# Biossance Squalane + Copper Peptide Rapid Plumping Serum for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Biossance](https://lovi.care/skincare/ca/brands/biossance)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for skin with dark spots.

## Why this fit

- Highly suitable for your normal skin, this serum utilizes squalane and sodium hyaluronate to provide excellent emollient and humectant actions, maintaining your skin's hydration and barrier function.
- The inclusion of copper peptides and ectoin offers moderate effectiveness for your pigmentation concerns, working to improve skin elasticity and overall tone.
- The product is safe for your normal skin, featuring soothing ingredients like Ectoin and Camellia Sinensis Leaf Extract with no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/mature-skin): Low
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin): High

## Key ingredients

Squalane, Copper Peptides, Sodium Hyaluronate, Acmella Oleracea Extract, Panthenol

## What the research says

- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Enzymatic alpha glucosylation of EGCG yielded EGCG-G1, which enhanced epidermal penetration, decreased melanogenesis through down-regulation of 13 genes including MITF, stimulated skin Lactobacillus growth, and decreased hyperpigmented spots while increasing skin brightness and homogeneity compared to EGCG and vitamin C across a large panel of phototypes. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/39598779/))
- Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo. ([Experimental Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/18631247/))
- An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31239743/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- An Acmella oleracea extract-loaded glycolipid emulsion serum applied topically demonstrated safety with no ocular irritation or systemic dermal absorption, alongside significant improvements in facial skin hydration, smoothness, and reductions in roughness, scaliness, and wrinkles. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/))
- A novel formulation containing supramolecular retinol plus acmella oleracea extract significantly reduced dark circles by 13.8% in melanin index, decreased fine wrinkles, and increased skin firmness by 13.0% in 33 Chinese urban women after 6 weeks of use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34806292/))
- The optimized squalane-based spilanthol emulsion achieved a maximum skin retention of 118.71 μg/g and restored skin hydroxyproline content to 23.99 μg/g, outperforming positive and negative groups due to high drug release and miscibility driven by weak Van der Waals interactions. ([AAPS PharmSciTech, 2019](https://pubmed.ncbi.nlm.nih.gov/31222590/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))

## What reviewers say

Based on a very large amount of data, this serum is widely praised for its ability to deliver instant hydration and a visible plumping effect, making it a favorite for users with dry, dehydrated, or aging skin. The majority of users report a lightweight texture that absorbs well and improves skin bounce. A minority experience stickiness or find the high price point unjustifiable for the results achieved.

- Liked: Intense hydration (mostly mentioned)
- Liked: Elegant texture (often mentioned)
- Liked: Visible plumping (often mentioned)
- Liked: Improved texture (sometimes noted)
- Liked: Soothing properties (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Breakouts/Irritation (rarely noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Paradoxical drying (rarely noted)
- Disliked: Sticky after-feel (rarely noted)

## How to apply

- Could be used as part of your AM and PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it too hard so it absorbs nicely.
- For the best moisture, you can apply it when your skin is slightly damp. This helps your skin stay soft and happy.
- Remember to avoid the eye area when applying. Always do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Biossance Squalane + Copper Peptide Rapid Plumping Serum a great fit for skin with dark spots?

This serum is a great fit for skin with dark spots because it uses copper peptides and ectoin to help improve your overall tone and skin elasticity. It also keeps your skin deeply hydrated while soothing it with green tea extract, which is very safe and unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31239743/), [Experimental Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/18631247/)

### Which ingredients make this serum a good fit for skin with dark spots?

Copper peptides and green tea extract make this serum a good fit for skin with dark spots by helping to improve overall tone and brightness. Squalane and sodium hyaluronate also support the skin by maintaining your hydration and barrier function.
Sources: [Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/39598779/), [Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31239743/)

### What does Squalane do for skin with dark spots?

Squalane helps keep skin soft and smooth, but it is unlikely to directly fade dark spots on its own. For hyperpigmentation, this type of product needs added brightening ingredients like vitamin C or antioxidants to help even out skin tone.

### What do Copper Peptides do for skin with dark spots?

Copper Tripeptide-1 helps improve skin firmness and supports regeneration, but it is not typically known for directly fading dark spots. To effectively address dark spots, this type of product works best when combined with targeted brightening ingredients like vitamin C or niacinamide.
Sources: [BioMed Research International, 2015](https://pubmed.ncbi.nlm.nih.gov/26236730/)

### Where does this serum go in a skincare routine for skin with dark spots?

This serum goes in the evening routine after cleansing and before moisturizing, as treatments with active ingredients are best used at night for simplicity and extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to keep your skin hydrated while it adjusts to the treatment. This soothing formula is unlikely to cause irritation and may help support your skin barrier when using strong actives.

### How often should I use this serum?

You can use this serum in your evening routine, applying it after cleansing and before your moisturizer. It features soothing ingredients and a very safe profile, so it is unlikely to irritate your skin.

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is a great fit for your skin with dark spots and is unlikely to cause breakouts or irritation. It features soothing ingredients like green tea extract with a safe profile that helps keep skin calm.
Sources: [Experimental Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/18631247/), [Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31239743/)

### Can I use this serum around the eyes or on my body?

This moisturizing treatment is safe to use on the body and around the eyes, where the skin is particularly thin. Regular application in these areas helps improve skin tone and texture while maintaining a very good safety profile.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/ca/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/dark-spots) — High fit — CA$21.81 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/ca/p/missha/super-aqua-ultra-hyalron-ampoule/for/dark-spots) — Average fit — CA$37.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/ca/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — CA$23.99 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/ca/p/torriden/dive-in-mild-sunscreen/for/dark-spots) — Superior fit — CA$27.34 at Amazon

## Where to buy

- Sephora: CA$94.00 (https://www.sephora.com/ca/en/product/biossance-squalane-copper-peptide-rapid-plumping-serum-P479304?skuId=2536076)
Prices checked 16 Oct 2026.

## Ingredients

Water, Glycerin, Propanediol, Squalane, Sodium Hyaluronate, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Copper Tripeptide-1, Acmella Oleracea Extract, Ectoin, Tetrapeptide-30, Palmitoyl Hexapeptide-52, Copper Pca, Panthenol, Sodium Polyglutamate, Camellia Sinensis Leaf Extract, Aloe Barbadensis Flower Extract, Passiflora Incarnata Flower Extract, Melia Azadirachta Leaf Extract, Solanum Melongena Fruit Extract, Curcuma Longa Root Extract, Ocimum Basilicum Leaf Extract Flower, Coccinia Indica Fruit Extract, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Corallina Officinalis Extract, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Xanthan Gum, Phenoxyethanol, Ethylhexylglycerin, Citric Acid, Caprylyl Glycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots
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- Spain: https://lovi.care/skincare/es/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots (this page)
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots
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- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots