Dermalogica PowerBright Dark Spot Serum for dry sensitive skin

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Questions and answers

What the research says

• A formulation combining 4-hexylresorcinol and niacinamide significantly improved hyperpigmentation, skin tone, fine lines, wrinkles, and firmness compared to niacinamide alone in Chinese subjects without adverse events.

  International Journal of Cosmetic Science, 2022

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical 1% hexylresorcinol is equivalent to 2% hydroquinone in significantly reducing the appearance of facial and hand pigmentation in healthy female participants over 12 weeks, with both treatments showing no adverse effects.

  Archives of Dermatological Research, 2023

• Self-assembled cubic liquid crystalline nanoparticles loaded with paeonol reduced skin irritation compared to commercial ointment, serving as a promising transdermal delivery system.

  Medical Science Monitor, 2015

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation.

  International Journal of Cosmetic Science, 2024

• A topical cream containing retinol 0.5% in combination with niacinamide, resveratrol, and hexylresorcinol improved all efficacy endpoints including fine lines, radiance, smoothness, hyperpigmentation, and wrinkles in 25 subjects with photodamaged and aging skin over 10 weeks.

  Journal of Drugs in Dermatology, 2016

• A topical formulation containing hexylresorcinol, silymarin, 20% vitamin C, and 5% vitamin E prevented UVB-induced photodamage in skin explants and produced clinical improvements in brightening, evenness, lines, and global appearance in 42 female subjects over 12 weeks.

  Journal of Cosmetic Dermatology, 2020

• Lentinan reduced benzo(a)pyrene-induced oxidative stress, malondialdehyde levels, and inflammatory cytokine production while increasing antioxidant enzyme activities in human keratinocytes.

  Journal of Cosmetic Dermatology, 2020

• Shiitake mushroom ethanol extract exhibited moderate antioxidant capacity, 51.99% elastase inhibition, concentration-dependent collagenase suppression, and non-toxicity in human keratinocytes, supporting its safe incorporation into stable topical anti-aging skin-care formulations.

  Journal of Cosmetic Dermatology, 2026

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Partially purified paeoniflorin protected human keratinocytes and mouse skin from UV-induced DNA damage and reduced facial wrinkles in human volunteers.

  Journal of Cosmetic Science, 2006

• Paeonia suffruticosa callus extract downregulated inflammatory factors, alleviated DNA damage, and increased total collagen content in in vitro and in vivo evaluations.

  International Journal of Cosmetic Science, 2025

• Topical application of Paeonia lactiflora root extract and paeoniflorin significantly decreases melanin content by 23% to 30% in reconstructed pigmented human epidermis compared to vehicle control.

  International Journal of Cosmetic Science, 2016

Ingredients

Water, Ethylhexyl Isononanoate, Triolein, Niacinamide, C12-16 Alcohols, 1,2-Hexanediol, Coco-Caprylate Caprate, Lentinus Edodes Mycelium Extract, C18-36 Acid Triglyceride, Acrylates Copolymer, Butylene Glycol, Ectoin, Paeonia Suffruticosa Root Extract, Jojoba Esters, Hydroxyacetophenone, Hexylresorcinol, Phytosteryl Macadamiate, Sodium Hyaluronate Crosspolymer, Phytosterols, Sodium Levulinate, C12-18 Acid Triglyceride, Raspberry Ketone, Mimosa Tenuiflora Bark Extract, Vanilla Planifolia Fruit, Ilex Paraguariensis Leaf Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Prunus Amygdalus Dulcis Oil, Citrus Aurantium Dulcis Peel Oil, Bergamot Oil Fruit, Lemon Peel Oil, Grapefruit Peel Oil, Ricinus Communis Seed Oil Castor Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Cistus Ladaniferus Resin, Zingiber Officinale Oil Root, Lavandula Angustifolia Oil Lavender Oil, Ribes Nigrum Seed Oil, Jasminum Sambac Flower Extract Jasmine Flower Extract, Cucumis Sativus Seed Oil, Dipteryx Odorata Seed Extract, Styrax Benzoin Extract Resin, Viola Odorata Leaf Extract, Juniperus Virginiana Oil, Titanium Dioxide, Tocopherol, Ethylhexylglycerin, Xanthan Gum, Sclerotium Gum, Hydrogenated Lecithin, Lecithin, Palmitic Acid, Octyldecanol, Glycerin, Octyldodecyl Oleate, Squalene, Octyldodecyl Stearoyl Stearate, Tetrasodium Glutamate Diacetate, Caprylyl Glycol, Benzyl Glycol, Laureth-21, Pullulan, Silica, Alumina, Sodium Hydroxide, Sodium Glycolate, Sodium Dehydroacetate, Sodium Benzoate, Sodium Formate, Citral, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.