# Retinol and copper peptide Page: https://lovi.care/skincare/ca/ingredients/retinol-and-copper-peptide The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada. Depends on the strength Use them at different times of day with peptides in the morning and [retinol](https://lovi.care/skincare/ca/ingredients/retinol) at night, because combining them can cause skin irritation. Retinol speeds up cell renewal while peptides help build firm, smooth skin, but mixing them at once can be too harsh. You can try a lower strength product or wait a few minutes between applying them. - [All about retinol](https://lovi.care/skincare/ca/ingredients/retinol) - [All about copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide) ### [Retinol](https://lovi.care/skincare/ca/ingredients/retinol) products - [CeraVe Resurfacing Retinol Serum](https://lovi.care/skincare/ca/p/cerave/resurfacing-retinol-serum/for/dark-spots) — High fit — [CA$25.98 at Amazon](https://www.amazon.ca/dp/B09NM9TFF2?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [RoC Retinol Correxion Deep Wrinkle Night Cream](https://lovi.care/skincare/ca/p/roc/retinol-correxion-deep-wrinkle-night-cream/for/dark-spots) — High fit — [CA$42.99 at Amazon](https://www.amazon.ca/dp/B0FH5M1M1S?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Paula's Choice 1% Retinol Treatment](https://lovi.care/skincare/ca/p/paula-s-choice/1-retinol-treatment/for/dark-spots) — Superior fit — [CA$70.50 at Amazon](https://www.amazon.ca/dp/B0CKWP1Z9J?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [RoC Retinol Correxion Line Smoothing Eye Cream](https://lovi.care/skincare/ca/p/roc/retinol-correxion-line-smoothing-eye-cream/for/mature-skin) — High fit — [CA$39.99 at Amazon](https://www.amazon.ca/dp/B0FH5KNQQJ?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Good Molecules Gentle Retinol Cream](https://lovi.care/skincare/ca/p/good-molecules/gentle-retinol-cream/for/mature-skin) — High fit — [CA$14.49 at Shoppers Drug Mart](https://www.shoppersdrugmart.ca/good-molecules-gentle-retinol-cream/p/BB_810019610875?variantCode=810019610875) - [La Roche-Posay Retinol B3 Serum](https://lovi.care/skincare/ca/p/la-roche-posay/retinol-b3-serum/for/dark-spots) — Average fit — [CA$72.00 at Amazon](https://www.amazon.ca/dp/B07Z9Y4M3C?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [DRMTLGY Retinol Body Lotion](https://lovi.care/skincare/ca/p/drmtlgy/retinol-body-lotion/for/mature-skin) — Average fit - [RoC Retinol Correxion Deep Wrinkle Serum](https://lovi.care/skincare/ca/p/roc/retinol-correxion-deep-wrinkle-serum/for/oily-skin) — Average fit — [CA$47.99 at Amazon](https://www.amazon.ca/dp/B0FSSBJZT8?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [CeraVe Skin Renewing Retinol Serum](https://lovi.care/skincare/ca/p/cerave/skin-renewing-retinol-serum/for/dark-spots) — Average fit — [CA$37.96 at Amazon](https://www.amazon.ca/dp/B0CDLV5RKP?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Olay Regenerist Retinol 24 Night Moisturizer](https://lovi.care/skincare/ca/p/olay/regenerist-retinol-24-night-moisturizer/for/mature-skin) — Superior fit — [CA$35.98 at Amazon](https://www.amazon.ca/dp/B08147WH37?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [cocokind Retinol Body Cream](https://lovi.care/skincare/ca/p/cocokind/retinol-body-cream/for/mature-skin) — Average fit - [Neutrogena Rapid Wrinkle Repair Regenerating Cream](https://lovi.care/skincare/ca/p/neutrogena/rapid-wrinkle-repair-regenerating-cream/for/mature-skin) — High fit — [CA$30.59 at Amazon](https://www.amazon.ca/dp/B07998PL5R?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) ### [Copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide) products - [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/ca/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [CA$39.50 at Amazon](https://www.amazon.ca/dp/B0C9DXGXZ3?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Biossance Squalane + Copper Peptide Rapid Plumping Serum](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dry-skin) — Superior fit — [CA$94.00 at Sephora](https://www.sephora.com/ca/en/product/biossance-squalane-copper-peptide-rapid-plumping-serum-P479304?skuId=2536076) - [Good Molecules Super Peptide Serum](https://lovi.care/skincare/ca/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [CA$26.40 at Amazon](https://www.amazon.ca/dp/B091MTKS35?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Allies of Skin Copper Tripeptide & Ectoin Advanced Repair Serum](https://lovi.care/skincare/ca/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/oily-acne-prone-skin) — High fit - [COSRX Advanced Snail Peptide Eye Cream](https://lovi.care/skincare/ca/p/cosrx/advanced-snail-peptide-eye-cream/for/dark-spots) — High fit — [CA$48.96 at Amazon](https://www.amazon.ca/dp/B07ZRF416W?