Biossance Squalane + Ectoin Overnight Rescue for sensitive skin
Squalane
Ectoin
Glycerin
Shorea Stenoptera Seed Butter
Acetyl Hexapeptide-8
High
- HighNormal Skin Fit
- HighEffectiveness
- ExcellentSafety
A great choice for sensitive skin; a few moisturizers fit it even better.
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers excellent moisturizing for your normal skin, as squalane and ectoin hydrate and enhance barrier resilience, directly addressing your redness and irritation.
- The formula provides moderate suitability for normal skin by offering emollient and protective actions, though it may not deliver optimal results in all areas.
- The safety profile is excellent, with no risks of irritation for your sensitive skin due to the absence of harsh ingredients and the presence of soothing ectoin.
How to apply
- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
People Say
★4.6Overall rating based on 2.0k+ reviewsMost users report waking up to soft, plump, and soothed skin without irritation. Those with oily or acne-prone skin occasionally find the formula too rich. This summary is based on a very large amount of data and should definitely be taken into account.
Highlights
Deeply hydrating Mostly Mentioned
- “My skin loves and drinks this right up.”
- “It keeps my face hydrated until morning.”
- “This is the first cream that has helped with my dry skin.”
- “Hydrates me very well overnight.”
Absorbs well Often Mentioned
- “Absorbs right in without the need to overly blend it in.”
- “It is not greasy at all like serums can be.”
- “Melts into your skin so easily and effortlessly.”
- “Absorbs quickly and leaves no greasy residue or film.”
Plumps and softens Often Mentioned
- “Wake up with plump, moisturized, healthy-looking skin.”
- “Makes my skin look super plump, glowing, and helps it to feel very soft.”
- “I wake up in the morning to baby smooth skin.”
- “Always makes my skin feeling so soft as soon as I put it on.”
Soothes sensitive skin Often Mentioned
- “There is no stinging, irritation or redness when using this product.”
- “I have very sensitive skin and this has been great for my skin.”
High price point Sometimes Noted
- “Seventy dollars for one small jar is a steep ask.”
- “Seventy dollars buys a single fifty-milliliter jar.”
- “Asks you to pay a premium.”
Heavy or greasy Rarely Noted
- “Consistency leaves a greasy feel to the skin.”
- “The overnight rescue is by far one of the thickest creams I have ever used.”
- “Heaviness, or a greasy feel may occur for some users.”
- “Oily and breakout-prone complexions will likely find it too rich.”
Jar packaging Rarely Noted
- “As always, a jar means scooping.”
- “Which is a small hygiene knock.”
- “The frosted glass jar is attractive but... a jar means scooping.”
May cause breakouts Rarely Noted
- “A few reviews mention that breakouts... may occur for some users.”
- “Not formulated to be fungal-acne safe.”
- “Oily and breakout-prone complexions will likely find it too rich.”
Sources: lovi.care, sephora.com, biossance.com, influenster.com, dermapproved.com, cultbeauty.co.uk, and more
Questions and answers
What makes Biossance Squalane + Ectoin Overnight Rescue a great fit for sensitive skin?
Biossance Squalane + Ectoin Overnight Rescue is a great fit for sensitive skin because it offers wonderful moisture while helping calm redness and irritation. Its very safe formula avoids harsh ingredients and includes soothing ectoin, which helps keep your skin feeling calm and comfortable without irritation.
Which ingredients make this cream a good fit for sensitive skin?
Squalane and ectoin make this cream a great fit for sensitive skin by giving deep moisture and strengthening your skin barrier to calm redness and irritation. Because the formula lacks harsh ingredients and includes soothing ectoin, it has an excellent safety profile with very low risk of irritation.
What does Squalane do for sensitive skin?
Squalane helps calm sensitive skin by defending against everyday irritation and keeping it smooth and soft. It is unlikely to cause irritation and supports your skin barrier so it stays comfortable and hydrated.
What does Ectoin do for sensitive skin?
Ectoin helps calm sensitive skin by strengthening the skin barrier, reducing water loss, and protecting against irritation. It acts as a gentle shield to keep skin hydrated and comfortable.
European Journal of Dermatology, 2025Clinics in Dermatology, 2008
Where does this cream go in a skincare routine for sensitive skin?
This treatment goes in your evening routine after your soothing toner and before your moisturizer. It is a great fit for your sensitive skin because squalane and ectoin hydrate and protect your skin barrier while soothing redness and irritation with very low risk of irritation.
Can I use this cream with retinol, and in what order?
You can use this moisturizing treatment with retinol by applying the retinol first at night, letting it absorb, and then following with the cream to help calm and protect your skin. This formula has an excellent safety profile with soothing ectoin, making it unlikely to cause irritation when paired with stronger treatments.
How often should I use this cream?
This moisturizing treatment is designed for evening use as part of your routine for sensitive skin. Daily application is unlikely to cause irritation and helps improve hydration and calm redness.
Can this cream clog pores, cause breakouts or purging for sensitive skin?
This cream is unlikely to cause breakouts or clog pores for sensitive skin, as reviewers rarely report heavy or greasy feelings or breakouts. Its formula avoids harsh ingredients and includes soothing ectoin to maintain a safe and comfortable experience.
Can I use this cream around the eyes or on my body?
You can use this moisturizing treatment around the eyes and on your body because its gentle formula has an excellent safety profile with no risks of irritation for sensitive skin.
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Combining ectoine and mannitol with UV filters significantly improved protection of squalene oxidation, catalase activity, and trans-UCA compared to UV filters alone in 10 subjects on irradiated areas.
Journal of Cosmetic Dermatology, 2024Topical 7% ectoine during serial 1064-nm Nd:YAG laser therapy produced a greater reduction in skin erythema, improved stratum corneum hydration, reduced transepidermal water loss, and decreased low-echogenic pixels in thirty participants compared to a vehicle control.
Biomedicines, 2026Regular application of a novel anti-ageing cream containing hyaluronic acid, ectoin, and botanical actives significantly reduced wrinkle depth and length in the periorbital area while demonstrating very good skin tolerance.
Polymers, 2023The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017
Ingredients
Water, Glycerin, Squalane, Shorea Stenoptera Seed Butter, Caprylic Capric Triglyceride, C12-16 Alcohols, Sodium Acrylates Copolymer, Ectoin, Jojoba Esters, Acetyl Hexapeptide-8, Magnesium Chloride, Palmitic Acid, Hydrogenated Lecithin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Lecithin, Sorbitan Isostearate, Tocopherol, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Sodium Gluconate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.