# HYDRINITY Renewing HA Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/hydrinity/renewing-ha-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [HYDRINITY](https://lovi.care/skincare/ca/brands/hydrinity)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Highly suitable for your normal skin, this serum effectively addresses wrinkles and fine lines with Trifluoroacetyl Tripeptide-2 and Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 to support collagen production and elasticity.
- Its excellent moisturizing properties are provided by Hyaluronic Acid and Glycerin, which hydrate and plump the skin, while Bisabolol and Algae Extract offer soothing benefits.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of calming components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/hydrinity/renewing-ha-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/hydrinity/renewing-ha-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/hydrinity/renewing-ha-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/hydrinity/renewing-ha-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/hydrinity/renewing-ha-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/hydrinity/renewing-ha-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/hydrinity/renewing-ha-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/hydrinity/renewing-ha-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/hydrinity/renewing-ha-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Hyaluronic Acid, Glycerin, Squalane, Trifluoroacetyl Tripeptide-2, Zingiber Officinale Root Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- A 1-year clinical study on human facial skin demonstrated that Zingiber officinale (L.) Rose extract inhibits the UV-induced decrease in skin elasticity and prevents or improves wrinkle formation around the eye. ([Archives of Dermatological Research, 2008](https://pubmed.ncbi.nlm.nih.gov/17968573/))
- Ginger extract transethosomal hydrogel improved skin permeability, sustained drug release, and exhibited significant inhibition of edema swelling along with reduced reactive oxygen species and prostaglandin E2 compared to free ginger extract hydrogel and ketoprofen gel in a rat-paw edema model. ([International Journal of Nanomedicine, 2023](https://pubmed.ncbi.nlm.nih.gov/36945254/))
- Topical delivery of ginger extract-loaded nanoemulsions significantly reduced arthritic symptoms, paw edema inhibition by 27.7%, and inflammatory cytokines in RA-induced rats compared to the negative control. ([Journal of Pharmaceutical Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/36773928/))

## What reviewers say

This serum is frequently praised for its lightweight, non-greasy formula that effectively plumps and firms the skin, providing deep hydration. It is particularly favored by those seeking anti-aging benefits and improved skin resilience, with many users noting visible improvements in texture and radiance within a few weeks of consistent use. Some users find the scent opinions to be mixed, and the price point is considered premium by some, with results building progressively over time.

- Liked: Deep hydration (mostly mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Lightweight formula (often mentioned)
- Liked: Anti-aging results (sometimes noted)
- Liked: Sensitive skin friendly (sometimes noted)
- Disliked: Premium price point (sometimes noted)
- Disliked: Requires consistency (sometimes noted)
- Disliked: Mixed scent opinions (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes HYDRINITY Renewing HA Serum a great fit for mature skin?

HYDRINITY Renewing HA Serum is a great fit for mature skin because it targets wrinkles and fine lines using peptides that support collagen and elasticity. It also deeply hydrates and plumps the skin with hyaluronic acid and glycerin, while soothing ingredients help keep irritation low.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this serum a good fit for mature skin?

Trifluoroacetyl Tripeptide-2 and Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 make this serum a good fit for mature skin by supporting collagen production and elasticity. Additionally, hyaluronic acid and glycerin help hydrate and plump the skin to effectively address wrinkles and fine lines.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, though some serums may also be used in the morning or twice a day. Putting treatments in the evening provides simplicity and extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this hydrating serum with retinol to help keep your mature skin soft and comfortable while reducing the look of fine lines. Apply the serum after your retinol absorbs, or use it beforehand to help your skin tolerate the retinol better.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this serum in the evening as part of your routine, and some people also use it in the morning or twice a day. Daily application helps improve skin moisture, firmness, and fine lines while keeping your skin calm and comfortable.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin. It features an exceptionally safe formula without harsh ingredients, helping to keep your skin calm and clear.

### Can I use this serum around the eyes or on my body?

Yes, you can apply this moisturizing treatment around the eyes and on the body because its gentle formula has an excellent safety profile without harsh ingredients. Hyaluronic acid and glycerin help hydrate and plump thin areas, while peptides and botanical extracts support elasticity and smooth out fine lines.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/ca/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin) — High fit — CA$37.99 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/ca/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/mature-skin) — Average fit — CA$21.81 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ca/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — CA$31.98 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — CA$27.34 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Hyaluronic Acid, Glycerin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Dimethicone, Butylene Glycol, Trifluoroacetyl Tripeptide-2, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76, Bisabolol, Algae Extract, Zingiber Officinale Root Extract, Terminalia Ferdinandiana Fruit Extract, Squalane, Pullulan, Pentylene Glycol, Dextran, Sodium Stearoyl Glutamate, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Citric Acid, Chlorphenesin, Caprylyl Glycol, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/hydrinity/renewing-ha-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/hydrinity/renewing-ha-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/hydrinity/renewing-ha-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/hydrinity/renewing-ha-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/hydrinity/renewing-ha-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/hydrinity/renewing-ha-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/hydrinity/renewing-ha-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/hydrinity/renewing-ha-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/hydrinity/renewing-ha-serum/for/mature-skin (this page)
- Australia: https://lovi.care/skincare/au/p/hydrinity/renewing-ha-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/hydrinity/renewing-ha-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/hydrinity/renewing-ha-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/hydrinity/renewing-ha-serum/for/mature-skin