# DRMTLGY Peptide Night Cream for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/ca/p/drmtlgy/peptide-night-cream/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [DRMTLGY](https://lovi.care/skincare/ca/brands/drmtlgy)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as ceramides and peptides enhance barrier resilience and glycerin provides humectant action, but it lacks sufficient ingredients for optimal oil control on your oily shine.
- Allantoin and shea butter offer soothing benefits, contributing to general skincare, but the primary goal of managing oily shine is not directly addressed.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/drmtlgy/peptide-night-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/drmtlgy/peptide-night-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ca/p/drmtlgy/peptide-night-cream/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/drmtlgy/peptide-night-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/drmtlgy/peptide-night-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/drmtlgy/peptide-night-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/drmtlgy/peptide-night-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/drmtlgy/peptide-night-cream/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/drmtlgy/peptide-night-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Peptides, Ceramides, Shea Butter, Tocopherol Vitamin E, Allantoin

## What the research says

- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Prophylactic application of a topical scar gel containing Allium cepae extract, allantoin, and heparin significantly improves patient-assessed scar color, stiffness, and irregularity compared to no treatment in women following a cesarean section. ([Journal of Drugs in Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24509969/))

## What reviewers say

Based on a very large amount of data, this fragrance-free night cream is highly regarded for its rich yet non-greasy texture, providing deep hydration and plumping effects. Users frequently report improvements in skin texture, reduced fine lines, and a strengthened moisture barrier, making it suitable for sensitive and aging skin types. Some users find the jar packaging unhygienic, and a few with very dry skin may require additional moisture, while others note it can be too heavy for daytime use. Availability can also be a concern due to frequent sell-outs.

- Liked: Deep hydration (mostly mentioned)
- Liked: Gentle formula (often mentioned)
- Liked: Non-greasy texture (often mentioned)
- Liked: Anti-aging benefits (sometimes noted)
- Liked: Value for money (sometimes noted)
- Disliked: Jar packaging (sometimes noted)
- Disliked: Availability issues (rarely noted)
- Disliked: Not rich enough (rarely noted)
- Disliked: Too heavy for day (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does DRMTLGY Peptide Night Cream work for combination skin?

This cream works moderately well for combination skin because ceramides and peptides strengthen your skin barrier while glycerin keeps it soft and hydrated, though it lacks enough ingredients to control oily shine. To work best for this skin type, a moisturizing treatment needs effective oil-control ingredients alongside reliable hydrators to balance both dry and oily areas.

### Which ingredients make this cream a good fit for combination skin?

Ceramides and peptides in this cream enhance skin barrier resilience, while glycerin helps keep skin hydrated. However, a product for combination skin also needs targeted ingredients for oil control to manage oily shine.

### What do Peptides do for combination skin?

Peptides help combination skin by keeping it smooth, supporting firmness, and boosting hydration. They also help reduce the appearance of lines and encourage skin repair, though absorption depends on the formula.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40565185/), [Food & Function, 2019](https://pubmed.ncbi.nlm.nih.gov/31497829/)

### What do Ceramides do for combination skin?

Ceramides help balance combination skin by supporting the skin barrier to keep dry areas hydrated without feeling heavy on oily zones. This type of skin needs lightweight hydrators and barrier-supporting ingredients like ceramides and cholesterol to maintain a smooth and calm feel across both dry and oily areas.
Sources: [American Journal of Clinical Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12553851/), [Scientific Reports, 2022](https://pubmed.ncbi.nlm.nih.gov/35340018/)

### Where does this cream go in a skincare routine for combination skin?

This cream goes in the evening routine as the final step after your treatment, or in the morning routine if your skin feels dry. To work best for combination skin, a product of this type needs lightweight hydrators and oil-control ingredients that balance shine while keeping dry zones soft.

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the retinol first in your evening routine, letting it absorb, and then smoothing on this cream to help reduce dryness. A moisturizer with barrier-strengthening ceramides and peptides is useful alongside retinol, though combination skin also needs targeted oil control ingredients to manage shine.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

This cream works for combination skin, though other products fit it better because it lacks ingredients to manage oily shine. To get the best results for your skin, a product of this type needs added oil-controlling ingredients to balance moisture while keeping shine in check.

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to cause purging, but it may feel a bit heavy and lead to breakouts in your oilier zones because it lacks ingredients for oil control. Combination skin needs lightweight hydrators and balancing ingredients that clear excess oil without clogging pores.

### Can I use this cream around the eyes or on my body?

This cream works fine on the body, but it is not specifically tested or formulated for the very thin skin around the eyes.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/ca/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin) — Superior fit — CA$95.99 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/ca/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — CA$16.20 at Amazon
- [ANUA Heartleaf 70% Soothing Cream](https://lovi.care/skincare/ca/p/anua/heartleaf-70-soothing-cream/for/combination-skin) — High fit — CA$40.53 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/ca/p/cerave/am-facial-moisturizing-lotion-spf-30/for/combination-skin) — Superior fit — CA$20.96 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii Butter Shea Butter, Caprylic Capric Triglyceride, Cetyl Alcohol, Dimethicone, Peg-100 Stearate, Ceramide Eop, Ceramide Ap, Palmitoyl Tetrapeptide-7, Ceramide Np, Palmitoyl Tripeptide-1, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-5, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Allantoin, Phytosphingosine, Cholesterol, Tridecane, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Butylene Glycol, Glycol Distearate, Ethylhexylglycerin, Potassium Cetyl Phosphate, Carbomer, Sodium Hydroxide, Disodium Edta, Sodium Lauroyl Lactylate, Polysorbate 20, Dextran, Xanthan Gum, Phenoxyethanol, Magnesium Chloride
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/drmtlgy/peptide-night-cream/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/drmtlgy/peptide-night-cream/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/drmtlgy/peptide-night-cream/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/drmtlgy/peptide-night-cream/for/combination-skin
- France: https://lovi.care/skincare/fr/p/drmtlgy/peptide-night-cream/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/drmtlgy/peptide-night-cream/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/drmtlgy/peptide-night-cream/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/drmtlgy/peptide-night-cream/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/drmtlgy/peptide-night-cream/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/drmtlgy/peptide-night-cream/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/drmtlgy/peptide-night-cream/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/drmtlgy/peptide-night-cream/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/drmtlgy/peptide-night-cream/for/combination-skin