# Isntree C-Niacin Toning Ampoule for acne-prone skin

**Lovi Fit: Superior fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: Superior · Safety: High.

Page: https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Isntree](https://lovi.care/skincare/ca/brands/isntree)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for acne-prone skin.

## Why this fit

- Excellent suitability for your combination skin as 3-O-Ethyl Ascorbic Acid and Niacinamide effectively regulate oil production and brighten your skin tone, addressing your concerns with acne and breakouts.
- The inclusion of Aloe Barbadensis Leaf Extract and Allantoin provides soothing benefits, further enhancing comfort and suitability for your skin.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of calming components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin): Superior (this page)
- [Skin with dark spots](https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/oily-acne-prone-skin): Superior

## Key ingredients

Niacinamide, 3-O-Ethyl Ascorbic Acid Ascorbic Acid, Hippophae Rhamnoides Fruit Extract, Sodium Hyaluronate, Aloe Barbadensis Leaf Extract

## What the research says

- A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of a sea buckthorn fruit extract formulation significantly reduced skin sebum secretion in 10 healthy human volunteers compared to the control base over an 8-week period. ([Journal of Pharmacy & Bioallied Sciences, 2010](https://pubmed.ncbi.nlm.nih.gov/21814424/))
- Topical emulsions containing Hippophae rhamnoides and Cassia fistula plant extracts significantly reduced skin sebum contents compared to placebo in patients with grade I and grade II acne vulgaris. ([Postepy Dermatologii I Alergologii, 2014](https://pubmed.ncbi.nlm.nih.gov/25254008/))
- Topical application of a 5% Hippophae rhamnoides oil-in-water emulsion significantly improved skin hydration (p=0.0003) and transepidermal water loss (p=0.0087) compared to a placebo base formulation in 13 healthy male subjects over 84 days. ([Pakistan Journal of Pharmaceutical Sciences, 2014](https://pubmed.ncbi.nlm.nih.gov/25362595/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))
- Formulations containing 0.10%, 0.25%, and 0.50% freeze-dried Aloe vera extract increased stratum corneum water content compared with the vehicle in 20 female subjects, while transepidermal water loss was not modified. ([Skin Research and Technology, 2006](https://pubmed.ncbi.nlm.nih.gov/17026654/))

## What reviewers say

This ampoule is frequently praised for its lightweight, fast-absorbing texture and its ability to gently brighten the skin, providing a natural glow. It is well-tolerated by sensitive and acne-prone skin types. Some users report that results are subtle and require consistent long-term use, with a few experiencing minor breakouts or noting the watery consistency can be difficult to handle.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Brightens and glows (often mentioned)
- Liked: Gentle on sensitive skin (often mentioned)
- Liked: Hydrating (sometimes noted)
- Disliked: Slow or minimal results (sometimes noted)
- Disliked: Minor breakouts (rarely noted)
- Disliked: Runny consistency (rarely noted)
- Disliked: Slight tackiness (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Isntree C-Niacin Toning Ampoule one of the best fits for acne-prone skin?

This is one of the best fits for acne-prone skin because Niacinamide and 3-O-Ethyl Ascorbic Acid effectively regulate oil production and brighten skin tone, which helps address breakouts. Additionally, ingredients like Aloe Barbadensis Leaf Extract and Allantoin provide soothing benefits that keep skin calm and comfortable.
Sources: [Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/), [Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit because Niacinamide and 3-O-Ethyl Ascorbic Acid help control excess oil and brighten dark spots from breakouts. Additionally, Aloe Barbadensis Leaf Extract and Allantoin soothe your skin and keep it calm.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/), [Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### What does 3-O-Ethyl Ascorbic Acid do for acne-prone skin?

3-O-Ethyl Ascorbic Acid is unlikely to aggravate acne-prone skin and may help calm breakouts while brightening dark marks left by blemishes. Vitamin C derivatives support clearer skin by helping to reduce inflammation and balancing skin tone safely.
Sources: [Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/36986679/), [Journal of Cosmetic Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/23174055/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment serum goes in the evening routine after your cleansing toner and before your moisturizer. It is very well suited for acne-prone skin because niacinamide and vitamin C help regulate oil production and brighten your skin tone.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help control oil and brighten your skin, followed by your retinol. The product is unlikely to irritate your skin when combined, as it is free of harsh ingredients and includes calming components.

### How often should I use this serum?

This treatment is used in the evening routine, starting once a week, and people who tolerate it well and see good results can carefully use it more often. It helps regulate oil production and brighten your skin tone while keeping breakouts under control.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit for acne-prone skin because niacinamide and vitamin C help control oil production while soothing ingredients calm redness and breakouts. It is unlikely to cause irritation or breakouts thanks to its gentle formula, though a few reviewers have reported minor breakouts.
Sources: [Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/), [Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/acne-prone-skin) — High fit — CA$27.99 at Amazon
- [ANUA PEACH 70% NIACINAMIDE SERUM](https://lovi.care/skincare/ca/p/anua/peach-70-niacinamide-serum/for/acne-prone-skin) — High fit — CA$33.50 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/ca/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — CA$22.95 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — CA$41.00 at Amazon
- Moisturizer: [CeraVe CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/ca/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — CA$20.96 at Amazon

## Where to buy

- Amazon.ca: CA$25.98 (https://www.amazon.ca/dp/B07VYVRXJ6?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Hippophae Rhamnoides Fruit Extract, Butylene Glycol, Pentylene Glycol, Glycerin, Betaine, Water, Niacinamide, Propanediol, Aloe Barbadensis Leaf Extract, Melia Azadirachta Flower Extract, Melia Azadirachta Leaf Extract, Pumpkin Fruit Extract, Physalis Alkekengi Fruit Extract, Sodium Hyaluronate, Dipotassium Glycyrrhizate, Ocimum Sanctum Leaf Extract, Beta-Glucan, Curcuma Longa Root Extract, Corallina Officinalis Extract, Brassica Oleracea Italica Extract, Coccinia Indica Fruit Extract, Moringa Oleifera Seed Oil, Boswellia Serrata Extract Resin, Bioflavonoids, Panthenol, Allantoin, Sodium Polyacrylate, Tocopherol, Polysorbate 80, 1,2-Hexanediol, Ethyl Hexanediol, Ammonium Acryloyldimethyltaurate Vp Copolymer, 3-O-Ethyl Ascorbic Acid, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Usnea Barbata Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin
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- Italy: https://lovi.care/skincare/it/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/isntree/c-niacin-toning-ampoule/for/acne-prone-skin