# Aestura A-Cica 365 Blemish Calming Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Aestura](https://lovi.care/skincare/ca/brands/aestura)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- High suitability for your combination skin is provided by niacinamide and squalane, which help regulate sebum and offer emollient action respectively.
- The serum offers excellent calming and barrier-strengthening effects for irritated skin due to the presence of madecassoside and beta-glucan.
- There are no risks of irritation for your acne-prone skin due to the absence of prohibited or harsh ingredients, and the presence of soothing ingredients like Madecassoside and Beta-Glucan.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica, Niacinamide, Madecassoside, Beta-Glucan, Squalene

## What the research says

- Squalene exhibits advantages for the skin as an emollient, antioxidant, hydrating agent, and antitumor substance based on in vitro and in vivo models. ([Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Topical application of oat beta-glucan ameliorates epidermal hyperplasia and accelerates epidermal barrier recovery by promoting keratinocyte differentiation through dectin-1-mediated ERK and p38 signaling pathways that upregulate CaSR expression. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34237364/))
- A single use of an alpha-tocopherol-enriched rinse-off product strongly increases alpha-tocopherol levels in skin barrier lipids maintained for at least 24 hours and significantly inhibits squalene photooxidation in human volunteers compared to a control product. ([Skin Pharmacology and Physiology, 2005](https://pubmed.ncbi.nlm.nih.gov/15608499/))
- The investigated actives incorporated into alkyl polyglucoside emulsifier-stabilized creams showed no skin irritation and provided increased skin hydration and reduced transepidermal water loss in 76 healthy volunteers. ([Vojnosanitetski Pregled, 2016](https://pubmed.ncbi.nlm.nih.gov/29328637/))
- Topical treatment with a mixed RetinSphere - vitamin E formulation significantly decreased lipid peroxidation levels and oxidized squalene percentage, reduced interleukin-1α concentration in lesional areas, and led to clinical improvement in 18 patients with mild comedonal acne. ([Journal of the European Academy of Dermatology and Venereology, 2014](https://pubmed.ncbi.nlm.nih.gov/24628899/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised by users with sensitive and acne-prone skin for its ability to rapidly soothe redness and repair the skin barrier without causing irritation. The lightweight, non-sticky formula is effective for calming inflammation and improving texture. However, many users find the small bottle size and high price point to be significant drawbacks.

- Disliked: Expensive for size (mostly mentioned)
- Liked: Calms redness fast (often mentioned)
- Liked: Gentle, non-irritating (often mentioned)
- Liked: Lightweight, non-sticky (often mentioned)
- Liked: Hydrating for oily (sometimes noted)
- Liked: Improves texture (sometimes noted)
- Disliked: Not enough for dry (sometimes noted)
- Disliked: Heavy for summer (rarely noted)
- Disliked: Slightly tacky (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Aestura A-Cica 365 Blemish Calming Serum a great fit for acne-prone skin?

This serum is a great fit because niacinamide helps balance oil while squalane and glycerin keep skin soft, and ingredients like madecassoside and beta-glucan calm irritation and support the skin barrier. It is unlikely to cause irritation for your acne-prone skin since harsh ingredients are absent.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit for your acne-prone skin because niacinamide and squalene help regulate oil and keep your skin soft. Additionally, madecassoside and beta-glucan provide excellent calming and barrier-strengthening effects to keep irritated skin feeling calm and smooth.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### What does Centella Asiatica do for acne-prone skin?

Centella asiatica helps calm acne-prone skin by reducing redness and soothing inflammation while supporting healing. It may also help manage breakouts by addressing factors like acne blemishes and irritation.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in your evening routine, which keeps things simple and safe around sun exposure. You can apply it after cleansing and toning, and right before your moisturizer.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to help calm your skin and strengthen your skin barrier. Using soothing ingredients alongside retinol helps reduce potential irritation and keeps your skin comfortable.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### How often should I use this serum?

This serum is a great fit for your acne-prone skin and is best used in the evening routine. It is unlikely to cause irritation and helps calm your skin while keeping it balanced.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause breakouts or clog pores on acne-prone skin because it lacks harsh or prohibited ingredients, and it features soothing components like madecassoside and beta-glucan to calm irritated areas.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for acne-prone skin

- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/acne-prone-skin) — High fit — CA$24.44 at Amazon
- [SKIN1004 Madagascar Centella Asiatica Ampoule](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-asiatica-ampoule/for/acne-prone-skin) — High fit — CA$26.25 at Amazon
- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/acne-prone-skin) — High fit — CA$27.99 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/ca/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — CA$22.95 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/ca/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — CA$41.00 at Amazon
- Moisturizer: [CeraVe CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/ca/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — CA$20.96 at Amazon

## Where to buy

- Sephora: CA$52.00 (https://www.sephora.com/ca/en/product/a-cica-365-soothing-redness-relief-face-serum-ph-4-5-with-centella-asiatica-hyaluronic-P520094?skuId=2929248)
Prices checked 15 Oct 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Dipropylene Glycol, Betaine, Niacinamide, 1,2-Hexanediol, Alcohol Denat, Squalene, Diethoxyethyl Succinate, Polyglyceryl-10 Stearate, Sucrose Stearate, Polymethyl Methacrylate, Polyglyceryl-10 Laurate, Phytosterols, Caprylyl Methicone, Carbomer, Hydrogenated Lecithin, Hydrogenated Phosphatidylcholine, Tromethamine, Ethylhexylglycerin, Xanthan Gum, Propanediol, Cellulose Gum, Disodium Edta, Madecassoside, Beta-Glucan, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/aestura/a-cica-365-blemish-calming-serum/for/acne-prone-skin
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- Canada: https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/acne-prone-skin (this page)
- Australia: https://lovi.care/skincare/au/p/aestura/a-cica-365-blemish-calming-serum/for/acne-prone-skin
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