# Aestura A-Cica 365 Blemish Calming Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Aestura](https://lovi.care/skincare/ca/brands/aestura)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your combination skin is provided by niacinamide and squalane, which help regulate oil production in your oily areas and provide emollient action for drier zones.
- The serum offers significant calming and soothing benefits due to moderate concentrations of madecassoside and beta-glucan, addressing irritation effectively.
- The formula is safe for your skin, featuring soothing ingredients like Madecassoside and Beta-Glucan with no harsh components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica, Niacinamide, Madecassoside, Beta-Glucan, Squalene

## What the research says

- Squalene exhibits advantages for the skin as an emollient, antioxidant, hydrating agent, and antitumor substance based on in vitro and in vivo models. ([Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Topical application of oat beta-glucan ameliorates epidermal hyperplasia and accelerates epidermal barrier recovery by promoting keratinocyte differentiation through dectin-1-mediated ERK and p38 signaling pathways that upregulate CaSR expression. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34237364/))
- A single use of an alpha-tocopherol-enriched rinse-off product strongly increases alpha-tocopherol levels in skin barrier lipids maintained for at least 24 hours and significantly inhibits squalene photooxidation in human volunteers compared to a control product. ([Skin Pharmacology and Physiology, 2005](https://pubmed.ncbi.nlm.nih.gov/15608499/))
- The investigated actives incorporated into alkyl polyglucoside emulsifier-stabilized creams showed no skin irritation and provided increased skin hydration and reduced transepidermal water loss in 76 healthy volunteers. ([Vojnosanitetski Pregled, 2016](https://pubmed.ncbi.nlm.nih.gov/29328637/))
- Topical treatment with a mixed RetinSphere - vitamin E formulation significantly decreased lipid peroxidation levels and oxidized squalene percentage, reduced interleukin-1α concentration in lesional areas, and led to clinical improvement in 18 patients with mild comedonal acne. ([Journal of the European Academy of Dermatology and Venereology, 2014](https://pubmed.ncbi.nlm.nih.gov/24628899/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised by users with sensitive and acne-prone skin for its ability to rapidly soothe redness and repair the skin barrier without causing irritation. The lightweight, non-sticky formula is effective for calming inflammation and improving texture. However, many users find the small bottle size and high price point to be significant drawbacks.

- Disliked: Expensive for size (mostly mentioned)
- Liked: Calms redness fast (often mentioned)
- Liked: Gentle, non-irritating (often mentioned)
- Liked: Lightweight, non-sticky (often mentioned)
- Liked: Hydrating for oily (sometimes noted)
- Liked: Improves texture (sometimes noted)
- Disliked: Not enough for dry (sometimes noted)
- Disliked: Heavy for summer (rarely noted)
- Disliked: Slightly tacky (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Aestura A-Cica 365 Blemish Calming Serum a great fit for combination skin?

This serum is a great fit because niacinamide and squalane help balance oil in your oily areas while keeping drier zones soft and smooth. Ingredients like madecassoside and beta-glucan calm irritation and soothe your skin safely without any harsh components.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Which ingredients make this serum a good fit for combination skin?

Niacinamide and squalane make this serum a great fit for your combination skin because they help balance oil in your shiny spots while keeping your dry areas soft. Ingredients like madecassoside and beta-glucan further calm irritation and support your skin barrier.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### What does Centella Asiatica do for combination skin?

Centella asiatica helps calm combination skin, keeps it balanced, and supports the moisture barrier without feeling heavy. It may also reduce redness and help keep breakouts under control.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for combination skin?

This treatment serum goes in your evening routine after cleansing and toning, and before moisturizing. Putting it in the evening helps keep your routine simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to help calm irritation, followed by your retinol. This safe layering helps keep your skin comfortable while using active treatments.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This serum is a great fit for your combination skin and is designed for evening use. Using it in your evening routine keeps things simple and provides extra safety around sun exposure.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is a great fit for combination skin and is unlikely to cause breakouts or clog pores, thanks to ingredients like niacinamide and squalane that help balance oil in oily areas while softening drier zones. It is formulated with calming ingredients like madecassoside and beta-glucan and has no harsh components, making it gentle and safe for your skin.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for combination skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/combination-skin) — High fit — CA$24.44 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/combination-skin) — High fit — CA$27.99 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/ca/p/cosrx/the-vitamin-c-23-serum/for/combination-skin) — Average fit — CA$33.98 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — CA$37.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ca/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — CA$29.98 at Amazon

## Where to buy

- Sephora: CA$52.00 (https://www.sephora.com/ca/en/product/a-cica-365-soothing-redness-relief-face-serum-ph-4-5-with-centella-asiatica-hyaluronic-P520094?skuId=2929248)
Prices checked 15 Oct 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Dipropylene Glycol, Betaine, Niacinamide, 1,2-Hexanediol, Alcohol Denat, Squalene, Diethoxyethyl Succinate, Polyglyceryl-10 Stearate, Sucrose Stearate, Polymethyl Methacrylate, Polyglyceryl-10 Laurate, Phytosterols, Caprylyl Methicone, Carbomer, Hydrogenated Lecithin, Hydrogenated Phosphatidylcholine, Tromethamine, Ethylhexylglycerin, Xanthan Gum, Propanediol, Cellulose Gum, Disodium Edta, Madecassoside, Beta-Glucan, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin (this page)
- Australia: https://lovi.care/skincare/au/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin