# Zinc and hexapeptide-9

Page: https://lovi.care/skincare/ca/ingredients/zinc-and-hexapeptide-9

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Keep them apart

Apply [zinc](https://lovi.care/skincare/ca/ingredients/zinc) in the morning and [hexapeptide-9](https://lovi.care/skincare/ca/ingredients/hexapeptide-9) at night, because mixing them together makes the peptide treatment less effective. Zinc can bind to the peptide and stop it from working properly on your skin. To fix this, simply use them at different times of the day.

- [All about zinc](https://lovi.care/skincare/ca/ingredients/zinc)
- [All about hexapeptide-9](https://lovi.care/skincare/ca/ingredients/hexapeptide-9)

### [Zinc](https://lovi.care/skincare/ca/ingredients/zinc) products

- [BYOMA Clarifying Serum](https://lovi.care/skincare/ca/p/byoma/clarifying-serum/for/dry-skin) — High fit — [CA$23.00 at Shoppers Drug Mart](https://www.shoppersdrugmart.ca/byoma-clarifying-serum/p/XM41?variantCode=5060489793447)
- [Minimalist Vitamin B5 10% Moisturizer](https://lovi.care/skincare/ca/p/minimalist/vitamin-b5-10-moisturizer/for/mature-skin) — High fit — [CA$11.99 at Amazon](https://www.amazon.ca/dp/B09Q3MWP2S?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Sunday Riley Saturn Sulfur Spot Treatment Mask](https://lovi.care/skincare/ca/p/sunday-riley/saturn-sulfur-spot-treatment-mask/for/oily-acne-prone-skin) — Superior fit

### [Hexapeptide-9](https://lovi.care/skincare/ca/ingredients/hexapeptide-9) products

- [Elemis Pro-Collagen Night Cream](https://lovi.care/skincare/ca/p/elemis/pro-collagen-night-cream/for/dry-sensitive-skin) — Superior fit — [CA$131.00 at Sephora](https://www.sephora.com/ca/en/product/elemis-pro-collagen-anti-aging-night-cream-P514133?skuId=2828507)
- [Murad Cellular Hydration Repair Serum](https://lovi.care/skincare/ca/p/murad/cellular-hydration-repair-serum/for/acne-prone-skin) — High fit
- [MARY & MAY 6 Peptide Complex Serum](https://lovi.care/skincare/ca/p/mary-and-may/6-peptide-complex-serum/for/mature-skin) — High fit — [CA$28.99 at Amazon](https://www.amazon.ca/dp/B095YHYF33?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use zinc and hexapeptide-9 together?

Keep [zinc](https://lovi.care/skincare/ca/ingredients/zinc) and [hexapeptide-9](https://lovi.care/skincare/ca/ingredients/hexapeptide-9) apart because unchelated metal ions like zinc may [complex](https://lovi.care/skincare/ca/ingredients/complex) with peptides and reduce their biological activity.

### Which goes first, zinc or hexapeptide-9?

Keep zinc and hexapeptide-9 apart in your routine because combining them may reduce their biological activity.

### Are zinc and hexapeptide-9 good for sensitive skin?

Keep zinc and hexapeptide-9 apart in your routine because they may complex together and reduce biological activity. Lovi gives them an Average fit since they are not recommended for the same application.

## Research on zinc and hexapeptide-9

- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc · Journal of Controlled Release, 2025
- [Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32983333/) Zinc · The Journal of Clinical and Aesthetic Dermatology, 2020
- [Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study](https://pubmed.ncbi.nlm.nih.gov/36698447/) Zinc · Clinical, Cosmetic and Investigational Dermatology, 2023
- [Rapid and Visible Efficacy of a Dermocosmetic in Acne Patients With Fair Skin Phototypes: Results of a Randomized Split-Face Study](https://pubmed.ncbi.nlm.nih.gov/41487026/) Zinc · Journal of Cosmetic Dermatology, 2026
- [Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/40586182/) Hexapeptide-9 · Journal of Cosmetic Dermatology, 2025

