# Dear, Klairs Midnight Blue Youth Activating Drop for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Dear, Klairs](https://lovi.care/skincare/ca/brands/dear-klairs)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your oily skin as Sh-Oligopeptide-1 and Sh-Polypeptide-1 stimulate collagen and boost ECM synthesis, addressing your concerns about acne, blemishes, and breakouts with moderate effectiveness.
- Blueberry fruit extract and guaiazulene provide antioxidant and soothing benefits, complementing the primary ingredients for overall skin health.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Rh-Oligopeptide-1, Sh-Oligopeptide-1, Sh-Polypeptide-1, Blueberry Fruit Extract, Guaiazulene

## What the research says

- Bovine basic fibroblast growth factor combined with ultrapulsed fractional CO2 laser increased the overall response rate, reduced ECCA scores, scar base depth, skin pore value, texture value, transepidermal water loss, redness duration, scabbing duration, erythema duration, and adverse reactions, while increasing skin water and epidermal oil content in patients with acne scars compared to ultrapulsed fractional CO2 laser therapy alone. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37841061/))
- Bog blueberry anthocyanin-rich extract attenuated ultraviolet-B-induced toxicity, DNA damage, collagen degradation, and inflammatory cytokine release in human dermal fibroblasts by modulating NF-kappaB and MAPK signaling pathways. ([Molecular Nutrition & Food Research, 2009](https://pubmed.ncbi.nlm.nih.gov/19199288/))
- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))
- Topical application of PTD-EGF and FGF1 increased cell proliferation and collagen accumulation while protecting against UV-induced damage and improving wrinkle parameters in human skin. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/24305427/))
- Basic fibroblast growth factor-loaded human serum albumin nanoparticles enhanced the proliferation and migration of human dermal fibroblasts, down-regulated myofibroblast-related genes, and accelerated wound healing with enhanced angiogenesis in vivo compared to unstable native forms. ([Journal of Nanobiotechnology, 2023](https://pubmed.ncbi.nlm.nih.gov/37658367/))
- Topical application of basic fibroblast growth factor decreases elevated transepidermal water loss and increases Ki67 expression in keratinocytes following mechanical scratching in a mouse model. ([Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23108135/))
- Applying a topical product containing blueberry extract and Pro-xylane following micro-focused ultrasound significantly improved global aesthetic improvement, skin elasticity, and fine lines compared to standard moisturizer in 50 patients. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40635529/))
- Topical usage of blueberries may prevent skin damage from environmental stressors by inducing an active skin response against noxious effects. ([Antioxidants, 2023](https://pubmed.ncbi.nlm.nih.gov/37371992/))
- Pretreatment with blueberry extracts prevented ozone-induced ROS production, NLRP1-ASC scaffold formation, and CASP1 and IL-18 transcripts across 2D, 3D, and human skin explant models. ([Oxidative Medicine and Cellular Longevity, 2020](https://pubmed.ncbi.nlm.nih.gov/32855770/))

## What reviewers say

Based on a very large amount of data, this product is widely praised as a lightweight, watery anti-aging serum that absorbs instantly and is exceptionally gentle, making it a favorite for oily and sensitive skin types. Many users report smoother skin texture, reduced redness, and a plump feel. Some find the 20ml bottle too small for the price and note that its preventative anti-aging effects take time to become visible.

- Liked: Rapid absorption (mostly mentioned)
- Disliked: Small volume/price (mostly mentioned)
- Liked: Gentle formula (often mentioned)
- Liked: Soothing & calming (often mentioned)
- Liked: Improves texture (sometimes noted)
- Disliked: Slow visible results (sometimes noted)
- Disliked: Watery consistency (sometimes noted)
- Disliked: Not moisturizing (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes the Midnight Blue Youth Activating Drop a great fit for oily acne-prone skin?

This treatment is a great fit for your oily, acne-prone skin because its peptides help boost collagen and address blemishes, while blueberry extract and guaiazulene provide soothing benefits. It is also safe for your skin, with no risk of irritation from harsh ingredients.
Sources: [Molecular Nutrition & Food Research, 2009](https://pubmed.ncbi.nlm.nih.gov/19199288/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Sh-oligopeptide-1 and sh-polypeptide-1 make this serum a great fit by stimulating collagen to help manage breakouts and blemishes on oily skin. Blueberry fruit extract and guaiazulene further support skin health by providing antioxidant and calming benefits.
Sources: [Molecular Nutrition & Food Research, 2009](https://pubmed.ncbi.nlm.nih.gov/19199288/), [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37841061/)

### What does EGF do for oily acne-prone skin?

EGF helps calm redness and breakouts, and it may improve the look of acne scars on oily skin. It also supports the skin barrier while increasing skin water and oil balance.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37841061/), [International Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24962549/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after your cleansing toner and before your moisturizer. It is a great fit for your oily skin because specific peptides stimulate collagen to help address acne and breakouts, while blueberry fruit extract and guaiazulene provide soothing benefits with no risks of irritation.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment first and following with your retinol product. This approach helps calm your skin and address breakouts while minimizing the risk of irritation.

### How often should I use this serum?

This treatment is used in the evening as part of your routine. It is a great fit for your oily skin because it helps calm and soothe while addressing acne and breakouts without irritation.
Sources: [Molecular Nutrition & Food Research, 2009](https://pubmed.ncbi.nlm.nih.gov/19199288/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for your oily, acne-prone skin. It features soothing ingredients like guaiazulene and blueberry fruit extract that help calm your skin without adding heavy oils.
Sources: [Molecular Nutrition & Food Research, 2009](https://pubmed.ncbi.nlm.nih.gov/19199288/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/oily-acne-prone-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/oily-acne-prone-skin) — High fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Amazon.ca: CA$19.99 (https://www.amazon.ca/dp/B0GJZ9BV8R?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Butylene Glycol, Sh-Oligopeptide-1, Sh-Polypeptide-1, Blueberry Fruit Extract, Lecithin, Sorbitan Sesquioleate, 1,2-Hexanediol, Caprylyl Glycol, Peg-60 Hydrogenated Castor Oil, Glycerin, Chlorphenesin, Guaiazulene, Ethylhexylglycerin, Adenosine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/dear-klairs/midnight-blue-youth-activating-drop/for/oily-acne-prone-skin