# CLEARSTEM CELLRENEW Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [CLEARSTEM](https://lovi.care/skincare/ca/brands/clearstem)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, this serum utilizes Camellia Sinensis and Ganoderma Lucidum to help control sebum production and reduce oily shine.
- Antioxidants and sodium hyaluronate provide excellent hydration and protection against environmental stressors, further benefiting your skin.
- The formula is safe for your skin, as it contains soothing ingredients like Camellia Sinensis and Aloe Barbadensis and lacks any harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Ganoderma Lucidum, Bio-Available Collagen Cells Stem, Antioxidants, Curcuma Longa

## What the research says

- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Small extracellular vesicles derived from Aloe vera peels exhibited antioxidant activity, reduced intracellular ROS levels, enhanced human skin cell migration, and upregulated antioxidant-related gene expression in H2O2-treated human keratinocytes. ([Tissue Engineering and Regenerative Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34313971/))
- Ferulic acid exhibits low toxicity, diverse physiological functions including antioxidant and anti-inflammatory effects, and protects skin structures, though its application is limited by rapid oxidation. ([Skin Pharmacology and Physiology, 2018](https://pubmed.ncbi.nlm.nih.gov/30235459/))
- Topical application of (-)-epigallocatechin-3-gallate (EGCG) to human skin before UV irradiation decreases UV-induced production of hydrogen peroxide by 68-90% and nitric oxide by 30-100%, inhibits leukocyte infiltration and lipid peroxidation by 41-84%, and restores glutathione levels and glutathione peroxidase activity compared to UV exposure alone. ([Carcinogenesis, 2001](https://pubmed.ncbi.nlm.nih.gov/11181450/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of soap enriched with Ganoderma lucidum and goat's milk for 3 days resulted in almost complete regression of annular cutaneous sarcoidosis lesions in a 44-year-old male patient. ([Dermatology and Therapy, 2016](https://pubmed.ncbi.nlm.nih.gov/26868374/))
- Ganoderma lucidum polysaccharides at concentrations of 10, 20, and 40 ΓΖg/mL significantly increased fibroblast viability, migration, and CICP and TGF-Β1 expression compared to the control group, and external use in mice significantly increased wound healing rates and reduced healing time. ([Chinese Journal of Integrative Medicine, 2019](https://pubmed.ncbi.nlm.nih.gov/30552545/))
- Ethanolic extracts of Ganoderma lucidum rich in triterpenoids and phenolic acids exhibit antioxidant, anti-inflammatory, antityrosinase, antimicrobial, and cytotoxic effects, and can be successfully incorporated into topical cosmeceutical formulations while preserving their bioactivities. ([Food and Chemical Toxicology, 2017](https://pubmed.ncbi.nlm.nih.gov/28760544/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))

## What reviewers say

Based on a very large amount of data, users with acne-prone, sensitive, and reactive skin highly praise this product for calming inflammation, improving hydration, and supporting skin barrier repair. Many report smoother texture and reduced redness. Some users note it is a gentle, long-term support product rather than an overnight solution for deep-seated skin concerns.

- Liked: Acne-safe formula (mostly mentioned)
- Liked: Calms inflammation (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Deeply hydrating (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Slow visible results (sometimes noted)
- Disliked: Insufficient for severe acne (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes CLEARstem CELLRENEW Serum a great fit for combination skin?

CLEARstem CELLRENEW Serum is a great fit for combination skin because it uses ingredients like green tea and reishi mushroom to help control oily shine and balance sebum production. It also provides great hydration and protection from environmental stress while keeping skin calm and safe without harsh substances.
Sources: [Carcinogenesis, 2001](https://pubmed.ncbi.nlm.nih.gov/11181450/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Which ingredients make this serum a good fit for combination skin?

This serum is a great fit for your combination skin because it uses green tea and reishi mushroom to help control oil and reduce shine. Sodium hyaluronate and antioxidants also provide deep hydration while protecting your skin from daily environmental stressors.
Sources: [Carcinogenesis, 2001](https://pubmed.ncbi.nlm.nih.gov/11181450/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### What does Reishi Mushroom Extract do for combination skin?

Reishi Mushroom Extract helps balance combination skin by calming redness, fighting oxidative stress, and supporting skin barrier health. It may also reduce excess oil and soothe dry patches, making it a versatile addition to your routine. A product for this skin type needs soothing and antioxidant ingredients like niacinamide or green tea extract to keep both dry and oily areas smooth and comfortable.
Sources: [International Journal of Medicinal Mushrooms, 2022](https://pubmed.ncbi.nlm.nih.gov/35993963/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40762221/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and before moisturizing, though some serums may also be used in the morning or twice a day. Applying it at night helps keep things simple and provides extra safety around sun exposure.

### Can I use it with retinol, and in what order?

CLEARstem CELLRENEW Serum can be used in the same routine with retinol by applying the serum first to let its soothing and hydrating ingredients settle, followed by your retinol. The formula is safe for your skin and contains calming ingredients like Camellia Sinensis and Aloe Barbadensis, which are unlikely to cause irritation when paired properly.

### How often should I use this serum?

This serum is used in your evening routine, applying it then for simplicity and extra safety around sun exposure. People who tolerate it well and see good results may carefully use treatments more often.

### Can it clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts on your combination skin because it features soothing ingredients like Camellia Sinensis and aloe barbadensis and lacks harsh substances.
Sources: [Tissue Engineering and Regenerative Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34313971/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/combination-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/combination-skin) — Average fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Antioxidants, Camellia Sinensis, Sodium Hyaluronate, Ganoderma Lucidum, Curcuma Longa, Trifolium Pratense, Peppermint Essence, Curcuma Extract, Aloe Barbadensis, Panthenol B5, Bio-Available Collagen Cells Stem, Kunzea Pomifera Fruit Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/clearstem/cellrenew-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/clearstem/cellrenew-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/clearstem/cellrenew-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/clearstem/cellrenew-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/clearstem/cellrenew-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/clearstem/cellrenew-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/clearstem/cellrenew-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/clearstem/cellrenew-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/clearstem/cellrenew-serum/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/clearstem/cellrenew-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/clearstem/cellrenew-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/clearstem/cellrenew-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/clearstem/cellrenew-serum/for/combination-skin