# Biossance Squalane + Vitamin C Dark Spot Serum for dry skin

**Lovi Fit: Superior fit for dry skin.**
Dry Skin Fit: High · Effectiveness: Superior · Safety: High.

Page: https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Biossance](https://lovi.care/skincare/ca/brands/biossance)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for dry skin.

## Why this fit

- Offers excellent brightening and evening of skin tone for you due to the presence of 3-O-Ethyl Ascorbic Acid and Glycyrrhiza Glabra Root Extract, which visibly reduce dark spots and hyperpigmentation. This serum also provides significant hydration for your dry or flaky skin, with Glycerin and Sodium Hyaluronate offering moisturizing benefits.
- The formula is highly suitable for your dry skin, as Glycerin and Sodium Hyaluronate act as humectants, while Squalane provides emollient action.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of harsh ingredients and the inclusion of soothing agents like Glycerin and Squalane.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin): Superior (this page)
- [Combination skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/oily-acne-prone-skin): Superior

## Key ingredients

Ascorbic Acid, Squalane, White Shiitake Mushroom Extract, Licorice Root Extract, Sodium Hyaluronate

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Lentinan reduced benzo(a)pyrene-induced oxidative stress, malondialdehyde levels, and inflammatory cytokine production while increasing antioxidant enzyme activities in human keratinocytes. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31135098/))
- Shiitake mushroom ethanol extract exhibited moderate antioxidant capacity, 51.99% elastase inhibition, concentration-dependent collagenase suppression, and non-toxicity in human keratinocytes, supporting its safe incorporation into stable topical anti-aging skin-care formulations. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41656649/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Based on a very large amount of data, this serum is frequently praised for its lightweight, milky texture that hydrates while effectively brightening dull complexions and fading acne scars over time. Many with sensitive skin find it gentle and non-irritating, although a subset of users experienced no visible changes in pigmentation or suffered severe allergic reactions like redness and swelling.

- Liked: Brightens complexion (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Hydrating texture (often mentioned)
- Liked: Gentle formula (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Allergic reactions (rarely noted)
- Disliked: Poor packaging (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Biossance Squalane + Vitamin C Dark Spot Serum one of the best fits for dry skin?

This serum is one of the best fits because it brightens uneven skin tone while deeply quenching dry, flaky areas with intensive moisture. It keeps skin soft and comfortable by pairing soothing agents with moisturizing ingredients that trap water and smooth out rough spots, all while maintaining an exceptionally gentle safety profile.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry skin?

Glycerin and Sodium Hyaluronate draw in moisture while Squalane softens your dry skin. These ingredients keep your skin hydrated and comfortable without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Vitamin C do for dry skin?

Vitamin C helps dry skin by boosting moisture and keeping the surface smooth and soft. It may also improve skin hydration and support the outer protective barrier over time.
Sources: [Skin Research and Technology, 2008](https://pubmed.ncbi.nlm.nih.gov/19159387/), [Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/)

### What does Squalane do for dry skin?

Squalane helps keep dry skin soft and smooth by acting as a hydrating agent that locks in moisture and prevents water loss. It is unlikely to cause irritation and may protect the skin from damage while improving overall hydration.
Sources: [Advances in Food and Nutrition Research, 2012](https://pubmed.ncbi.nlm.nih.gov/22361190/), [Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and avoids extra sensitivity around sun exposure. Using this vitamin C serum helps improve brightness while the added squalane and glycerin provide deep hydration for dry skin.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your dry skin a boost of hydration, followed by retinol once it absorbs. This formula is unlikely to cause irritation because it includes soothing ingredients and avoids harsh components.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

This serum is used in the evening as part of your routine. It is unlikely to cause irritation on dry skin and helps keep your skin hydrated.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to cause breakouts or clog pores on dry skin because it features soothing ingredients like squalane and glycerin and has an excellent safety profile without harsh irritants. It also helps keep your skin soft and hydrated.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/ca/p/kravebeauty/great-barrier-relief/for/dry-skin) — Superior fit — CA$40.00 at Amazon
- [SKIN1004 Madagascar Centella Tone Brightening Capsule Ampoule](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-tone-brightening-capsule-ampoule/for/dry-skin) — Superior fit — CA$22.49 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/dry-skin) — Superior fit — CA$14.40 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ca/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — CA$20.19 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/ca/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — CA$27.99 at Amazon
- Moisturizer: [Tata Harper Repairative Moisturizer](https://lovi.care/skincare/ca/p/tata-harper/repairative-moisturizer/for/dry-skin) — Superior fit — CA$162.00 at Amazon

## Where to buy

- Sephora: CA$90.00 (https://www.sephora.com/ca/en/product/biossance-squalane-vitamin-c-dark-spot-serum-P467110?skuId=2404655)
Prices checked 10 Oct 2026.

## Ingredients

Water, Glycerin, 3-O-Ethyl Ascorbic Acid, Squalane, Lentinus Edodes Mycelium Extract, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Sodium Hyaluronate, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Xanthan Gum, Sodium Gluconate, Sodium Citrate, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin (this page)
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin