# La Mer The Regenerating Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/la-mer/the-regenerating-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [La Mer](https://lovi.care/skincare/ca/brands/la-mer)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate treatment for your combination skin due to ingredients like yeast faex extract and saccharomyces lysate extract, which aid in skin regeneration and smoothing texture.
- While the algae extract and other components provide hydration and support your skin barrier function without being overly heavy, the formulation lacks targeted ingredients for your oily shine.
- The product is safe for your combination skin with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/la-mer/the-regenerating-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/la-mer/the-regenerating-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/la-mer/the-regenerating-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/la-mer/the-regenerating-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/la-mer/the-regenerating-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/la-mer/the-regenerating-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/la-mer/the-regenerating-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/la-mer/the-regenerating-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/la-mer/the-regenerating-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Miracle Broth, Acetyl Hexapeptide-8, Niacinamide, Algae Extract, Glycerin

## What the research says

- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Treatment with lipid algae extract reduced the level of oxidized proteins in human keratinocytes and stratum corneum skin cells. ([Annals of the New York Academy of Sciences, 2004](https://pubmed.ncbi.nlm.nih.gov/15247018/))
- Topical astaxanthin-loaded algae extract hydrogel and lipogel formulations exhibited the highest antioxidant activity and successful in vitro release, suggesting their potential as anti-aging formulations. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29745467/))
- Antarctic marine algae extracts increased cell viability, protected against inflammation, and enhanced the barrier integrity of human intestinal and keratinocyte cell lines damaged by lipopolysaccharide or ultraviolet radiation. ([Marine Drugs, 2022](https://pubmed.ncbi.nlm.nih.gov/36135751/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Users with dry, mature, or sensitive skin frequently praise this serum for its immediate soothing and plumping effects, often noting a visible improvement in skin texture and radiance. Many experience hydration and a reduction in fine lines, though a significant portion of reviewers feel the anti-aging results do not justify the extremely high price point compared to other market alternatives.

- Liked: Deeply Hydrating (mostly mentioned)
- Disliked: Extremely High Price (mostly mentioned)
- Liked: Luxurious Feel (often mentioned)
- Liked: Smooths Skin Texture (often mentioned)
- Liked: Soothing & Calming (sometimes noted)
- Disliked: Poor Pump Design (sometimes noted)
- Disliked: Caused Breakouts/Irritation (rarely noted)
- Disliked: Strong Fragrance (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does La Mer The Regenerating Serum work for combination skin?

La Mer The Regenerating Serum works moderately well for combination skin, providing smooth texture and balanced hydration without feeling overly heavy. However, this skin type needs a treatment with ingredients like niacinamide, zinc PCA, or propolis to help regulate oily shine and maintain a balanced glow.

### Which ingredients make this serum a good fit for combination skin?

This serum fits combination skin with yeast faex extract and saccharomyces lysate extract to smooth texture, alongside algae extract and glycerin for lightweight hydration. To work best for this skin type, a product also needs ingredients like niacinamide and zinc PCA to manage oily shine.

### What does Miracle Broth do for combination skin?

Miracle Broth is an average fit for combination skin because it lacks the lightweight hydration and oil-balancing ingredients this skin type needs. A product for combination skin needs to provide gentle moisture for dry areas without making oily zones greasy.

### What does Argireline do for combination skin?

Argireline helps smooth out lines and keeps combination skin feeling soft when applied twice daily. This ingredient may reduce wrinkle depth and improve overall skin texture, though its absorption through the skin is quite low.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Where does this serum go in a skincare routine for combination skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, to keep things simple and safe around sun exposure. Combination skin requires products of this type that provide lightweight hydration and smoothing ingredients while also helping control excess oil and shine.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to let it absorb, followed by your retinol. This product is unlikely to cause irritation on your combination skin since it lacks harsh ingredients, though a treatment for this skin type also needs ingredients that control oily shine.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. This helps keep things simple and gives you extra safety around sun exposure, though some treatments may also be used in the morning or twice a day.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for combination skin, as it has a safe profile with no harsh or prohibited ingredients. However, combination skin dealing with oily shine needs lightweight products with targeted balancing ingredients rather than this formula.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, linalool, limonene, citronellol, and geraniol).

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/combination-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/combination-skin) — Average fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Sephora: CA$585.00 (https://www.sephora.com/ca/en/product/the-regenerating-serum-P450290?skuId=2284164)
Prices checked 10 Oct 2026.

## Ingredients

Water, Algae Extract, Dimethicone, Hdi Trimethylol Hexyllactone Crosspolymer, Hydrogenated Polyisobutene, Caprylic Capric Myristic Stearic Triglyceride, Polysilicone-11, Peg-8 Dimethicone, Peg-10 Dimethicone, Yeast Faex Extrait De Levure Extract, Citrus Aurantifolia Peel Extract, Sigesbeckia Orientalis Extract, Polygonum Cuspidatum Root Extract, Saccharomyces Lysate Extract, Sesamum Indicum Seed Oil, Eucalyptus Globulus Oil Leaf Eucalyptus Oil Leaf, Sesamum Indicum Seed Powder, Medicago Sativa Seed Powder, Helianthus Annuus Seedcake Sunflower Seedcake, Prunus Amygdalus Dulcis Seed Meal Seed, Sodium Gluconate, Copper Gluconate, Calcium Gluconate, Magnesium Gluconate, Zinc Gluconate, Tocopheryl Succinate, Niacin, Vitis Vinifera Seed Extract Grape Seed Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Punica Granatum Fruit Juice, Bupleurum Falcatum Root Extract, Citrus Reticulata Peel Extract Tangerine Peel Extract, Narcissus Tazetta Bulb Extract, Mimosa Tenuiflora Bark Extract, Betula Alba Bark Extract, Chlorella Vulgaris Extract, Humulus Lupulus Extract, Laureth-4, Corallina Officinalis Extract, Glycine Soja Seed Extract Soybean Seed Extract, Micrococcus Lysate, Whey Lactis Proteine Du Petit-Lait Protein, Tartaric Acid, Glycerin, Hydrolyzed Wheat Protein, Laureth-23, Butylene Glycol, Ammonium Acryloyldimethyltaurate Beheneth-25 Methacrylate Crosspolymer, Sucrose, Coenzyme A, Acetyl Glucosamine, Caffeine, Dipalmitoyl Hydroxyproline, Linoleic Acid, Tetraacetylphytosphingosine, Alcaligenes Polysaccharides, Bifida Lysate Ferment, Pentylene Glycol, Dipotassium Glycyrrhizate, Palmitoyl Oligopeptide, Peg-8, Sorbitol, Tocopheryl Acetate, Eryngium Maritimum Extract, Sodium Hydroxide, Hydrogenated Lecithin, Hydroxypropyl Cyclodextrin, Nordihydroguaiaretic Acid, Cyclodextrin, Maltodextrin, Acetyl Hexapeptide-8, Glyceryl Polymethacrylate, Glycosaminoglycans, Gold, Tourmaline, Linolenic Acid, Silica, Ethylbisiminomethylguaiacol Manganese Chloride, Disodium Edta, Potassium Sorbate, Phenoxyethanol, Parfum, Hydroxycitronellal, Linalool, Limonene, Citronellol, Geraniol, Green 5 Ci 61570
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-mer/the-regenerating-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-mer/the-regenerating-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/la-mer/the-regenerating-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/la-mer/the-regenerating-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/la-mer/the-regenerating-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/la-mer/the-regenerating-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/la-mer/the-regenerating-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/la-mer/the-regenerating-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/la-mer/the-regenerating-serum/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/la-mer/the-regenerating-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/la-mer/the-regenerating-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/la-mer/the-regenerating-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/la-mer/the-regenerating-serum/for/combination-skin