# APLB Glutathione Niacinamide Facial Cream for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [APLB](https://lovi.care/skincare/ca/brands/aplb)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- Offers moderate moisturizing and treatment for your combination skin due to the presence of sodium hyaluronate and shea butter, which hydrate and enhance barrier resilience.
- The inclusion of niacinamide aids in seboregulation, while Melaleuca Alternifolia Tree Leaf Extract and Centella Asiatica Extract provide anti-inflammatory and antimicrobial benefits for your acne and blemishes.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-facial-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-facial-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-facial-cream/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-facial-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-facial-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-facial-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-facial-cream/for/oily-acne-prone-skin): High

## Key ingredients

Glutathione, Niacinamide, Centella Asiatica Extract, Sodium Hyaluronate, Shea Butter

## What the research says

- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- Topical 5% tea tree oil gel significantly improved total acne lesions and acne severity index compared to placebo in 60 patients with mild to moderate acne vulgaris, showing 3.55 times and 5.75 times greater efficacy respectively. ([Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Tea tree oil nanoemulsion containing adapalene gel demonstrated significantly greater reductions in total, inflammatory, and non-inflammatory acne lesions as well as acne severity index compared to adapalene marketed gel in 100 patients with acne vulgaris over 12 weeks. ([Archives of Dermatological Research, 2022](https://pubmed.ncbi.nlm.nih.gov/34251536/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))

## What reviewers say

Based on a very large amount of data, this lightweight, gel-like cream is highly favored by users with oily, combination, and sensitive skin for its fast absorption and soothing properties without leaving a sticky residue. Many appreciate its ability to calm redness and improve skin texture. However, users with dry skin often find it insufficiently moisturizing on its own, and brightening effects tend to be gradual or subtle.

- Liked: Affordable value (often mentioned)
- Liked: Fragrance-free (often mentioned)
- Liked: Lightweight & fast (often mentioned)
- Liked: Soothing & calming (often mentioned)
- Disliked: Not for dry skin (often mentioned)
- Disliked: No spatula (rarely noted)
- Disliked: Packaging concerns (rarely noted)
- Disliked: Slow brightening (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes APLB Glutathione Niacinamide Facial Cream a great fit for acne-prone skin?

This cream is a great fit because niacinamide helps balance oil, while tea tree leaf extract and centella asiatica extract help calm breakouts and blemishes. It also provides gentle moisture that keeps skin soft and smooth without causing irritation.
Sources: [Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this cream a good fit for acne-prone skin?

This cream is a great fit for acne-prone skin because niacinamide helps balance oil, while tea tree leaf extract and Centella asiatica extract help calm blemishes and reduce irritation. It is unlikely to cause irritation and has a very safe profile for your skin.
Sources: [Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Glutathione do for acne-prone skin?

Glutathione helps protect acne-prone skin against everyday environmental stress and oxidation. This ingredient is unlikely to clear breakouts on its own, so acne-prone skin needs a product that also targets pores, calms redness, and balances oil with ingredients like salicylic acid or niacinamide.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### Where does this cream go in a skincare routine for acne-prone skin?

This moisturizing treatment goes in the morning routine after your hydrating toner and before your sunscreen, and in the evening routine as the final moisturizing step after your treatment. It helps hydrate your skin and calm blemishes without causing irritation.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol, and applying it first helps calm the skin and reduce irritation before you put on your retinol. Using a soothing moisturizer alongside your treatment is unlikely to cause problems and may help you stick to your routine more comfortably.
Sources: [The Journal of Dermatological Treatment, 2016](https://pubmed.ncbi.nlm.nih.gov/26293170/), [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily to keep your acne-prone skin hydrated and balanced. Regular daily application helps improve moisture levels and supports skin barrier function while calming blemishes.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to clog pores or cause breakouts for acne-prone skin, as it features ingredients like niacinamide and tea tree leaf extract that help calm blemishes without harsh risks. It is a great fit for your skin, providing balanced moisture alongside anti-inflammatory benefits.
Sources: [Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can I use this cream around the eyes or on my body?

This cream is generally safe to use on the body and around the eyes, as its gentle ingredients are unlikely to cause irritation. Because the skin around the eyes is much thinner than the skin on the rest of the body, a moisturizing treatment like this helps keep those delicate areas soft and smooth without feeling heavy.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/ca/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin) — Superior fit — CA$95.99 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/ca/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — CA$24.99 at Amazon
- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/ca/p/belif/the-true-cream-aqua-bomb/for/acne-prone-skin) — High fit — CA$49.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/ca/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — CA$22.95 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — CA$41.00 at Amazon
- SPF: [innisfree Daily UV Defense Mineral Sunscreen](https://lovi.care/skincare/ca/p/innisfree/daily-uv-defense-mineral-sunscreen/for/acne-prone-skin) — Superior fit — CA$24.50 at Amazon

## Where to buy

- Amazon.ca: CA$19.98 (https://www.amazon.ca/dp/B0C2P3N623?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Centella Asiatica Extract, Glycerin, Cetyl Ethylhexanoate, Butylene Glycol, Polyglyceryl-3 Methylglucose Distearate, Stearic Acid, Sodium Polyacryloyldimethyl Taurate, Silica, Sodium Hyaluronate, Glyceryl Stearate, Beeswax, Butyrospermum Parkii Butter Shea Butter, Macadamia Ternifolia Seed Oil, Hydrogenated Polydecene, Betaine, Trehalose, Adenosine, Citric Acid, Trideceth-10, Disodium Edta, Sodium Citrate, Caprylic Capric Triglyceride, Hydrogenated Lecithin, Cholesterol, Xanthan Gum, Nelumbo Nucifera Extract, Artemisia Annua Extract, Rice Extract, Saccharomyces Ferment, Solanum Melongena Fruit Extract, Melaleuca Alternifolia Tree Leaf Extract, Hydrolyzed Collagen, Squalane, Beta-Glucan, Ascorbic Acid, Dipropylene Glycol, Hippophae Rhamnoides Fruit Extract, Madecassic Acid, Asiaticoside, Asiatic Acid, Propanediol, Hydroxyacetophenone, 1,2-Hexanediol, Ethylhexylglycerin, Dipotassium Glycyrrhizate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin