin find it gentle. A significant number of reviewers dislike the strong floral fragrance and find the dropper bottle design inconvenient. Some users have experienced breakouts or pilling, and many note that the product is now discontinued or difficult to find.

- Liked: Hydrating and plumping (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: Strong floral scent (often mentioned)
- Liked: Absorbs quickly (sometimes noted)
- Liked: Gentle on sensitive skin (sometimes noted)
- Disliked: Discontinued product (sometimes noted)
- Disliked: Messy dropper bottle (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Pilling issues (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does La Roche-Posay Pure Niacinamide 10 Serum work for mature skin?

This serum works moderately well for mature skin, offering some brightening and smoothing, though it lacks specialized ingredients to directly target fine lines and wrinkles. To truly fit mature skin, a product of this type needs exceptional safety without irritation risk, powerful anti-aging components like peptides, and rich hydrating ingredients that improve elasticity and smooth wrinkles.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32783330/)

### Which ingredients make this serum a good fit for mature skin?

Niacinamide and phenylethyl resorcinol help brighten and smooth mature skin, while sodium hyaluronate provides helpful hydration for lines and wrinkles. However, a product for this skin needs high-quality ingredients that effectively target wrinkles, antioxidants, skin-repairing components, peptides, and no risk of irritation.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32783330/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Thermal Water do for mature skin?

Thermal water helps calm and soothe the skin while strengthening its natural barrier against daily environmental stress. It is unlikely to irritate mature skin and may help keep it comfortable and resilient.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2011](https://pubmed.ncbi.nlm.nih.gov/21175867/), [Journal of the European Academy of Dermatology and Venereology, 2022](https://pubmed.ncbi.nlm.nih.gov/34979589/)

### Where does this serum go in a skincare routine for mature skin?

Apply this treatment in the evening as part of your routine for simplicity and extra safety around sun exposure. To properly care for mature skin, a product of this type needs specialized ingredients like retinol, peptides, or antioxidants to directly target wrinkles, fine lines, and firmness.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol product. When caring for mature skin, a product of this type needs specialized ingredients that directly target wrinkles and fine lines, along with soothing agents to keep dry skin calm.

### How often should I use this serum?

Use this serum in the evening. Mature skin needs products with powerful firming ingredients and rich moisturizers to smooth lines and keep skin soft.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin. While it is generally safe, any new product carries a slight risk of irritation or breakouts.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol denat).

## Alternatives for mature skin

- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/mature-skin) — High fit — CA$27.99 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/mature-skin) — High fit — CA$14.40 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin) — High fit — CA$24.44 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ca/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — CA$31.98 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — CA$103.73 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Niacinamide, Glycerin, Alcohol Denat, Hydroxyethylpiperazine Ethane Sulfonic Acid, Dimethicone, Isopropyl Lauroyl Sarcosinate, Octyldodecanol, Peg-20 Methyl Glucose Sesquistearate, Tin Oxide, Sorbitan Oleate, Dimethiconol, Cetearyl Ethylhexanoate, Isohexadecane, Sodium Hyaluronate, Phenylethyl Resorcinol, Poloxamer 338, Ammonium Polyacryloyldimethyl Taurate, Disodium Edta, Isopropyl Myristate, Citric Acid, Xanthan Gum, Polysorbate 80, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, Tocopherol, Phenoxyethanol, Mica, Ci 77891, Titanium Dioxide, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin (this page)
- Australia: https://lovi.care/skincare/au/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/la-roche-posay/pure-niacinamide-10-serum/for/mature-skin