# Biossance Squalane + Vitamin C Dark Spot Serum for dry sensitive skin

**Lovi Fit: Superior fit for dry sensitive skin.**
Dry Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Biossance](https://lovi.care/skincare/ca/brands/biossance)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for dry sensitive skin.

## Why this fit

- Offers excellent brightening and hydration for your dry and sensitive skin, as high concentrations of 3-O-Ethyl Ascorbic Acid and Glycyrrhiza Glabra Root Extract visibly improve skin tone while Glycerin and Sodium Hyaluronate provide essential moisture.
- Squalane and Licorice Root Extract further enhance soothing and emollient benefits, making it exceptionally well-suited for dry or flaky skin.
- The formulation is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of calming components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin): Superior (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/oily-acne-prone-skin): Superior

## Key ingredients

Ascorbic Acid, Squalane, White Shiitake Mushroom Extract, Licorice Root Extract, Sodium Hyaluronate

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Lentinan reduced benzo(a)pyrene-induced oxidative stress, malondialdehyde levels, and inflammatory cytokine production while increasing antioxidant enzyme activities in human keratinocytes. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31135098/))
- Shiitake mushroom ethanol extract exhibited moderate antioxidant capacity, 51.99% elastase inhibition, concentration-dependent collagenase suppression, and non-toxicity in human keratinocytes, supporting its safe incorporation into stable topical anti-aging skin-care formulations. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41656649/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Based on a very large amount of data, this serum is frequently praised for its lightweight, milky texture that hydrates while effectively brightening dull complexions and fading acne scars over time. Many with sensitive skin find it gentle and non-irritating, although a subset of users experienced no visible changes in pigmentation or suffered severe allergic reactions like redness and swelling.

- Liked: Brightens complexion (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Hydrating texture (often mentioned)
- Liked: Gentle formula (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Allergic reactions (rarely noted)
- Disliked: Poor packaging (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Biossance Squalane + Vitamin C Dark Spot Serum one of the best fits for dry sensitive skin?

This serum is one of the best fits for your dry sensitive skin because it offers excellent brightening and hydration while soothing easily irritated areas. Ascorbic acid and licorice root extract improve uneven skin tone, while squalane, glycerin, and sodium hyaluronate lock in essential moisture to keep skin soft and smooth.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Glycerin, sodium hyaluronate, squalane, and licorice root extract make this serum a great fit by delivering essential moisture and soothing benefits to dry and sensitive skin. Additionally, vitamin C helps brighten skin tone safely without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What does Vitamin C do for dry sensitive skin?

Vitamin C helps brighten and smooth dry sensitive skin while reducing wrinkles and improving elasticity. It is generally well tolerated and unlikely to cause irritation when properly formulated, leaving the skin looking more radiant.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38397772/)

### What does Squalane do for dry sensitive skin?

Squalane helps keep dry sensitive skin soft and smooth by locking in moisture and calming irritation without causing flare-ups. It is unlikely to cause redness or discomfort, making it a gentle choice that supports the skin barrier. This type of skin needs ingredients that deeply hydrate and soothe, such as plant oils and antioxidants.
Sources: [International Journal of Molecular Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/29280987/), [Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This treatment serum goes in your evening routine after your toner and before your moisturizer. Putting it in the evening keeps things simple and avoids extra sun sensitivity, while calming ingredients help ensure your dry and sensitive skin stays comfortable.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying the serum first in your evening routine and following with a gentle moisturizer, or by using them on alternate nights to keep sensitive skin calm. This helps deliver brightening vitamin C while minimizing potential irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### How often should I use this serum?

This serum works best in your evening routine, starting at once a week to see how your skin feels. Because it is gentle and hydrating, you may eventually use it more often if your skin tolerates it well.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores or cause breakouts for dry sensitive skin. Its lightweight formula focuses on providing moisture and soothing benefits without using heavy ingredients that typically cause congestion.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/ca/p/kravebeauty/great-barrier-relief/for/dry-sensitive-skin) — High fit — CA$40.00 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/dry-sensitive-skin) — High fit — CA$14.40 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/dry-sensitive-skin) — High fit — CA$24.44 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/ca/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — CA$20.19 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ca/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — CA$49.00 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/ca/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — CA$38.00 at Amazon

## Where to buy

- Sephora: CA$90.00 (https://www.sephora.com/ca/en/product/biossance-squalane-vitamin-c-dark-spot-serum-P467110?skuId=2404655)
Prices checked 10 Oct 2026.

## Ingredients

Water, Glycerin, 3-O-Ethyl Ascorbic Acid, Squalane, Lentinus Edodes Mycelium Extract, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Sodium Hyaluronate, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Xanthan Gum, Sodium Gluconate, Sodium Citrate, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin (this page)
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-vitamin-c-dark-spot-serum/for/dry-sensitive-skin