# Retinol and hexapeptide

Page: https://lovi.care/skincare/ca/ingredients/retinol-and-hexapeptide

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Depends on the strength

Use them at different times of day with peptides in the morning and [retinol](https://lovi.care/skincare/ca/ingredients/retinol) at night, because combining them all at once can irritate skin. Retinol speeds up cell turnover while peptides help build [collagen](https://lovi.care/skincare/ca/ingredients/collagen), working together to smooth skin. If your skin feels sensitive, try a lower strength or wait a few minutes between applying them.

- [All about retinol](https://lovi.care/skincare/ca/ingredients/retinol)
- [All about hexapeptide](https://lovi.care/skincare/ca/ingredients/hexapeptide)

### [Retinol](https://lovi.care/skincare/ca/ingredients/retinol) products

- [CeraVe Resurfacing Retinol Serum](https://lovi.care/skincare/ca/p/cerave/resurfacing-retinol-serum/for/dark-spots) — High fit — [CA$25.98 at Amazon](https://www.amazon.ca/dp/B09NM9TFF2?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [RoC Retinol Correxion Deep Wrinkle Night Cream](https://lovi.care/skincare/ca/p/roc/retinol-correxion-deep-wrinkle-night-cream/for/dark-spots) — High fit — [CA$42.99 at Amazon](https://www.amazon.ca/dp/B0FH5M1M1S?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Paula's Choice 1% Retinol Treatment](https://lovi.care/skincare/ca/p/paula-s-choice/1-retinol-treatment/for/dark-spots) — Superior fit — [CA$70.50 at Amazon](https://www.amazon.ca/dp/B0CKWP1Z9J?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [RoC Retinol Correxion Line Smoothing Eye Cream](https://lovi.care/skincare/ca/p/roc/retinol-correxion-line-smoothing-eye-cream/for/mature-skin) — High fit — [CA$39.99 at Amazon](https://www.amazon.ca/dp/B0FH5KNQQJ?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Good Molecules Gentle Retinol Cream](https://lovi.care/skincare/ca/p/good-molecules/gentle-retinol-cream/for/mature-skin) — High fit — [CA$14.49 at Shoppers Drug Mart](https://www.shoppersdrugmart.ca/good-molecules-gentle-retinol-cream/p/BB_810019610875?variantCode=810019610875)
- [La Roche-Posay Retinol B3 Serum](https://lovi.care/skincare/ca/p/la-roche-posay/retinol-b3-serum/for/dark-spots) — Average fit — [CA$72.00 at Amazon](https://www.amazon.ca/dp/B07Z9Y4M3C?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [DRMTLGY Retinol Body Lotion](https://lovi.care/skincare/ca/p/drmtlgy/retinol-body-lotion/for/mature-skin) — Average fit
- [RoC Retinol Correxion Deep Wrinkle Serum](https://lovi.care/skincare/ca/p/roc/retinol-correxion-deep-wrinkle-serum/for/oily-skin) — Average fit — [CA$47.99 at Amazon](https://www.amazon.ca/dp/B0FSSBJZT8?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [CeraVe Skin Renewing Retinol Serum](https://lovi.care/skincare/ca/p/cerave/skin-renewing-retinol-serum/for/dark-spots) — Average fit — [CA$37.96 at Amazon](https://www.amazon.ca/dp/B0CDLV5RKP?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Olay Regenerist Retinol 24 Night Moisturizer](https://lovi.care/skincare/ca/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin) — Superior fit — [CA$35.98 at Amazon](https://www.amazon.ca/dp/B08147WH37?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [cocokind Retinol Body Cream](https://lovi.care/skincare/ca/p/cocokind/retinol-body-cream/for/mature-skin) — Average fit
- [Neutrogena Rapid Wrinkle Repair Regenerating Cream](https://lovi.care/skincare/ca/p/neutrogena/rapid-wrinkle-repair-regenerating-cream/for/mature-skin) — High fit — [CA$30.59 at Amazon](https://www.amazon.ca/dp/B07998PL5R?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)

### [Hexapeptide](https://lovi.care/skincare/ca/ingredients/hexapeptide) products

- [SkinCeuticals P-TOX](https://lovi.care/skincare/ca/p/skinceuticals/p-tox/for/mature-skin) — High fit

## Questions and answers

### Can you use retinol and hexapeptide together?

Using [retinol](https://lovi.care/skincare/ca/ingredients/retinol) and [hexapeptide](https://lovi.care/skincare/ca/ingredients/hexapeptide) together depends on the strength, as strong retinoids and peptides should be separated to avoid increased irritation by alternating usage like applying the retinoid at night and peptides in the morning. Combining them helps enhance [collagen](https://lovi.care/skincare/ca/ingredients/collagen) synthesis and reduce irritation.

### Which goes first, retinol or hexapeptide?

Using retinol and hexapeptide together depends on the strength, and you should alternate usage by applying a retinoid at night and peptides in the morning.

### Are retinol and hexapeptide good for sensitive skin?

Combining retinol and hexapeptide depends on the strength because strong retinoids may increase irritation on sensitive skin. To avoid this, you should alternate your usage by applying the retinoid at night and peptides in the morning.

