La Mer The Treatment Lotion for skin with dark spots

How to apply

Questions and answers

What the research says

• Topical myristyl nicotinate increased skin cell NAD, stratum corneum thickness, epidermal thickness, epidermal renewal, minimal erythemal dose, and barrier resistance while reducing transepidermal water loss in subjects with photodamaged skin compared to placebo.

  Experimental Dermatology, 2007

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Peptide fractions extracted from spent yeast waste streams are non-cytotoxic up to 500 µg/mL in HaCat and HDFa cells and positively modulate the production of skin metabolites including collagen, hyaluronic acid, fibronectin, and elastin.

  International Journal of Molecular Sciences, 2023

• A hydrogen water mask pack increased skin density by 18.41% compared to 9.93% for a commercial sample in participants after 4 weeks.

  International Journal of Molecular Sciences, 2020

• Topical application of magnetized saline water serum improved skin hydration, reduced transepidermal water loss, sebum content, melanin index, and erythema index, and activated autophagy by increasing Beclin-1 and decreasing mTOR in females wanting to enhance facial and neck skin appearance.

  Cureus, 2023

• Reconstruction of human skin equivalents under reduced relative humidity of 40% increased pyrrolidone carboxylic acid levels to match native tissue, but stratum corneum hydration levels remained lower unless water was topically applied.

  The Journal of Investigative Dermatology, 2008

• Treatment with lipid algae extract reduced the level of oxidized proteins in human keratinocytes and stratum corneum skin cells.

  Annals of the New York Academy of Sciences, 2004

• Topical astaxanthin-loaded algae extract hydrogel and lipogel formulations exhibited the highest antioxidant activity and successful in vitro release, suggesting their potential as anti-aging formulations.

  Journal of Cosmetic Dermatology, 2019

• Antarctic marine algae extracts increased cell viability, protected against inflammation, and enhanced the barrier integrity of human intestinal and keratinocyte cell lines damaged by lipopolysaccharide or ultraviolet radiation.

  Marine Drugs, 2022

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

  Annals of Dermatology, 2019

• Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.

  American Journal of Clinical Dermatology, 2013

• Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.

  Journal of Cosmetic Dermatology, 2017

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

Ingredients

Declustered Water, Water, Eau De-Structuree, Algae Extract, Glycerin, Methyl Gluceth-20, Bis-Peg-18 Methyl Ether Dimethyl Silane, Yeast Extract, Yeast, Extrait De Levure, Sucrose, Glycereth-26, Sesamum Indicum Seed Oil, Medicago Sativa Seed Powder, Helianthus Annuus Seedcake Sunflower Seedcake, Prunus Amygdalus Dulcis Seed Meal Seed, Eucalyptus Globulus Oil Leaf Eucalyptus Oil Leaf, Sodium Gluconate, Copper Gluconate, Calcium Gluconate, Magnesium Gluconate, Zinc Gluconate, Tocopheryl Succinate, Niacin, Citrus Aurantifolia Peel Extract, Glycine Soja Seed Extract Soybean Seed Extract, Laminaria Digitata Extract, Palmaria Palmata Extract, Codium Tomentosum Extract, Sea Salt, Sel Marin, Plankton Extract, Caffeine, Polyquaternium-51, Lecithin, Butylene Glycol, Dipotassium Glycyrrhizate, Glycine Soja Protein Soybean Protein, Tourmaline, Acetyl Hexapeptide-8, Glycosaminoglycans, Peg-8, Sodium Hyaluronate, Alcaligenes Polysaccharides, Sodium Pca, Urea, Ppg-5-Ceteth-20, Jojoba Peg-120 Esters Wax, Polysorbate 20, Hexylene Glycol, Pentylene Glycol, Potassium Sorbate, Trehalose, Caprylyl Glycol, Hydroxypropyl Cyclodextrin, Parfum, Disodium Edta, Limonene, Geraniol, Linalool, Hydroxycitronellal, Citronellol, Phenoxyethanol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.