## Other combinations

- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-hexapeptide-9)
- Keep them apart: [Hydroxypinacolone retinoate and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/hydroxypinacolone-retinoate-and-hexapeptide-9)
- Keep them apart: [Pro-retinol and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/pro-retinol-and-hexapeptide-9)
- Keep them apart: [Retinal and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/retinal-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/retinoid-blend-and-hexapeptide-9)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/retinol-and-hexapeptide-9)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Vitamin A and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/vitamin-a-and-hexapeptide-9)
- Work well together: [Liposome and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/liposome-and-hexapeptide-9)
- Work well together: [Microcapsule and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/microcapsule-and-hexapeptide-9)
- Depends on the strength: [Vitamin C and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-hexapeptide-9)
- Work well together: [Betaine and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/betaine-and-hexapeptide-9)
- Work well together: [Glycerin and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/glycerin-and-hexapeptide-9)
- Work well together: [Hyaluronic acid and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/hyaluronic-acid-and-hexapeptide-9)
- Depends on the strength: [Salicylic acid and zinc](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-zinc)
- Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/niacinamide-and-hexapeptide-9)
- Work well together: [Panthenol and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/panthenol-and-hexapeptide-9)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Arginine and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/arginine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and GABA](https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-gaba)
- Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/silk-amino-acids-and-hexapeptide-9)
- Work well together: [Taurine and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/taurine-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and theanine](https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide-9)
- Keep them apart: [Citric acid and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/citric-acid-and-hexapeptide-9)
- Keep them apart: [Glycolic acid and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-hexapeptide-9)
- Work well together: [Coenzyme Q10 and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/coenzyme-q10-and-hexapeptide-9)
- Work well together: [Green tea and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/green-tea-and-hexapeptide-9)
- Work well together: [Vitamin E and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/ceramide-building-complex-and-hexapeptide-9)
- Work well together: [Cholesterol and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/cholesterol-and-hexapeptide-9)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosterol and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/phytosterol-and-hexapeptide-9)
- Work well together: [Hexapeptide-9 and squalene](https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-squalene)
- Work well together: [Hexapeptide-9 and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and baking soda](https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-baking-soda)
- Keep them apart: [Bleach and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/bleach-and-hexapeptide-9)
- Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and behenyl alcohol](https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide-9 and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/polyvinyl-alcohol-and-hexapeptide-9)
- Work well together: [Niacinamide and zinc](https://lovi.care/skincare/ca/ingredients/niacinamide-and-zinc)
- Keep them apart: [Copper and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/copper-and-hexapeptide-9)
- Keep them apart: [Benzoyl peroxide and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-hexapeptide-9)
- Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-zinc)
- Keep them apart: [Bio-placenta peptides and zinc](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-zinc)
- Keep them apart: [Zinc and collagen peptide](https://lovi.care/skincare/ca/ingredients/zinc-and-collagen-peptide)
- Keep them apart: [Zinc and copper peptide](https://lovi.care/skincare/ca/ingredients/zinc-and-copper-peptide)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Magnesium and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/magnesium-and-hexapeptide-9)
- Keep them apart: [Zinc sulfate and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/zinc-sulfate-and-hexapeptide-9)
- Keep them apart: [Zinc and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/zinc-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/zinc-and-palmitoyl-tripeptide-1)
- Keep them apart: [Zinc and peptide-rich plasma](https://lovi.care/skincare/ca/ingredients/zinc-and-peptide-rich-plasma)
- Keep them apart: [Zinc and triple peptide blend](https://lovi.care/skincare/ca/ingredients/zinc-and-triple-peptide-blend)
- Work well together: [Benzoyl peroxide and zinc](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-zinc)
- Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-hexapeptide-9)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/superoxide-dismutase-and-hexapeptide-9)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/zinc-and-hexapeptide-9
- United Kingdom: https://lovi.care/skincare/uk/ingredients/zinc-and-hexapeptide-9
- Ireland: https://lovi.care/skincare/ie/ingredients/zinc-and-hexapeptide-9
- Germany: https://lovi.care/skincare/de/ingredients/zinc-and-hexapeptide-9
- France: https://lovi.care/skincare/fr/ingredients/zinc-and-hexapeptide-9
- Italy: https://lovi.care/skincare/it/ingredients/zinc-and-hexapeptide-9
- Netherlands: https://lovi.care/skincare/nl/ingredients/zinc-and-hexapeptide-9
- Spain: https://lovi.care/skincare/es/ingredients/zinc-and-hexapeptide-9
- Canada: https://lovi.care/skincare/ca/ingredients/zinc-and-hexapeptide-9 (this page)
- Australia: https://lovi.care/skincare/au/ingredients/zinc-and-hexapeptide-9
- Singapore: https://lovi.care/skincare/sg/ingredients/zinc-and-hexapeptide-9
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/zinc-and-hexapeptide-9
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/zinc-and-hexapeptide-9