# Phytosphingosine and copper peptide

Page: https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-copper-peptide

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Work well together

Use them together in the same routine, applying the [copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide) first and the [phytosphingosine](https://lovi.care/skincare/ca/ingredients/phytosphingosine) right after, because lipids help peptides absorb better. Copper peptide helps firm your skin while phytosphingosine strengthens your moisture barrier, making them a great team for healthier skin. If your skin feels sensitive, you can apply them on alternate nights or wait a few minutes between steps.

- [All about phytosphingosine](https://lovi.care/skincare/ca/ingredients/phytosphingosine)
- [All about copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide)

### [Phytosphingosine](https://lovi.care/skincare/ca/ingredients/phytosphingosine) products

- [CeraVe Hydrating Facial Cleanser](https://lovi.care/skincare/ca/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — [CA$20.19 at Amazon](https://www.amazon.ca/dp/B0843XGN3H?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/ca/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — [CA$20.96 at Amazon](https://www.amazon.ca/dp/B083GG19DS?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Aestura Atobarrier 365 Cream](https://lovi.care/skincare/ca/p/aestura/atobarrier-365-cream/for/dry-skin) — High fit — [CA$39.99 at Amazon](https://www.amazon.ca/dp/B09YDCCJBJ?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Cetaphil Ceramide Serum](https://lovi.care/skincare/ca/p/cetaphil/ceramide-serum/for/acne-prone-skin) — Superior fit — [CA$24.53 at Amazon](https://www.amazon.ca/dp/B0DWFZ4DBV?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Bioderma Atoderm Intensive Eye](https://lovi.care/skincare/ca/p/bioderma/atoderm-intensive-eye/for/acne-prone-skin) — High fit — [CA$33.99 at Amazon](https://www.amazon.ca/dp/B08562FW67?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Obagi Rebalance Skin Barrier Recovery Cream](https://lovi.care/skincare/ca/p/obagi/rebalance-skin-barrier-recovery-cream/for/dry-sensitive-skin) — High fit
- [Elizabeth Arden Advanced Ceramide Capsules Daily Youth Restoring Serum](https://lovi.care/skincare/ca/p/elizabeth-arden/advanced-ceramide-capsules-daily-youth-restoring-serum/for/oily-skin) — High fit — [CA$124.00 at Amazon](https://www.amazon.ca/dp/B0H4WF9SG1?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)

### [Copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide) products

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/ca/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [CA$39.50 at Amazon](https://www.amazon.ca/dp/B0C9DXGXZ3?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Biossance Squalane + Copper Peptide Rapid Plumping Serum](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dry-skin) — Superior fit — [CA$94.00 at Sephora](https://www.sephora.com/ca/en/product/biossance-squalane-copper-peptide-rapid-plumping-serum-P479304?skuId=2536076)
- [Good Molecules Super Peptide Serum](https://lovi.care/skincare/ca/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [CA$26.40 at Amazon](https://www.amazon.ca/dp/B091MTKS35?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Allies of Skin Copper Tripeptide & Ectoin Advanced Repair Serum](https://lovi.care/skincare/ca/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/oily-acne-prone-skin) — High fit
- [COSRX Advanced Snail Peptide Eye Cream](https://lovi.care/skincare/ca/p/cosrx/advanced-snail-peptide-eye-cream/for/dark-spots) — High fit — [CA$48.96 at Amazon](https://www.amazon.ca/dp/B07ZRF416W?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Hero Cosmetics Rescue Balm](https://lovi.care/skincare/ca/p/hero-cosmetics/rescue-balm/for/mature-skin) — High fit — [CA$14.97 at Amazon](https://www.amazon.ca/dp/B0DN87PY6V?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Mederma PM Intensive Overnight Scar Cream](https://lovi.care/skincare/ca/p/mederma/pm-intensive-overnight-scar-cream/for/sensitive-skin) — High fit
- [Perricone MD Cold Plasma Plus+](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/mature-skin) — Average fit — [CA$196.52 at Amazon](https://www.amazon.ca/dp/B0FWHBTQYK?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/ca/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit
- [MISSHA Time Revolution Night Repair Ampoule](https://lovi.care/skincare/ca/p/missha/time-revolution-night-repair-ampoule/for/dark-spots) — High fit
- [Peach & Lily Copper Peptide Pro Firming Serum](https://lovi.care/skincare/ca/p/peach-and-lily/copper-peptide-pro-firming-serum/for/mature-skin) — High fit
- [Theramid Copper Peptide](https://lovi.care/skincare/ca/p/theramid/copper-peptide/for/oily-skin) — High fit

## Questions and answers

### Can you use phytosphingosine and copper peptide together?

Yes, you can use [phytosphingosine](https://lovi.care/skincare/ca/ingredients/phytosphingosine) and [copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide) together because phytosphingosine is a lipid component that pairs well with peptides to improve absorption and reinforce skin structure.

[Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/)

### Which goes first, phytosphingosine or copper peptide?

Phytosphingosine and copper peptide work well together to enhance barrier repair and support skin structure, and you can apply either ingredient first depending on your product textures.

### Are phytosphingosine and copper peptide good for sensitive skin?

Yes, phytosphingosine and copper peptide work well together to enhance barrier support and repair. Combining them helps improve skin structure and moisture for dry, mature, or barrier-impaired skin types.

[Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/) [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/)

## Research on phytosphingosine and copper peptide

- [Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/18489348/) Phytosphingosine · International Journal of Cosmetic Science, 2007
- [Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids](https://pubmed.ncbi.nlm.nih.gov/12482041/) Phytosphingosine · Journal of the European Academy of Dermatology and Venereology, 2002
- [Salicyloyl-phytosphingosine: a novel agent for the repair of photoaged skin](https://pubmed.ncbi.nlm.nih.gov/18489360/) Phytosphingosine · International Journal of Cosmetic Science, 2007
- [Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin](https://pubmed.ncbi.nlm.nih.gov/16847171/) Copper peptide · Archives of Facial Plastic Surgery, 2006
- [Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu](https://pubmed.ncbi.nlm.nih.gov/42573538/) Copper peptide · Skin Research and Technology, 2026

## Other combinations

- Keep them apart: [Adapalene and copper peptide](https://lovi.care/skincare/ca/ingredients/adapalene-and-copper-peptide)
- Keep them apart: [Granactive retinoid and copper peptide](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-copper-peptide)
- Keep them apart: [Hydroxypinacolone retinoate and copper peptide](https://lovi.care/skincare/ca/ingredients/hydroxypinacolone-retinoate-and-copper-peptide)
- Keep them apart: [Pro-retinol and copper peptide](https://lovi.care/skincare/ca/ingredients/pro-retinol-and-copper-peptide)
- Keep them apart: [Retinal and copper peptide](https://lovi.care/skincare/ca/ingredients/retinal-and-copper-peptide)
- Keep them apart: [Retinoid blend and copper peptide](https://lovi.care/skincare/ca/ingredients/retinoid-blend-and-copper-peptide)
- Depends on the strength: [Retinol and copper peptide](https://lovi.care/skincare/ca/ingredients/retinol-and-copper-peptide)
- Keep them apart: [Tretinoin and copper peptide](https://lovi.care/skincare/ca/ingredients/tretinoin-and-copper-peptide)
- Keep them apart: [Vitamin A and copper peptide](https://lovi.care/skincare/ca/ingredients/vitamin-a-and-copper-peptide)
- Work well together: [Liposome and copper peptide](https://lovi.care/skincare/ca/ingredients/liposome-and-copper-peptide)
- Work well together: [Microcapsule and copper peptide](https://lovi.care/skincare/ca/ingredients/microcapsule-and-copper-peptide)
- Keep them apart: [Vitamin C and copper peptide](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-copper-peptide)
- Work well together: [Betaine and copper peptide](https://lovi.care/skincare/ca/ingredients/betaine-and-copper-peptide)
- Work well together: [Glycerin and copper peptide](https://lovi.care/skincare/ca/ingredients/glycerin-and-copper-peptide)
- Work well together: [Hyaluronic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/hyaluronic-acid-and-copper-peptide)
- Depends on the strength: [Niacinamide and copper peptide](https://lovi.care/skincare/ca/ingredients/niacinamide-and-copper-peptide)
- Work well together: [Panthenol and copper peptide](https://lovi.care/skincare/ca/ingredients/panthenol-and-copper-peptide)
- Work well together: [Bakuchiol and copper peptide](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-copper-peptide)
- Work well together: [Arginine and copper peptide](https://lovi.care/skincare/ca/ingredients/arginine-and-copper-peptide)
- Work well together: [Copper peptide and GABA](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-gaba)
- Work well together: [Silk amino acids and copper peptide](https://lovi.care/skincare/ca/ingredients/silk-amino-acids-and-copper-peptide)
- Work well together: [Taurine and copper peptide](https://lovi.care/skincare/ca/ingredients/taurine-and-copper-peptide)
- Work well together: [Copper peptide and theanine](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and copper peptide](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-copper-peptide)
- Keep them apart: [Copper peptide and citric acid](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-citric-acid)
- Keep them apart: [Glycolic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-copper-peptide)
- Keep them apart: [Lactic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-copper-peptide)
- Keep them apart: [Mandelic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-copper-peptide)
- Work well together: [Coenzyme Q10 and copper peptide](https://lovi.care/skincare/ca/ingredients/coenzyme-q10-and-copper-peptide)
- Work well together: [Green tea and copper peptide](https://lovi.care/skincare/ca/ingredients/green-tea-and-copper-peptide)
- Work well together: [Vitamin E and copper peptide](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-copper-peptide)
- Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-phytosphingosine)
- Work well together: [Bio-placenta peptides and phytosphingosine](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-phytosphingosine)
- Work well together: [Collagen peptide and phytosphingosine](https://lovi.care/skincare/ca/ingredients/collagen-peptide-and-phytosphingosine)
- Work well together: [Copper peptide and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and copper peptide](https://lovi.care/skincare/ca/ingredients/ceramide-building-complex-and-copper-peptide)
- Work well together: [Cholesterol and copper peptide](https://lovi.care/skincare/ca/ingredients/cholesterol-and-copper-peptide)
- Work well together: [Phytosterol and copper peptide](https://lovi.care/skincare/ca/ingredients/phytosterol-and-copper-peptide)
- Work well together: [Copper peptide and squalene](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-squalene)
- Work well together: [Copper peptide and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-tri-ceramide-complex)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Phytosphingosine and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-hexapeptide-9)
- Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosphingosine and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1)
- Work well together: [Phytosphingosine and peptide-rich plasma](https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-peptide-rich-plasma)
- Work well together: [Phytosphingosine and triple peptide blend](https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-triple-peptide-blend)
- Keep them apart: [Salicylic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-copper-peptide)
- Keep them apart: [Copper peptide and baking soda](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-baking-soda)
- Keep them apart: [Bleach and copper peptide](https://lovi.care/skincare/ca/ingredients/bleach-and-copper-peptide)
- Keep them apart: [Potassium hydroxide and copper peptide](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-copper-peptide)
- Keep them apart: [Copper peptide and behenyl alcohol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-behenyl-alcohol)
- Keep them apart: [Copper peptide and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and copper peptide](https://lovi.care/skincare/ca/ingredients/polyvinyl-alcohol-and-copper-peptide)
- Keep them apart: [Copper and copper peptide](https://lovi.care/skincare/ca/ingredients/copper-and-copper-peptide)
- Keep them apart: [Benzoyl peroxide and copper peptide](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-copper-peptide)
- Keep them apart: [Magnesium and copper peptide](https://lovi.care/skincare/ca/ingredients/magnesium-and-copper-peptide)
- Keep them apart: [Zinc and copper peptide](https://lovi.care/skincare/ca/ingredients/zinc-and-copper-peptide)
- Keep them apart: [Zinc sulfate and copper peptide](https://lovi.care/skincare/ca/ingredients/zinc-sulfate-and-copper-peptide)
- Keep them apart: [Azelaic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-copper-peptide)
- Keep them apart: [Copper peptide and protease](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-protease)
- Keep them apart: [Superoxide dismutase and copper peptide](https://lovi.care/skincare/ca/ingredients/superoxide-dismutase-and-copper-peptide)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/phytosphingosine-and-copper-peptide
- United Kingdom: https://lovi.care/skincare/uk/ingredients/phytosphingosine-and-copper-peptide
- Ireland: https://lovi.care/skincare/ie/ingredients/phytosphingosine-and-copper-peptide
- Germany: https://lovi.care/skincare/de/ingredients/phytosphingosine-and-copper-peptide
- France: https://lovi.care/skincare/fr/ingredients/phytosphingosine-and-copper-peptide
- Italy: https://lovi.care/skincare/it/ingredients/phytosphingosine-and-copper-peptide
- Netherlands: https://lovi.care/skincare/nl/ingredients/phytosphingosine-and-copper-peptide
- Spain: https://lovi.care/skincare/es/ingredients/phytosphingosine-and-copper-peptide
- Canada: https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-copper-peptide (this page)
- Australia: https://lovi.care/skincare/au/ingredients/phytosphingosine-and-copper-peptide
- Singapore: https://lovi.care/skincare/sg/ingredients/phytosphingosine-and-copper-peptide
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/phytosphingosine-and-copper-peptide
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/phytosphingosine-and-copper-peptide