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Hero Cosmetics Rescue Balm](https://lovi.care/skincare/ca/p/hero-cosmetics/rescue-balm/for/mature-skin) — High fit — [CA$14.97 at Amazon](https://www.amazon.ca/dp/B0DN87PY6V?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Mederma PM Intensive Overnight Scar Cream](https://lovi.care/skincare/ca/p/mederma/pm-intensive-overnight-scar-cream/for/sensitive-skin) — High fit - [Perricone MD Cold Plasma Plus+](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/mature-skin) — Average fit — [CA$196.52 at Amazon](https://www.amazon.ca/dp/B0FWHBTQYK?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/ca/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit - [Peach & Lily Copper Peptide Pro Firming Serum](https://lovi.care/skincare/ca/p/peach-and-lily/copper-peptide-pro-firming-serum/for/mature-skin) — High fit - [Theramid Copper Peptide](https://lovi.care/skincare/ca/p/theramid/copper-peptide/for/oily-skin) — High fit - [SKIN1004 Zombie Pack](https://lovi.care/skincare/ca/p/skin1004/zombie-pack/for/oily-skin) — Average fit — [CA$32.99 at Amazon](https://www.amazon.ca/dp/B06XZV7ZGC?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use retinol and copper peptide together? Yes, you can use [retinol](https://lovi.care/skincare/ca/ingredients/retinol) and [copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide) together depending on the strength, and you can find both ingredients in MISSHA Time Revolution Night Repair Ampoule. Combining them enhances [collagen](https://lovi.care/skincare/ca/ingredients/collagen) synthesis, though strong retinoids should be separated or alternated to help avoid irritation. ### Which goes first, retinol or copper peptide? Whether retinol or copper peptide goes first depends on the strength of the retinoid, as strong formulas should be avoided or separated by alternating usage like applying peptides in the morning and retinol at night. For milder formulas, they may be combined in layered routines because peptides pair well with retinol to enhance collagen synthesis. ### Are retinol and copper peptide good for sensitive skin? Combining retinol and copper peptide depends on the strength because strong retinoids may increase irritation on sensitive skin, so you should alternate usage by applying retinoids at night and peptides in the morning. ## Research on retinol and copper peptide - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Encapsulation and controlled release of retinol from silicone particles for topical delivery](https://pubmed.ncbi.nlm.nih.gov/29604311/) Retinol · Journal of Controlled Release, 2018 - [A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen](https://pubmed.ncbi.nlm.nih.gov/20374604/) Retinol · The British Journal of Dermatology, 2010 - [Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin](https://pubmed.ncbi.nlm.nih.gov/16847171/) Copper peptide · Archives of Facial Plastic Surgery, 2006 - [Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing](https://pubmed.ncbi.nlm.nih.gov/38685700/) Retinol · International Journal of Cosmetic Science, 2024 - [Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu](https://pubmed.ncbi.nlm.nih.gov/42573538/) Copper peptide · Skin Research and Technology, 2026 ## Other combinations - Depends on the strength: [Retinol and niacinamide](https://lovi.care/skincare/ca/ingredients/retinol-and-niacinamide) - Keep them apart: [Retinol and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/retinol-and-isopropyl-alcohol) - Keep them apart: [Retinol and sodium lauryl sulfate](https://lovi.care/skincare/ca/ingredients/retinol-and-sodium-lauryl-sulfate) - Keep them apart: [Retinol and aha blend glycolic and citric acids](https://lovi.care/skincare/ca/ingredients/retinol-and-aha-blend-glycolic-and-citric-acids) - Keep them apart: [Retinol and citric acid](https://lovi.care/skincare/ca/ingredients/retinol-and-citric-acid) - Keep them apart: [Glycolic acid and retinol](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-retinol) - Keep them apart: [Retinol and lactic acid](https://lovi.care/skincare/ca/ingredients/retinol-and-lactic-acid) - Keep them apart: [Retinol and mandelic acid](https://lovi.care/skincare/ca/ingredients/retinol-and-mandelic-acid) - Keep them apart: [Retinol and salicylic acid](https://lovi.care/skincare/ca/ingredients/retinol-and-salicylic-acid) - Keep them apart: [Vitamin C and retinol](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-retinol) - Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/retinol-and-acetyl-hexapeptide-3) - Depends on the strength: [Retinol and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/retinol-and-bio-placenta-peptides) - Depends on the strength: [Retinol and collagen peptide](https://lovi.care/skincare/ca/ingredients/retinol-and-collagen-peptide) - Keep them apart: [Adapalene and copper peptide](https://lovi.care/skincare/ca/ingredients/adapalene-and-copper-peptide) - Keep them apart: [Granactive retinoid and copper peptide](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-copper-peptide) - Keep them apart: [Hydroxypinacolone retinoate and copper peptide](https://lovi.care/skincare/ca/ingredients/hydroxypinacolone-retinoate-and-copper-peptide) - Keep them apart: [Pro-retinol and copper peptide](https://lovi.care/skincare/ca/ingredients/pro-retinol-and-copper-peptide) - Keep them apart: [Retinal and copper peptide](https://lovi.care/skincare/ca/ingredients/retinal-and-copper-peptide) - Keep them apart: [Retinoid blend and copper peptide](https://lovi.care/skincare/ca/ingredients/retinoid-blend-and-copper-peptide) - Keep them apart: [Tretinoin and copper peptide](https://lovi.care/skincare/ca/ingredients/tretinoin-and-copper-peptide) - Keep them apart: [Vitamin A and copper peptide](https://lovi.care/skincare/ca/ingredients/vitamin-a-and-copper-peptide) - Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/ca/ingredients/retinol-and-hexapeptide) - Depends on the strength: [Retinol and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/retinol-and-hexapeptide-9) - Depends on the strength: [Retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/retinol-and-palmitoyl-pentapeptide-4) - Depends on the strength: [Retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/retinol-and-palmitoyl-tripeptide-1) - Depends on the strength: [Retinol and peptide-rich plasma](https://lovi.care/skincare/ca/ingredients/retinol-and-peptide-rich-plasma) - Depends on the strength: [Retinol and triple peptide blend](https://lovi.care/skincare/ca/ingredients/retinol-and-triple-peptide-blend) - Work well together: [Liposome and copper peptide](https://lovi.care/skincare/ca/ingredients/liposome-and-copper-peptide) - Work well together: [Microcapsule and copper peptide](https://lovi.care/skincare/ca/ingredients/microcapsule-and-copper-peptide) - Keep them apart: [Vitamin C and copper peptide](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-copper-peptide) - Work well together: [Betaine and copper peptide](https://lovi.care/skincare/ca/ingredients/betaine-and-copper-peptide) - Work well together: [Glycerin and copper peptide](https://lovi.care/skincare/ca/ingredients/glycerin-and-copper-peptide) - Work well together: [Hyaluronic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/hyaluronic-acid-and-copper-peptide) - Depends on the strength: [Niacinamide and copper peptide](https://lovi.care/skincare/ca/ingredients/niacinamide-and-copper-peptide) - Work well together: [Panthenol and copper peptide](https://lovi.care/skincare/ca/ingredients/panthenol-and-copper-peptide) - Work well together: [Bakuchiol and copper peptide](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-copper-peptide) - Work well together: [Retinol and bakuchiol](https://lovi.care/skincare/ca/ingredients/retinol-and-bakuchiol) - Work well together: [Retinol and coenzyme q10](https://lovi.care/skincare/ca/ingredients/retinol-and-coenzyme-q10) - Work well together: [Retinol and green tea](https://lovi.care/skincare/ca/ingredients/retinol-and-green-tea) - Work well together: [Retinol and vitamin E](https://lovi.care/skincare/ca/ingredients/retinol-and-vitamin-e) - Work well together: [Arginine and copper peptide](https://lovi.care/skincare/ca/ingredients/arginine-and-copper-peptide) - Work well together: [Copper peptide and GABA](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-gaba) - Work well together: [Silk amino acids and copper peptide](https://lovi.care/skincare/ca/ingredients/silk-amino-acids-and-copper-peptide) - Work well together: [Taurine and copper peptide](https://lovi.care/skincare/ca/ingredients/taurine-and-copper-peptide) - Work well together: [Copper peptide and theanine](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and copper peptide](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-copper-peptide) - Keep them apart: [Copper peptide and citric acid](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-citric-acid) - Keep them apart: [Glycolic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-copper-peptide) - Keep