# iS Clinical Super Serum Advance+ for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [iS Clinical](https://lovi.care/skincare/ca/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin brightening and smoothing for your combination skin, as Ascorbic Acid and Arbutin work synergistically to treat acne, blemishes, and breakouts while Sodium Hyaluronate provides essential hydration.
- The formula is highly compatible with your skin type, with Urea and Calcium Pantothenate further supporting skin health and texture.
- This product is safe for your acne-prone skin, containing no harsh ingredients and including soothing components like Ascorbic Acid and Urea.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin): High

## Key ingredients

Ascorbic Acid, Sodium Hyaluronate, Arbutin, Tripeptide-1, Madecassic Acid

## What the research says

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- Polyvinyl pyrrolidone-K90/Eudragit RL100 dissolving microneedle patches loaded with alpha-arbutin and resveratrol enhanced intradermal delivery by approximately 2.6 times compared to cream and slightly decreased the melanin index in human participants without causing skin irritation. ([Biomaterials Science, 2023](https://pubmed.ncbi.nlm.nih.gov/37183632/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))

## What reviewers say

This serum is highly regarded for its ability to brighten skin and reduce the appearance of scars and stretch marks. It is often described as a lightweight, fast-absorbing treatment suitable for acne-prone and aging skin, although its high price is a frequent concern among users.

- Liked: Brightens skin tone (mostly mentioned)
- Liked: Anti-aging effects (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Reduces scars/marks (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Non-irritating (sometimes noted)
- Disliked: Watery consistency (sometimes noted)
- Disliked: Application sensation (rarely noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Packaging/Value (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes iS Clinical Super Serum Advance+ a great fit for acne-prone skin?

This product is a great fit for your acne-prone skin because ascorbic acid and arbutin work together to treat breakouts and smooth your skin while sodium hyaluronate gives it essential hydration. It also has urea and calcium pantothenate to support overall skin health and texture without any harsh ingredients.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Which ingredients make this serum a good fit for acne-prone skin?

Ascorbic acid and arbutin make this serum a great fit by helping to treat breakouts, while sodium hyaluronate adds essential hydration without clogging pores. The formula also includes urea and madecassic acid, which safely soothe and support acne-prone skin.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What does Vitamin C do for acne-prone skin?

Vitamin C helps brighten skin, smooth out uneven tones, and fade dark spots left behind by breakouts. It is also packed with antioxidants that may help protect acne-prone skin from everyday environmental stress.
Sources: [Journal of Drugs in Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39231081/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Using it at night helps keep things simple and protects your skin from extra sensitivity around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment first and then following with your retinol product, or by using this serum in your morning routine and retinol at night. This approach helps you treat breakouts while keeping your skin calm and smooth.
Sources: [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### How often should I use this serum?

This treatment is great for your acne-prone skin and fits into your evening routine. You can safely apply it every evening to help smooth your skin and clear blemishes.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit for your acne-prone skin because it contains soothing ingredients like Ascorbic Acid and Urea without any harsh components. It is safe to use and is unlikely to cause breakouts or clog pores.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/acne-prone-skin) — High fit — CA$27.99 at Amazon
- [ANUA PEACH 70% NIACINAMIDE SERUM](https://lovi.care/skincare/ca/p/anua/peach-70-niacinamide-serum/for/acne-prone-skin) — High fit — CA$33.50 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/ca/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — CA$22.95 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — CA$41.00 at Amazon
- Moisturizer: [CeraVe CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/ca/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — CA$20.96 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Ascorbic Acid, Sodium Hyaluronate, Pentylene Glycol, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Calcium Pantothenate, Zinc Sulfate, Urea, Glucose, Guanidine Hcl, Tripeptide-1, Glycerin, Phenoxyethanol, Asiaticoside, Asiatic Acid, Madecassic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/super-serum-advance/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/super-serum-advance/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/super-serum-advance/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/super-serum-advance/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/super-serum-advance/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/super-serum-advance/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/super-serum-advance/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/super-serum-advance/for/acne-prone-skin