# Allies of Skin Retinal & Peptides Repair Night Cream for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Allies of Skin](https://lovi.care/skincare/ca/brands/allies-of-skin)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ca/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers excellent moisturizing and anti-aging benefits for your combination skin, as sodium hyaluronate and peptides like palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 plump and hydrate, while niacinamide and lavandula hybrida oil provide soothing effects.
- While the formula supports general skin health with hydration and soothing, it lacks targeted ingredients to directly address your acne concerns, and its seboregulation capabilities are not strong enough for combination skin.
- The product has a good safety profile with no risks of irritation due to the absence of harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/ca/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Retinaldehyde, Palmitoyl Tetrapeptide-7, Niacinamide, Glutathione, Ellagic Acid

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index. ([Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29663701/))
- Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance. ([Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12218231/))
- Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients. ([Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473959/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- A novel formulation of hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid demonstrated parity in improving pigmentation, skin tone, spot intensity, and spot size compared to standard prescription 4% hydroquinone and 0.025% tretinoin in 82 subjects, with superior tolerability. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/24305422/))
- A topical product containing 0.5% ellagic acid and 0.1% salicylic acid demonstrated comparable tolerance and efficacy in reducing hyperpigmentation and dark spots in fifty-four multiethnic subjects over 12 weeks when compared against a benchmark prescription 4% hydroquinone product. ([Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23377328/))
- Platycarya strobilacea fruit extract and its isolated ellagic acid derivatives demonstrated anti-wrinkle and antiaging potential by scavenging free radicals, inhibiting elastase, reducing MMP-1, and increasing type I collagen synthesis in human fibroblast cells, with clinical testing showing significant improvements compared to placebo. ([Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/20587350/))

## Why other moisturizers fit acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35763437/))

## What reviewers say

Based on a very large amount of data, users find this night cream to be a holy grail for sensitive skin, effectively clearing acne and smoothing fine lines without irritation. The formula is frequently described as hydrating and transformative, leading to brighter, clearer, and plumper skin by morning.

- Liked: Gentle, non-irritating (mostly mentioned)
- Liked: Clears acne (often mentioned)
- Liked: Improves texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Hydrating formula (sometimes noted)
- Disliked: Initial purging (rarely noted)
- Disliked: Slow results (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Allies of Skin Retinal & Peptides Repair Night Cream work for acne-prone skin?

Allies of Skin Retinal & Peptides Repair Night Cream is an average fit for acne-prone skin because it offers general hydration and anti-aging benefits without targeted ingredients to directly address blemishes or oil control. A product of this type needs effective ingredients that manage breakouts and balance oil production while keeping skin calm and clear.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### Which ingredients make this cream a good fit for acne-prone skin?

This cream works for acne-prone skin because niacinamide helps calm the skin and sodium hyaluronate keeps it hydrated. A product of this type needs specific ingredients to target breakouts and balance oil production.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Retinal do for acne-prone skin?

Retinal helps clear acne-prone skin by reducing blemishes, clogged pores, and redness while improving overall skin texture. Side effects are very uncommon when using this ingredient.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42572367/), [Clinical and Experimental Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10564319/)

### What does Palmitoyl Tetrapeptide-7 do for acne-prone skin?

Palmitoyl Tetrapeptide-7 is unlikely to directly clear breakouts, as it is primarily used to support firmness and help smooth fine lines. Acne-prone skin requires ingredients that manage oil and calm redness to stay clear and calm.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/)

### Where does this cream go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and toning, followed by your moisturizer. This type of product needs targeted blemish-clearing ingredients and oil-balancing agents to properly care for acne-prone skin.

### Can I use this cream with AHA, and in what order?

You can use this cream after applying an AHA, but acne-prone skin needs a treatment with targeted blemish-clearing ingredients and oil-balancing agents.

### How often should I use this cream?

This cream works well as an evening treatment, so you can apply it in your PM routine. Products of this type for acne-prone skin need targeted blemish-fighting ingredients and oil-balancing benefits to fully meet your needs.

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream works for acne-prone skin, though other products fit it better because it lacks targeted ingredients to directly address breakouts and oil control. It has a good safety profile with a low likelihood of initial purging or irritation.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes or on your body, as its formula has a very good safety profile and lacks harsh ingredients. It helps hydrate and smooth the skin in these areas while providing great tolerance.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (geraniol, limonene, and linalool).

## Alternatives for acne-prone skin

- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/ca/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin) — Superior fit — CA$95.99 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/ca/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — CA$24.99 at Amazon
- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/ca/p/belif/the-true-cream-aqua-bomb/for/acne-prone-skin) — High fit — CA$49.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/ca/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — CA$22.95 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — CA$41.00 at Amazon
- SPF: [innisfree Daily UV Defense Mineral Sunscreen](https://lovi.care/skincare/ca/p/innisfree/daily-uv-defense-mineral-sunscreen/for/acne-prone-skin) — Superior fit — CA$24.50 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Propanediol, Argania Spinosa Kernel Oil, Sodium Acrylates Copolymer, Hydrolyzed Candida Saitoana Extract, Sodium Stearoyl Glutamate, Albizia Julibrissin Bark Extract, Dimethyl Isosorbide, Galactoarabinan, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Caprooyl Tetrapeptide-3, Cassia Angustifolia Polysaccharide Seed, Sodium Hyaluronate, Oxycoccus Palustris Seed Oil Arctic Cranberry Seed Oil, Rubus Chamaemorus Berry Seed Oil Cloud Berry Seed Oil, Niacinamide, Citrus Aurantium Dulcis Callus Culture Extract, Retinal Retinaldehyde, Pterostilbene, Ellagic Acid, Phenyl T-Butylnitrone Spin Trap, Ergothioneine, Glutathione, Mirabilis Jalapa Stem Extract Flower Leaf, N-Hydroxysuccinimide, Chrysin, Glutamylamidoethyl Imidazole, Lonicera Caprifolium Flower Extract Honeysuckle Flower Extract, Lonicera Japonica Flower Extract Honeysuckle Flower Extract, Lavandula Hybrida Oil Lavendin Oil, Pentylene Glycol, Butylene Glycol, Cyclodextrin, Caprylyl Glycol, Steareth-20, Citric Acid, Xanthan Gum, Dextran, Acetyl Tributyl Citrate, Potassium Sorbate, Phenoxyethanol, Geraniol, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/acne-prone-skin
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- Canada: https://lovi.care/skincare/ca/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/acne-prone-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/allies-of-skin/retinal-and-peptides-repair-night-cream/for/acne-prone-skin