# Caudalie Premier Cru The Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/caudalie/premier-cru-the-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Caudalie](https://lovi.care/skincare/ca/brands/caudalie)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, this serum effectively addresses acne and breakouts with niacinamide to regulate oil and reduce inflammation, while Ribose and Hydrolyzed Hyaluronic Acid provide plumping and minimize fine lines.
- Glycerin further supports hydration in your combination skin, ensuring a balanced and comfortable feel.
- The formula is safe for your skin, containing no harsh or irritating ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/caudalie/premier-cru-the-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/caudalie/premier-cru-the-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/caudalie/premier-cru-the-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/caudalie/premier-cru-the-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/caudalie/premier-cru-the-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/ca/p/caudalie/premier-cru-the-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/caudalie/premier-cru-the-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/caudalie/premier-cru-the-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/caudalie/premier-cru-the-serum/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Sodium Hyaluronate, Palmitoyl Grapevine Shoot Extract, Viniferine, Polyphenols

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Polyelectrolyte nanocomplexes of quaternized cyclodextrin grafted chitosan and low molecular weight hyaluronic acid improved skin texture and elasticity by increasing skin hydration in clinical evaluation. ([Colloids and Surfaces. B, Biointerfaces, 2022](https://pubmed.ncbi.nlm.nih.gov/36279763/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A combination of Vitis vinifera shoot extract and a biotechnological extract demonstrated significant in vitro and in vivo antioxidant effects and improved clinical signs of photoaged skin in female subjects after a 4-week application. ([Journal of Drugs in Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17691204/))
- Pre-treatment with Vitis vinifera L. water extract (100 ΓΙg/mL) demonstrated antioxidant and scavenger activity against UV-A radiation and exerted an anti-mutagenic effect by maintaining apoptosis in UV-A and UV-B irradiated human keratinocytes (HaCaT). ([Journal of Photochemistry and Photobiology. B, Biology, 2020](https://pubmed.ncbi.nlm.nih.gov/32028189/))
- A water extract from grapevine leaves inhibited proinflammatory-induced interleukin-8 and vascular endothelial growth factor secretion in human keratinocytes compared to untreated challenged cells. ([Antioxidants, 2019](https://pubmed.ncbi.nlm.nih.gov/31100904/))

## What reviewers say

Based on a very large amount of data, users with dry, mature, and sensitive skin frequently praise this serum for its immediate hydrating and plumping effects, often noting a visible reduction in fine lines and a brighter complexion. While the lightweight texture and "healthy glow" are widely appreciated, results regarding deep wrinkles vary, and the scent is a polarizing feature.

- Liked: Deep hydration & plumping (mostly mentioned)
- Liked: Lightweight, silky texture (often mentioned)
- Liked: Visible skin improvement (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Luxurious experience (sometimes noted)
- Disliked: Strong fragrance (sometimes noted)
- Disliked: Lack of dramatic results (rarely noted)
- Disliked: Texture suitability (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Caudalie Premier Cru The Serum a great fit for acne-prone skin?

Caudalie Premier Cru The Serum is a great fit because it contains niacinamide to regulate oil and calm breakouts, alongside hydrating ingredients like glycerin and sodium hyaluronate to keep your skin balanced and comfortable. This formula is safe for acne-prone skin, as it contains no harsh or irritating ingredients.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit because it contains niacinamide to regulate oil and calm breakouts, along with glycerin and sodium hyaluronate to keep skin hydrated and balanced.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in the evening routine for acne-prone skin, after cleansing and before moisturizing, to keep things simple and safe around sun exposure. Niacinamide helps regulate oil and reduce inflammation to manage breakouts.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help keep your skin balanced, followed by your retinol. This approach is unlikely to cause irritation because the formula avoids harsh ingredients.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This serum is a great fit for your acne-prone skin and is best used in the evening as part of your routine. This timing helps keep things simple and safe around sun exposure, while niacinamide regulates oil and reduces inflammation.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Colloids and Surfaces. B, Biointerfaces, 2022](https://pubmed.ncbi.nlm.nih.gov/36279763/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for acne-prone skin because it contains niacinamide to regulate oil and reduce inflammation. The formula is safe for your skin, containing no harsh or irritating ingredients that typically trigger breakouts.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, geraniol, linalool, and citronellol).

## Alternatives for acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/acne-prone-skin) — High fit — CA$27.99 at Amazon
- [ANUA PEACH 70% NIACINAMIDE SERUM](https://lovi.care/skincare/ca/p/anua/peach-70-niacinamide-serum/for/acne-prone-skin) — High fit — CA$33.50 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/ca/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — CA$22.95 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — CA$41.00 at Amazon
- Moisturizer: [CeraVe CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/ca/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — CA$20.96 at Amazon

## Where to buy

- Amazon.ca: CA$168.00 (https://www.amazon.ca/dp/B0DM3JH5PX?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- Sephora: CA$168.00 (https://www.sephora.com/ca/en/product/caudalie-premier-cru-anti-aging-serum-P480284?skuId=2838266)
Prices checked 12 Oct – 3 Nov 2026.

## Ingredients

Water, Glycerin, Propanediol, Niacinamide, Methylpropanediol, Betaine, Ribose, Hydrolyzed Hyaluronic Acid, Paeonia Albiflora Root Extract, Sodium Hyaluronate, Palmitoyl Grape Seed Extract, Palmitoyl Grapevine Shoot Extract, Caprylyl Glycol, Carbomer, Polyacrylate Crosspolymer-6, Helianthus Annuus Seed Oil Sunflower Seed Oil, Tocopherol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Phenylpropanol, Sodium Carboxymethyl Beta-Glucan, Sorbitan Isostearate, Parfum, Sodium Phytate, Sodium Hydroxide, Geraniol, Linalool, Citronellol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/caudalie/premier-cru-the-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/caudalie/premier-cru-the-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/caudalie/premier-cru-the-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/caudalie/premier-cru-the-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/caudalie/premier-cru-the-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/caudalie/premier-cru-the-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/caudalie/premier-cru-the-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/caudalie/premier-cru-the-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/caudalie/premier-cru-the-serum/for/acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/caudalie/premier-cru-the-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/caudalie/premier-cru-the-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/caudalie/premier-cru-the-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/caudalie/premier-cru-the-serum/for/acne-prone-skin