## Research on retinol and hexapeptide

- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Encapsulation and controlled release of retinol from silicone particles for topical delivery](https://pubmed.ncbi.nlm.nih.gov/29604311/) Retinol · Journal of Controlled Release, 2018
- [A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen](https://pubmed.ncbi.nlm.nih.gov/20374604/) Retinol · The British Journal of Dermatology, 2010
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019
- [Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing](https://pubmed.ncbi.nlm.nih.gov/38685700/) Retinol · International Journal of Cosmetic Science, 2024

## Other combinations

- Depends on the strength: [Retinol and niacinamide](https://lovi.care/skincare/ca/ingredients/retinol-and-niacinamide)
- Keep them apart: [Retinol and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/retinol-and-isopropyl-alcohol)
- Keep them apart: [Retinol and sodium lauryl sulfate](https://lovi.care/skincare/ca/ingredients/retinol-and-sodium-lauryl-sulfate)
- Keep them apart: [Retinol and aha blend glycolic and citric acids](https://lovi.care/skincare/ca/ingredients/retinol-and-aha-blend-glycolic-and-citric-acids)
- Keep them apart: [Retinol and citric acid](https://lovi.care/skincare/ca/ingredients/retinol-and-citric-acid)
- Keep them apart: [Glycolic acid and retinol](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-retinol)
- Keep them apart: [Retinol and lactic acid](https://lovi.care/skincare/ca/ingredients/retinol-and-lactic-acid)
- Keep them apart: [Retinol and mandelic acid](https://lovi.care/skincare/ca/ingredients/retinol-and-mandelic-acid)
- Keep them apart: [Retinol and salicylic acid](https://lovi.care/skincare/ca/ingredients/retinol-and-salicylic-acid)
- Keep them apart: [Vitamin C and retinol](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-retinol)
- Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/retinol-and-acetyl-hexapeptide-3)
- Depends on the strength: [Retinol and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/retinol-and-bio-placenta-peptides)
- Depends on the strength: [Retinol and collagen peptide](https://lovi.care/skincare/ca/ingredients/retinol-and-collagen-peptide)
- Depends on the strength: [Retinol and copper peptide](https://lovi.care/skincare/ca/ingredients/retinol-and-copper-peptide)
- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ca/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-granactive-retinoid)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-pro-retinol)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-retinoid-blend)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/ca/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-vitamin-a)
- Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/retinol-and-hexapeptide-9)
- Depends on the strength: [Retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/retinol-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/retinol-and-palmitoyl-tripeptide-1)
- Depends on the strength: [Retinol and peptide-rich plasma](https://lovi.care/skincare/ca/ingredients/retinol-and-peptide-rich-plasma)
- Depends on the strength: [Retinol and triple peptide blend](https://lovi.care/skincare/ca/ingredients/retinol-and-triple-peptide-blend)
- Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-liposome)
- Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-microcapsule)
- Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-hexapeptide)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/ca/ingredients/glycerin-and-hexapeptide)
- Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/ca/ingredients/niacinamide-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/ca/ingredients/panthenol-and-hexapeptide)
- Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-hexapeptide)
- Work well together: [Retinol and bakuchiol](https://lovi.care/skincare/ca/ingredients/retinol-and-bakuchiol)
- Work well together: [Retinol and coenzyme q10](https://lovi.care/skincare/ca/ingredients/retinol-and-coenzyme-q10)
- Work well together: [Retinol and green tea](https://lovi.care/skincare/ca/ingredients/retinol-and-green-tea)
- Work well together: [Retinol and vitamin E](https://lovi.care/skincare/ca/ingredients/retinol-and-vitamin-e)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-gaba)
- Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-silk-amino-acids)
- Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-taurine)
- Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide)
- Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-citric-acid)
- Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/ca/ingredients/coenzyme-q10-and-hexapeptide)
- Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/ca/ingredients/green-tea-and-hexapeptide)
- Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-hexapeptide)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/ca/ingredients/ceramide-building-complex-and-hexapeptide)
- Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-cholesterol)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-phytosterol)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-bleach)
- Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-potassium-hydroxide)
- Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-polyvinyl-alcohol)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-copper)
- Keep them apart: [Benzoyl peroxide and retinol](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-retinol)
- Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-magnesium)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-hexapeptide)
- Work well together: [Retinol and ceramide-building complex](https://lovi.care/skincare/ca/ingredients/retinol-and-ceramide-building-complex)
- Work well together: [Retinol and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/retinol-and-tri-ceramide-complex)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/retinol-and-hexapeptide
- United Kingdom: https://lovi.care/skincare/uk/ingredients/retinol-and-hexapeptide
- Ireland: https://lovi.care/skincare/ie/ingredients/retinol-and-hexapeptide
- Germany: https://lovi.care/skincare/de/ingredients/retinol-and-hexapeptide
- France: https://lovi.care/skincare/fr/ingredients/retinol-and-hexapeptide
- Italy: https://lovi.care/skincare/it/ingredients/retinol-and-hexapeptide
- Netherlands: https://lovi.care/skincare/nl/ingredients/retinol-and-hexapeptide
- Spain: https://lovi.care/skincare/es/ingredients/retinol-and-hexapeptide
- Canada: https://lovi.care/skincare/ca/ingredients/retinol-and-hexapeptide (this page)
- Australia: https://lovi.care/skincare/au/ingredients/retinol-and-hexapeptide
- Singapore: https://lovi.care/skincare/sg/ingredients/retinol-and-hexapeptide
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/retinol-and-hexapeptide
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/retinol-and-hexapeptide