# Biossance Squalane + Vitamin C Dark Spot Serum for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Biossance](https://lovi.care/skincare/ca/brands/biossance)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin, this serum effectively brightens and evens skin tone with 3-O-Ethyl Ascorbic Acid and Glycerin, while Glycyrrhiza Glabra Root Extract offers moderate soothing benefits for redness and irritation.
- The formulation is safe for your sensitive skin, containing no harsh ingredients that could cause irritation.
- Overall, the product provides relevant benefits for your skin concerns and type.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/oily-acne-prone-skin): Superior

## Key ingredients

Ascorbic Acid, Squalane, White Shiitake Mushroom Extract, Licorice Root Extract, Sodium Hyaluronate

## What the research says

- A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Lentinan reduced benzo(a)pyrene-induced oxidative stress, malondialdehyde levels, and inflammatory cytokine production while increasing antioxidant enzyme activities in human keratinocytes. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31135098/))
- Shiitake mushroom ethanol extract exhibited moderate antioxidant capacity, 51.99% elastase inhibition, concentration-dependent collagenase suppression, and non-toxicity in human keratinocytes, supporting its safe incorporation into stable topical anti-aging skin-care formulations. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41656649/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Based on a very large amount of data, this serum is frequently praised for its lightweight, milky texture that hydrates while effectively brightening dull complexions and fading acne scars over time. Many with sensitive skin find it gentle and non-irritating, although a subset of users experienced no visible changes in pigmentation or suffered severe allergic reactions like redness and swelling.

- Liked: Brightens complexion (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Hydrating texture (often mentioned)
- Liked: Gentle formula (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Allergic reactions (rarely noted)
- Disliked: Poor packaging (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Biossance Squalane + Vitamin C Dark Spot Serum a great fit for sensitive skin?

This serum is a great fit for sensitive skin because it brightens uneven skin tone safely without harsh ingredients that might cause irritation, while licorice root extract helps calm redness. It is unlikely to trigger stinging, making it comfortable for daily use.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/)

### Which ingredients make this serum a good fit for sensitive skin?

This serum is a great fit because it contains Glycyrrhiza Glabra Root Extract, which helps soothe redness and irritation on sensitive skin. It is also formulated without harsh ingredients, making it safe and gentle for daily use.

### What does Vitamin C do for sensitive skin?

Vitamin C helps brighten skin, smooth out fine lines, and fade dark spots. Clinical studies show it is generally safe and well-tolerated when improving overall skin quality.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Squalane do for sensitive skin?

Squalane helps calm sensitive skin by defending against everyday irritation and keeping it smooth and soft. It is unlikely to cause irritation and supports your skin barrier so it stays comfortable and hydrated.
Sources: [International Journal of Molecular Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/29280987/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine for sensitive skin, helping to keep things simple and safe around sun exposure. It fits into the routine after cleansing and toning, and right before moisturizing.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment first in your evening routine and following with a moisturizer, while introducing them slowly to keep your sensitive skin calm and comfortable.

### How often should I use this serum?

Apply this treatment in the evening, using it once a week at first and carefully working up to more often if your skin tolerates it well. This gradual routine helps keep your skin calm while delivering effective brightening benefits.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is a great fit for your sensitive skin because it is formulated without harsh ingredients that typically cause irritation or breakouts. While allergic reactions are rare, some users notice no visible results, and it helps brighten your skin tone smoothly and safely.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/sensitive-skin) — High fit — CA$33.98 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin) — High fit — CA$24.44 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/sensitive-skin) — High fit — CA$14.40 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — CA$44.95 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — CA$27.34 at Amazon

## Where to buy

- Sephora: CA$90.00 (https://www.sephora.com/ca/en/product/biossance-squalane-vitamin-c-dark-spot-serum-P467110?skuId=2404655)
Prices checked 10 Oct 2026.

## Ingredients

Water, Glycerin, 3-O-Ethyl Ascorbic Acid, Squalane, Lentinus Edodes Mycelium Extract, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Sodium Hyaluronate, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Xanthan Gum, Sodium Gluconate, Sodium Citrate, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin