# La Roche-Posay Effaclar H Iso-Biome Moisturiser for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [La Roche-Posay](https://lovi.care/skincare/ca/brands/la-roche-posay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your combination skin, this moisturizer effectively addresses oily shine with niacinamide and capryloyl glycine to regulate sebum production, while glycerin and panthenol provide excellent hydration and support barrier resilience.
- The formula is safe for your combination skin, containing no harsh ingredients that would cause irritation.
- This product offers moderate benefits for your oily shine and combination skin concerns.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/oily-acne-prone-skin): High

## Key ingredients

Thermal Water, Niacinamide, Squalane, Panthenol, Vitreoscilla Ferment

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- A dermocosmetic formulation containing Vichy volcanic mineralizing water, Vitreoscilla filiformis extract, niacinamide, hyaluronic acid, and vitamin E accelerated skin renewal, improved antioxidant defenses, enhanced skin barrier recovery after acute stress, and improved microbiome recovery compared to untreated skin. ([Journal of the European Academy of Dermatology and Venereology, 2022](https://pubmed.ncbi.nlm.nih.gov/34979590/))
- The combination of Vitreoscilla filiformis extract and Vichy volcanic mineralizing water strengthens the skin barrier by stimulating skin differentiation and tight junctions, enhances biochemical defenses via antimicrobial peptides, and supports cellular immune defenses by increasing the IL-10/IL-12 ratio and protecting Langerhans cells from ultraviolet radiation compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2022](https://pubmed.ncbi.nlm.nih.gov/34979591/))

## What reviewers say

This moisturizer is frequently described as a lifesaver for oily, acne-prone skin, especially when weakened by treatments. Most users find it deeply soothing and non-greasy, though a notable number report issues with pilling or the product rolling off the skin, particularly under makeup.

- Liked: Soothing for compromised barriers (mostly mentioned)
- Liked: Gentle on sensitive skin (often mentioned)
- Liked: Non-greasy hydration (often mentioned)
- Disliked: Pilling and flaking (often mentioned)
- Liked: Reduces acne/blemishes (sometimes noted)
- Disliked: Inferior to old formula (sometimes noted)
- Disliked: Not moisturizing enough (sometimes noted)
- Disliked: Small size / High price (sometimes noted)
- Disliked: Stinging sensation (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Effaclar H Iso-Biome Moisturiser a great fit for combination skin?

La Roche-Posay Effaclar H Iso-Biome Moisturiser is a great fit for your combination skin because it helps manage oily shine with niacinamide and capryloyl glycine while keeping your skin hydrated with glycerin and panthenol. Its gentle formula is unlikely to cause irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this cream a good fit for combination skin?

This cream is a great fit for your combination skin because niacinamide and capryloyl glycine help manage oily shine, while glycerin and panthenol provide deep hydration and support a strong skin barrier. These ingredients work together safely without causing irritation, keeping your skin feeling soft and balanced.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Thermal Water do for combination skin?

Thermal water helps hydrate dry areas and calm redness on combination skin, making it feel more comfortable. It is unlikely to clog pores and can be used throughout the day whenever skin needs a quick refresh.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/), [Journal of the European Academy of Dermatology and Venereology, 2020](https://pubmed.ncbi.nlm.nih.gov/32870553/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this cream go in a skincare routine for combination skin?

This moisturizer goes toward the end of your routine, right before sunscreen in the morning and as the final step in the evening. Using it regularly helps control oily shine while keeping your skin hydrated and balanced.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying it either before or after retinol to help keep your skin calm and hydrated. Using a barrier-supporting moisturizer alongside retinoids is safe and helps reduce dryness and irritation while you treat your skin.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily as part of your morning and evening routine. Regular daily application helps improve skin moisture and supports barrier resilience without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to clog pores or cause breakouts for combination skin, as its safe formula avoids harsh ingredients that trigger irritation. It helps keep skin balanced by providing comfortable hydration without heavy oils.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can I use this cream around the eyes or on my body?

This cream is generally safe to use on the thin skin around the eyes and on the body, as its gentle ingredients help keep skin hydrated and calm without irritation. Studies show that panthenol-containing moisturizers significantly improve skin moisture and barrier strength.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum).

## Alternatives for combination skin

- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/ca/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin) — Superior fit — CA$95.99 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/ca/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — CA$16.20 at Amazon
- [ANUA Heartleaf 70% Soothing Cream](https://lovi.care/skincare/ca/p/anua/heartleaf-70-soothing-cream/for/combination-skin) — High fit — CA$40.53 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/ca/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — CA$20.96 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Squalane, Dimethicone, Panthenol, Zea Mays Corn Starch, Niacinamide, Ammonium Polyacryloyldimethyl Taurate, Myristyl Myristate, Bixa Orellana Seed Extract, Stearic Acid, Potassium Cetyl Phosphate, Glyceryl Stearate Se, Sodium Hydroxide, Myristic Acid, 2-Oleamido-1,3-Octadecanediol, Palmitic Acid, Hydroxyacetophenone, Capryloyl Glycine, Caprylyl Glycol, Vitreoscilla Ferment, Citric Acid, Maltodextrin, Xanthan Gum, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin
- France: https://lovi.care/skincare/fr/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/la-roche-posay/effaclar-h-iso-biome-moisturiser/for/combination-skin