# Clinique Smart Clinical Repair Wrinkle Correcting Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Clinique](https://lovi.care/skincare/ca/brands/clinique)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- This serum offers moderate wrinkle reduction for your combination skin, with peptides like acetyl hexapeptide-8 and hydroxypinacolone retinoate supporting texture smoothing. Glycerin and sodium hyaluronate provide essential hydration, which is beneficial for managing oily shine and combination skin.
- The formulation is highly suitable for your combination skin due to the humectant action of glycerin and sodium hyaluronate, complemented by the emollient properties of squalane.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of harsh ingredients and the presence of soothing agents like Glycyrrhetinic Acid and Algae Extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Cl1870 Laser Focus Complex, Retinoid, Hyaluronic Acid Concentrate, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A dermo-cosmetic formula containing 2% enoxolone significantly reduced erythema at 24 hours and pain at 30 minutes following non-ablative fractional laser treatment in 10 healthy subjects compared to a moisturizer control. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38622995/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## What reviewers say

Based on a very large amount of data, users consistently praise this serum for its lightweight, fragrance-free formula that effectively hydrates and smooths skin texture without causing irritation, making it suitable for sensitive skin. While many report visible improvements in fine lines, plumpness, and overall radiance, some users note that deep wrinkles require consistent, long-term use to show significant changes and that the high price point is a consideration.

- Liked: Smoother skin (mostly mentioned)
- Liked: Hydrating and plumping (often mentioned)
- Liked: Lightweight absorption (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Gentle formula (sometimes noted)
- Liked: Reduces fine lines (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Pump issues (rarely noted)
- Disliked: Sun sensitivity (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Clinique Smart Clinical Repair Wrinkle Correcting Serum work for combination skin?

This serum works moderately well for your combination skin, using peptides and retinoids to help smooth texture while glycerin and sodium hyaluronate provide essential hydration to manage oily shine. A product of this type needs effective ingredients like niacinamide, propolis, or zinc PCA to regulate oiliness, enhance radiance, and provide balanced hydration without any risk of irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this serum a good fit for combination skin?

Glycerin and sodium hyaluronate make this serum a good fit for your combination skin by providing essential hydration to manage oily shine, while peptides and retinoids support texture smoothing. A treatment of this type needs effective ingredients like niacinamide, propolis, or zinc PCA to enhance radiance and regulate oiliness without causing excess oiliness or dryness.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Cl1870 Laser Focus Complex do for combination skin?

Cl1870 Laser Focus Complex helps smooth fine lines and supports skin firmness by encouraging collagen production. For combination skin, a product of this type needs a balanced formula with ingredients that hydrate dry areas without clogging oily zones.
Sources: [Current Protein & Peptide Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34382523/)

### What does Retinoid do for combination skin?

Retinoid helps combination skin by smoothing texture, evening out tone, and keeping pores clear. This type of ingredient works best for combination skin when it also includes gentle hydrators like hyaluronic acid or niacinamide to balance dry areas while managing oil.
Sources: [Journal of Drugs in Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27391637/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051835/)

### Where does it go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and before moisturizing, for simplicity and extra safety around sun exposure. Combination skin generally benefits most from lightweight, balancing serums that control oily shine while delivering deep hydration.

### Can I use this serum with niacinamide, and in what order?

You can use this serum with niacinamide by applying niacinamide first and following with this treatment once it absorbs. This combination works well for your combination skin because it helps smooth texture and balance moisture without causing irritation. To achieve a better fit for your skin, this type of product also needs targeted oil-controlling ingredients like salicylic acid or zinc.

### How often should I use it?

You can use this treatment in your evening routine, as this helps keep things simple and safe around sun exposure. A product of this type needs peptides like acetyl hexapeptide-8 and hydroxypinacolone retinoate along with lightweight hydrators like glycerin and sodium hyaluronate to give your combination skin better results.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Can it clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts on combination skin. It features a gentle formulation without harsh ingredients, making it well-tolerated while smoothing texture and providing essential hydration.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/combination-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/combination-skin) — Average fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Amazon.ca: CA$145.00 (https://www.amazon.ca/dp/B09FG8TJDD?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- Sephora: CA$102.00 (https://www.sephora.com/ca/en/product/clinique-smart-clinical-repair-trade-wrinkle-correcting-serum-P473267?skuId=2480705)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Dimethicone, Isododecane, Butylene Glycol, Glycerin, Polysilicone-11, Ascorbyl Glucoside, Sodium Hyaluronate, Tocopheryl Acetate, Squalane, Hypnea Musciformis Extract Algae Extract, Gelidiella Acerosa Extract, Sigesbeckia Orientalis Extract, Helianthus Annuus Seed Extract Sunflower Seed Extract, Hordeum Vulgare Extract, Wheat Extract Germ Extract, Cucumis Sativus Fruit Extract, Caffeine, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Peg-10 Dimethicone, Glycyrrhetinic Acid, Whey Lactis Protéine Du Petit-Lait Protein, Isohexadecane, Propylene Glycol Dicaprate, Caprylyl Glycol, Hydroxypinacolone Retinoate, Acetyl Glucosamine, Cholesterol, Peg-8, Yeast Faex Extrait De Levure Extract, Peg-6, Dimethyl Isosorbide, Glyceryl Polymethacrylate, Polysorbate 20, Sodium Phosphate, Synthetic Fluorphlogopite, Polysorbate 80, Carbomer, Hexylene Glycol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, Potassium Hydroxide, Tin Oxide, Disodium Phosphate, Citric Acid, Disodium Edta, Sodium Citrate, Phenoxyethanol, Potassium Sorbate, Titanium Dioxide Ci 77891
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/combination-skin