# Avène Cleanance Comedomed for oily skin

**Lovi Fit: Average fit for oily skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Avène](https://lovi.care/skincare/ca/brands/avene)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily skin; other serums fit it better.

## Why this fit

- Offers moderate exfoliation for your oily skin due to the presence of glycolic acid and salicylic acid, which help reduce blemishes and manage oiliness, though their concentrations may not fully address significant shine.
- Glycerin and dipotassium glycyrrhizate provide general hydration and soothing benefits, supporting overall skin health without directly targeting oily shine.
- The formula is safe for your oily skin, as it lacks harsh ingredients and is unlikely to cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/oily-skin): Average (this page)
- [Dry skin](https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/oily-acne-prone-skin): High

## Key ingredients

Salicylic Acid, Glycolic Acid, Zinc Gluconate, Silybum Marianum Fruit Extract, Pumpkin Seed Oil

## What the research says

- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Daily use of a deep cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% significantly reduced total lesion count by 56.3% after 84 days in 35 subjects with mild to moderate truncal acne. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36698447/))
- A dermocosmetic cream containing Punica granatum Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and Aqua Posae Filiformis significantly decreased inflammatory, non-inflammatory, and total lesion counts in subjects with mild to moderate acne compared to untreated hemi-faces after 15 days. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41487026/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical 5% benzoyl peroxide plus salicylic acid achieved the greatest lesion reduction at early 2 to 4 week time points compared to benzoyl peroxide, clindamycin, and combination benzoyl peroxide/clindamycin, while 5% benzoyl peroxide plus salicylic acid and combination benzoyl peroxide/clindamycin showed similar efficacy at 10 to 12 weeks in acne patients. ([Journal of the American Academy of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20488582/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))
- Different strains of Propionibacterium acnes modulate cutaneous innate immunity with varying pro-inflammatory potentials, with P. acnes type III showing the highest and P. avidum the weakest, and zinc gluconate down-regulates the expression of most induced immune markers. ([Experimental Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23947673/))
- Zinc gluconate induced alpha2, alpha3, alphaV, and alpha6 integrins, copper gluconate induced alpha2, alpha6, and beta1, and manganese gluconate induced most studied integrins in cultured keratinocytes. ([The British Journal of Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10215764/))
- Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37675655/))
- Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36204969/))
- Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris. ([Journal of Cutaneous Medicine and Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/37942562/))
- Topical treatment with pumpkin seed oil healed uniform wounds in rats, achieving full re-epithelialization, reappearance of skin appendages, and well-organized collagen fibers compared to untreated controls. ([Lipids in Health and Disease, 2016](https://pubmed.ncbi.nlm.nih.gov/27068642/))
- A combinational sunscreen formulation of UV filters, melatonin, and pumpkin seed oil ameliorated UV radiation-induced photoaging in adult Wistar albino rats by increasing SOD, GSH-Px, CAT, and collagen levels, while decreasing skin edema, skin thickness, and inflammatory cytokines compared to UV-exposed controls. ([European Journal of Pharmaceutical Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/30414837/))
- Topical pumpkin seed oil increased hair follicle proliferation in mice without causing liver toxicity, oxidative stress, or genotoxicity. ([Acta Histochemica, 2022](https://pubmed.ncbi.nlm.nih.gov/35447441/))

## Why other serums fit oily skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

This treatment is frequently praised for its effectiveness on oily, blemish-prone, and sensitive skin, particularly in managing blackheads and closed comedones, with many users reporting clearer skin and fewer breakouts. A significant number of users also appreciate its lightweight texture and matte finish. Some users note a strong chemical scent and a drying effect, with a few experiencing irritation or a sticky consistency.

- Liked: Reduces blemishes (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Strong chemical scent (often mentioned)
- Liked: Matte finish (sometimes noted)
- Liked: Prevents recurrence (sometimes noted)
- Disliked: Drying effect (sometimes noted)
- Disliked: Can cause irritation (rarely noted)
- Disliked: Sticky consistency (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Avene Cleanance Comedomed work for oily skin?

