# BIOEFFECT EGF Power Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/bioeffect/egf-power-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [BIOEFFECT](https://lovi.care/skincare/ca/brands/bioeffect)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your combination skin, as Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1 and Kgf Barley Sh-Polypeptide-3 promote skin regeneration and elasticity, while Glycerin and Sodium Hyaluronate provide essential hydration to manage oily shine.
- While supportive for combination skin, the serum lacks specific ingredients to directly target and reduce excess oil production.
- The product is safe for your skin, with no reported irritation risks due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/bioeffect/egf-power-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/bioeffect/egf-power-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/bioeffect/egf-power-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/bioeffect/egf-power-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/bioeffect/egf-power-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/bioeffect/egf-power-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/bioeffect/egf-power-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/bioeffect/egf-power-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/bioeffect/egf-power-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Rh-Oligopeptide-1, Sodium Hyaluronate, Acetyl Glucosamine, Hordeum Vulgare Seed Extract, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Epidermal growth factor stimulates keratinocyte proliferation, migration, and differentiation markers resembling wounded epidermis, whereas keratinocyte growth factor maintains a healthy native epidermal architecture and turnover. ([Wound Repair and Regeneration, 2000](https://pubmed.ncbi.nlm.nih.gov/10886810/))
- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

This serum is highly effective for mature, dry, and aging skin, with users frequently reporting improvements in texture, firmness, and radiance. Based on limited data, the product is praised for visibly reducing fine lines and hyperpigmentation, leaving the complexion plumper and more even-toned. Some users note a tacky feel after application and that results require patience, while the high price point is a common concern.

- Liked: Improves skin texture (mostly mentioned)
- Disliked: High price point (mostly mentioned)
- Liked: Boosts skin radiance (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Liked: Deeply hydrating (sometimes noted)
- Liked: Gentle formula (sometimes noted)
- Disliked: Requires patience (sometimes noted)
- Disliked: Tacky skin feel (sometimes noted)
- Disliked: Limited care feeling (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does BIOEFFECT EGF Power Serum work for combination skin?

This serum works moderately well for your combination skin because it provides essential hydration while supporting regeneration, though other products fit this skin better by including ingredients like niacinamide, zinc PCA, or propolis to actively regulate oily shine and enhance radiance.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Wound Repair and Regeneration, 2000](https://pubmed.ncbi.nlm.nih.gov/10886810/)

### Which ingredients make this serum a good fit for combination skin?

This serum works for combination skin because Rh-oligopeptide-1 and KGF promote skin regeneration and elasticity, while glycerin and sodium hyaluronate provide essential hydration to manage oily shine. To work best for this skin type, a product of this type needs ingredients like niacinamide, propolis, or zinc PCA to regulate oiliness and enhance radiance without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Wound Repair and Regeneration, 2000](https://pubmed.ncbi.nlm.nih.gov/10886810/)

### What does EGF do for combination skin?

EGF helps support cell turnover and collagen production, which may improve firmness and keep combination skin looking smooth and even. For the best results on combination skin, this ingredient works well alongside hydrating ingredients like hyaluronic acid to balance oilier and dry areas.
Sources: [Journal of Drugs in Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30909351/), [Cell Proliferation, 2022](https://pubmed.ncbi.nlm.nih.gov/35274780/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine, after cleansing and before moisturizing, to keep things simple and safe around sun exposure. It is safe for your skin with no reported irritation risks, though a product for combination skin also needs specific ingredients to directly target and reduce excess oil production.

### Can I use this serum with retinol, and in what order?

You can use this serum in your evening routine, applying it after cleansing and toning, and before your moisturizer. When pairing it with retinol, apply your retinol first and let it absorb completely before using this treatment to help keep your skin comfortable and well-hydrated.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Wound Repair and Regeneration, 2000](https://pubmed.ncbi.nlm.nih.gov/10886810/)

### How often should I use this serum?

Use this treatment in the evening as part of your nighttime routine. This helps keep things simple and safe around sun exposure.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for your combination skin since it is safe and free of harsh ingredients, though it lacks specific ingredients to directly target and reduce excess oil production. Combination skin of this type needs lightweight hydrators and oil-balancing ingredients like niacinamide or salicylic acid to help control shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Wound Repair and Regeneration, 2000](https://pubmed.ncbi.nlm.nih.gov/10886810/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/combination-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/combination-skin) — Average fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Glycerin, Water, Sodium Citrate, Acetyl Glucosamine Nag, Isopentyldiol, Phenoxyethanol, Sodium Chloride, Sodium Hyaluronate, Citric Acid, Hordeum Vulgare Seed Extract, Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1, Kgf Barley Sh-Polypeptide-3
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/bioeffect/egf-power-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/bioeffect/egf-power-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/bioeffect/egf-power-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/bioeffect/egf-power-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/bioeffect/egf-power-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/bioeffect/egf-power-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/bioeffect/egf-power-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/bioeffect/egf-power-serum/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/bioeffect/egf-power-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/bioeffect/egf-power-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/bioeffect/egf-power-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/bioeffect/egf-power-serum/for/combination-skin