them apart: [Lactic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-copper-peptide) - Keep them apart: [Mandelic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-copper-peptide) - Work well together: [Coenzyme Q10 and copper peptide](https://lovi.care/skincare/ca/ingredients/coenzyme-q10-and-copper-peptide) - Work well together: [Green tea and copper peptide](https://lovi.care/skincare/ca/ingredients/green-tea-and-copper-peptide) - Work well together: [Vitamin E and copper peptide](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-copper-peptide) - Work well together: [Copper peptide and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-beta-sitosterol) - Work well together: [Ceramide-building complex and copper peptide](https://lovi.care/skincare/ca/ingredients/ceramide-building-complex-and-copper-peptide) - Work well together: [Cholesterol and copper peptide](https://lovi.care/skincare/ca/ingredients/cholesterol-and-copper-peptide) - Work well together: [Phytosphingosine and copper peptide](https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-copper-peptide) - Work well together: [Phytosterol and copper peptide](https://lovi.care/skincare/ca/ingredients/phytosterol-and-copper-peptide) - Work well together: [Copper peptide and squalene](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-squalene) - Work well together: [Copper peptide and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-copper-peptide) - Keep them apart: [Copper peptide and baking soda](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-baking-soda) - Keep them apart: [Bleach and copper peptide](https://lovi.care/skincare/ca/ingredients/bleach-and-copper-peptide) - Keep them apart: [Potassium hydroxide and copper peptide](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-copper-peptide) - Keep them apart: [Copper peptide and behenyl alcohol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-behenyl-alcohol) - Keep them apart: [Copper peptide and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-isopropyl-alcohol) - Keep them apart: [Polyvinyl alcohol and copper peptide](https://lovi.care/skincare/ca/ingredients/polyvinyl-alcohol-and-copper-peptide) - Keep them apart: [Copper and copper peptide](https://lovi.care/skincare/ca/ingredients/copper-and-copper-peptide) - Keep them apart: [Benzoyl peroxide and retinol](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-retinol) - Keep them apart: [Benzoyl peroxide and copper peptide](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-copper-peptide) - Keep them apart: [Magnesium and copper peptide](https://lovi.care/skincare/ca/ingredients/magnesium-and-copper-peptide) - Keep them apart: [Zinc and copper peptide](https://lovi.care/skincare/ca/ingredients/zinc-and-copper-peptide) - Keep them apart: [Zinc sulfate and copper peptide](https://lovi.care/skincare/ca/ingredients/zinc-sulfate-and-copper-peptide) - Work well together: [Retinol and ceramide-building complex](https://lovi.care/skincare/ca/ingredients/retinol-and-ceramide-building-complex) - Work well together: [Retinol and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/retinol-and-tri-ceramide-complex) - Keep them apart: [Azelaic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-copper-peptide) - Keep them apart: [Copper peptide and protease](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-protease) - Keep them apart: [Superoxide dismutase and copper peptide](https://lovi.care/skincare/ca/ingredients/superoxide-dismutase-and-copper-peptide) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/retinol-and-copper-peptide - United Kingdom: https://lovi.care/skincare/uk/ingredients/retinol-and-copper-peptide - Ireland: https://lovi.care/skincare/ie/ingredients/retinol-and-copper-peptide - Germany: https://lovi.care/skincare/de/ingredients/retinol-and-copper-peptide - France: https://lovi.care/skincare/fr/ingredients/retinol-and-copper-peptide - Italy: https://lovi.care/skincare/it/ingredients/retinol-and-copper-peptide - Netherlands: https://lovi.care/skincare/nl/ingredients/retinol-and-copper-peptide - Spain: https://lovi.care/skincare/es/ingredients/retinol-and-copper-peptide - Canada: https://lovi.care/skincare/ca/ingredients/retinol-and-copper-peptide (this page) - Australia: https://lovi.care/skincare/au/ingredients/retinol-and-copper-peptide - Singapore: https://lovi.care/skincare/sg/ingredients/retinol-and-copper-peptide - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/retinol-and-copper-peptide - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/retinol-and-copper-peptide