# Advanced Clinicals Vitamin C Anti Aging Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ca/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Brand: [Advanced Clinicals](https://lovi.care/skincare/ca/brands/advanced-clinicals)
Category: [Serums and treatments](https://lovi.care/skincare/ca/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate treatment for aging concerns, as aminopropyl ascorbyl phosphate and ferulic acid provide antioxidant activity and collagen stimulation beneficial for your normal skin. Ergothioneine further supports these effects, enhancing overall skin tone and radiance.
- The inclusion of aloe barbadensis leaf juice and ginkgo biloba leaf extract offers additional soothing and antioxidant benefits, complementing the primary anti-aging ingredients.
- The product is safe for your normal skin, with no identified risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ca/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ca/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/ca/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ca/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ca/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ca/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ca/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ca/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/ca/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Ascorbic Acid, Ferulic Acid, Aloe Barbadensis Leaf Juice, Glycolic Acid, Tocopheryl Acetate

## What the research says

- Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo. ([The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/40464749/))
- A triple combination of ergothioneine, collagen peptides, and sodium hyaluronate attenuated UV-induced skin damage ex vivo and improved facial skin hydration, elasticity, barrier function, and wrinkles in Chinese women. ([Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/))
- Topical application of Ginkgo biloba cream for two weeks reduced wrinkles and improved skin shape, texture, and tautness in human volunteers compared to baseline. ([Drug Development and Industrial Pharmacy, 2023](https://pubmed.ncbi.nlm.nih.gov/37074796/))
- Topical application of a 2% cream containing combined fruit extracts for 56 days significantly reduced wrinkle depth by 11.5%, length by 10.07%, and area by 29.55% in 21 female subjects compared to a placebo. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26203268/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))
- Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control. ([Journal of Cosmetic Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19146606/))
- Topical ferulic acid-containing formulations effectively reduce skin erythema, hyperpigmentation, and signs of aging in adults compared to baseline or alternative conditions. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40538529/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))

## What reviewers say

Based on a very large amount of data, users consistently report that this serum effectively brightens the complexion and fades dark spots while being gentle enough for sensitive skin. Some users with dry skin find it slightly dehydrating or sticky, and a minority experienced breakouts or saw no visible changes in deep pigmentation.

- Liked: Brightens and evens tone (mostly mentioned)
- Liked: Excellent value (mostly mentioned)
- Liked: Gentle on sensitive skin (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Sticky or tacky finish (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Drying effect (rarely noted)
- Disliked: Ineffective for some (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Advanced Clinicals Vitamin C Serum work for mature skin?

Advanced Clinicals Vitamin C Anti Aging Serum provides moderate treatment for mature skin by using vitamin C, ferulic acid, and ergothioneine to help smooth fine lines and improve overall radiance. While it is generally safe and helps boost skin tone, a treatment for this skin type needs potent antioxidants, hydrating ingredients, and skin-repairing components that effectively target wrinkles and improve skin elasticity without irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/40464749/)

### Which ingredients make this serum a good fit for mature skin?

Aminopropyl ascorbyl phosphate, ferulic acid, and ergothioneine make this serum a good fit by providing antioxidant activity and supporting collagen to help smooth and brighten mature skin. Aloe barbadensis leaf juice and ginkgo biloba leaf extract further complement these anti-aging effects by soothing the skin. To truly thrive, mature skin needs products of this type that are exceptionally safe, exceptionally effective at targeting wrinkles, and packed with high concentrations of potent antioxidants, hydrating components, and skin-repairing ingredients.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Drug Development and Industrial Pharmacy, 2023](https://pubmed.ncbi.nlm.nih.gov/37074796/)

### What does Vitamin C do for mature skin?

Vitamin C helps mature skin by smoothing out wrinkles, brightening dark spots, and boosting firmness. It works by encouraging collagen production to keep skin looking youthful and radiant.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Ferulic Acid do for mature skin?

Ferulic acid helps protect mature skin from sun damage and pollution while improving hydration, firmness, and signs of photoaging. It also helps boost the performance of other antioxidants like vitamins C and E to keep skin looking smooth and even.
Sources: [Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/35486440/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in your evening routine, applied after cleansing and before your moisturizer. Treatments with active ingredients are placed in the evening for simplicity and extra safety around sun exposure, though some may also be used in the morning or twice a day.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the retinol in your PM routine and keeping them on separate nights or spacing them out to avoid irritation. Mature skin needs ingredients like retinoids, peptides, and rich moisturizers to better target deep lines and restore firmness.

### How often should I use this serum?

Use this serum in the evening once a week to start, and if your skin feels comfortable and you see good results, you can carefully use it more often. This type of product works best for mature skin when it includes collagen-boosting antioxidants like vitamin C and ferulic acid alongside smoothing exfoliating acids.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts for mature skin, as reviewers rarely report this issue. However, a product for this skin needs nourishing hydrators and gentle smoothing ingredients to keep pores clear and skin soft.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Dr.Althea Vitamin C Boosting Serum](https://lovi.care/skincare/ca/p/dr-althea/vitamin-c-boosting-serum/for/mature-skin) — High fit — CA$27.99 at Amazon
- [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/matrixyl-10-ha/for/mature-skin) — High fit — CA$14.40 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/ca/p/skin1004/probio-cica-intensive-ampoule/for/mature-skin) — High fit — CA$24.44 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ca/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — CA$44.95 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ca/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — CA$31.98 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/ca/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — CA$103.73 at Amazon

## Where to buy

No store in Canada has a checked price for this product, so the page shows none.

## Ingredients

Water, Aminopropyl Ascorbyl Phosphate, Ferulic Acid, Ergothioneine, Aloe Barbadensis Leaf Juice, Glycolic Acid, Lactic Acid, Tocopheryl Acetate, Ginkgo Biloba Leaf Extract, Polyvinyl Alcohol, Xanthan Gum, Peg-12 Dimethicone, Maltodextrin, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Sodium Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin (this page)
- Australia: https://lovi.care/skincare/au/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/advanced-clinicals/vitamin-c-anti-aging-serum/for/mature-skin