Avene Cleanance Comedomed offers moderate exfoliation for your oily skin using glycolic acid and salicylic acid, which help reduce blemishes and manage oiliness, though their concentrations may not fully address significant shine. Treatments that fit oily skin better need ingredients like niacinamide, zinc PCA, and ferulic acid to control sebum production and manage shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36698447/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41487026/)

### Which ingredients make this treatment a good fit for oily skin?

Glycolic acid and salicylic acid make this treatment a fit for your oily skin by offering moderate exfoliation that helps reduce blemishes and manage oiliness, while glycerin and dipotassium glycyrrhizate provide general hydration and soothing benefits. Oily skin often needs ingredients like niacinamide and ferulic acid that control sebum production and manage shine, along with a combination of soothing extracts and hydrators for comfortable daily use.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36698447/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41487026/)

### What does Salicylic Acid do for oily skin?

Salicylic acid helps oily skin by reducing excess oil and keeping pores clear. It may also improve overall skin hydration while managing breakouts.
Sources: [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682377/), [Experimental Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30972839/)

### What does Glycolic Acid do for oily skin?

Glycolic acid helps clear away dead skin and excess oil for a smooth, clean feel. It gently removes buildup from the surface, which keeps pores clear and skin looking fresh.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37894698/), [Journal of the European Academy of Dermatology and Venereology, 2011](https://pubmed.ncbi.nlm.nih.gov/21029205/)

### Where does this treatment go in a skincare routine for oily skin?

This treatment goes in the evening routine, as treatments like serums and ampoules with actives are placed there for simplicity and extra safety around sun exposure. Oily skin also needs ingredients like higher concentrations of glycolic acid and salicylic acid to fully address shine and reduce blemishes, along with soothing agents to keep skin calm.

### Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol by applying the treatment first and following with retinol, but watch for dryness since both can be strong. An oily skin routine needs ingredients that deeply control extra shine and provide stronger oil-balancing support.

### How often should I use this treatment?

Start by using this treatment once a week in the evening, and if your oily skin tolerates it well and shows good results, you can carefully use it more often. This product works for your skin, though an oily skin type needs stronger oil-controlling and shine-reducing ingredients for best results.

### Can this treatment clog pores, cause breakouts or purging for oily skin?

This treatment is unlikely to cause irritation on oily skin, but it may cause a drying effect or temporary purging as the ingredients work to clear blemishes. Oily skin often needs targeted oil-controlling ingredients and stronger blemish-fighting acids to better manage stubborn shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36698447/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41487026/)

### Is this treatment fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for oily skin

- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/oily-skin) — High fit — CA$27.99 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/oily-skin) — High fit — CA$24.44 at Amazon
- [ANUA PEACH 70% NIACINAMIDE SERUM](https://lovi.care/skincare/ca/p/anua/peach-70-niacinamide-serum/for/oily-skin) — High fit — CA$33.50 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — CA$20.96 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Proylene Glycol, Glycerin, Cetearyl Alcohol, Cetearyl Glucoside, Glyceryl Stearate, Peg-100 Stearate, Silica, Dimethicone, Bht, Caprylic Capric Triglyceride, Pumpkin Seed Oil, Sodium Hydroxide, Sodium Polyacrylate, Sodium Stearoyl Glutamate, Zinc Gluconate, Capryloyl Glycine, Citric Acid, Parfum, Disodium Edta, Sodium Benzoate, Potassium Sorbate, Glyceryl Laurate, Monolaurin, Silybum Marianum Fruit Extract, Butylene Glycol, Silymarin, Dipotassium Glycyrrhizate, Tocopherol, Glycolic Acid, Salicylic Acid, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/avene/cleanance-comedomed/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/avene/cleanance-comedomed/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/avene/cleanance-comedomed/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/avene/cleanance-comedomed/for/oily-skin
- France: https://lovi.care/skincare/fr/p/avene/cleanance-comedomed/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/avene/cleanance-comedomed/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/oily-skin (this page)
- Australia: https://lovi.care/skincare/au/p/avene/cleanance-comedomed/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/avene/cleanance-comedomed/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/avene/cleanance-comedomed/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/avene/cleanance-comedomed/for/oily-skin