# Biossance Squalane + Copper Peptide Rapid Plumping Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Biossance](https://lovi.care/skincare/ca/brands/biossance)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- Excellent plumping for your combination skin is provided by sodium hyaluronate and copper tripeptide-1, which hydrate and improve elasticity while Acmella Oleracea Extract aids in skin repair and inflammation reduction for your acne concerns.
- Glycerin and squalane balance hydration without overwhelming oily areas, and the inclusion of aloe barbadensis flower extract offers soothing benefits.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/mature-skin): Low
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/oily-acne-prone-skin): High

## Key ingredients

Squalane, Copper Peptides, Sodium Hyaluronate, Acmella Oleracea Extract, Panthenol

## What the research says

- An Acmella oleracea extract-loaded glycolipid emulsion serum applied topically demonstrated safety with no ocular irritation or systemic dermal absorption, alongside significant improvements in facial skin hydration, smoothness, and reductions in roughness, scaliness, and wrinkles. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/))
- An all-natural anti-wrinkle emulsion serum containing Acmella oleracea extract demonstrated safe skin tolerability and reduced facial wrinkles in human volunteers after 2 weeks of application. ([International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/))
- An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31239743/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A novel formulation containing supramolecular retinol plus acmella oleracea extract significantly reduced dark circles by 13.8% in melanin index, decreased fine wrinkles, and increased skin firmness by 13.0% in 33 Chinese urban women after 6 weeks of use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34806292/))
- The optimized squalane-based spilanthol emulsion achieved a maximum skin retention of 118.71 μg/g and restored skin hydroxyproline content to 23.99 μg/g, outperforming positive and negative groups due to high drug release and miscibility driven by weak Van der Waals interactions. ([AAPS PharmSciTech, 2019](https://pubmed.ncbi.nlm.nih.gov/31222590/))
- Treatment with methanolic extract of Acmella oleracea leaves exerted potent antioxidant, anti-inflammatory, antimicrobial, and wound healing effects in vitro by reducing inflammatory mediators, scavenging free radicals, inhibiting bacterial growth, and enhancing fibroblast migration without inducing cytotoxicity. ([Journal of Ethnopharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/39357584/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## What reviewers say

Based on a very large amount of data, this serum is widely praised for its ability to deliver instant hydration and a visible plumping effect, making it a favorite for users with dry, dehydrated, or aging skin. The majority of users report a lightweight texture that absorbs well and improves skin bounce. A minority experience stickiness or find the high price point unjustifiable for the results achieved.

- Liked: Intense hydration (mostly mentioned)
- Liked: Elegant texture (often mentioned)
- Liked: Visible plumping (often mentioned)
- Liked: Improved texture (sometimes noted)
- Liked: Soothing properties (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Breakouts/Irritation (rarely noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Paradoxical drying (rarely noted)
- Disliked: Sticky after-feel (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Biossance Squalane + Copper Peptide Rapid Plumping Serum a great fit for acne-prone skin?

This serum is a great fit for your acne-prone skin because it hydrates and improves elasticity while helping calm inflammation and repair your skin. Glycerin and squalane balance hydration without overwhelming oily areas, and it is unlikely to cause irritation thanks to its gentle, soothing ingredients.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/), [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/)

### Which ingredients make this serum a good fit for acne-prone skin?

Sodium hyaluronate and copper tripeptide-1 hydrate and improve elasticity, while Acmella Oleracea Extract helps calm inflammation and repair your skin. Glycerin and squalane balance hydration without feeling heavy, and soothing aloe vera extract adds extra comfort for breakout-prone areas.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/), [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/)

### What does Squalane do for acne-prone skin?

Squalane may help keep acne-prone skin soft and smooth, but peroxidated forms can trigger inflammation in skin cells. For a better fit on acne-prone skin, products need non-clogging, soothing ingredients that balance oil without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16778793/)

### What do Copper Peptides do for acne-prone skin?

Copper tripeptide-1 GHK-Cu helps acne-prone skin by reducing redness and soothing inflammation while protecting against damage. It also helps improve overall skin barrier health.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. It is a great fit because glycerin and squalane balance hydration without overwhelming oily areas, while soothing components help calm inflammation.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help keep your skin calm and hydrated. Using a soothing, barrier-friendly product alongside retinoids is unlikely to cause irritation and may help your skin adjust more comfortably.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/)

### How often should I use this serum?

This serum is a great fit for your acne-prone skin and is safely used in your evening routine. Daily application helps hydrate and calm your skin while keeping oily areas balanced without irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause breakouts or clog pores on acne-prone skin. Glycerin and squalane balance hydration without overwhelming oily areas, while Acmella Oleracea Extract helps calm inflammation and soothe your skin.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/), [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/)

### Can I use this serum around the eyes or on my body?

Yes, you can use this serum around the eyes and on your body because its gentle formula hydrates and smooths safely without causing irritation. It helps improve skin texture and elasticity in delicate areas.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39617635/), [International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34297422/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/ca/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin) — Average fit — CA$37.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/ca/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — CA$22.95 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — CA$41.00 at Amazon
- SPF: [innisfree Daily UV Defense Mineral Sunscreen](https://lovi.care/skincare/ca/p/innisfree/daily-uv-defense-mineral-sunscreen/for/acne-prone-skin) — Superior fit — CA$24.50 at Amazon

## Where to buy

- Sephora: CA$94.00 (https://www.sephora.com/ca/en/product/biossance-squalane-copper-peptide-rapid-plumping-serum-P479304?skuId=2536076)
Prices checked 16 Oct 2026.

## Ingredients

Water, Glycerin, Propanediol, Squalane, Sodium Hyaluronate, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Copper Tripeptide-1, Acmella Oleracea Extract, Ectoin, Tetrapeptide-30, Palmitoyl Hexapeptide-52, Copper Pca, Panthenol, Sodium Polyglutamate, Camellia Sinensis Leaf Extract, Aloe Barbadensis Flower Extract, Passiflora Incarnata Flower Extract, Melia Azadirachta Leaf Extract, Solanum Melongena Fruit Extract, Curcuma Longa Root Extract, Ocimum Basilicum Leaf Extract Flower, Coccinia Indica Fruit Extract, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Corallina Officinalis Extract, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Xanthan Gum, Phenoxyethanol, Ethylhexylglycerin, Citric Acid, Caprylyl Glycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/acne-prone-skin
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- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/acne-prone-skin (this page)
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