# Lactic acid and gluconolactone

Page: https://lovi.care/skincare/ca/ingredients/lactic-acid-and-gluconolactone

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Work well together

Use them together at night by applying [lactic acid](https://lovi.care/skincare/ca/ingredients/lactic-acid) first and [gluconolactone](https://lovi.care/skincare/ca/ingredients/gluconolactone) second, because the gluconolactone calms and hydrates skin. Lactic acid smooths the skin, while gluconolactone adds moisture and keeps irritation away. If it feels too strong, try a lower strength or wait a few minutes between steps.

[The use of polyhydroxy acids (PHAs) in photoaged skin](https://pubmed.ncbi.nlm.nih.gov/15002656/) [A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen](https://pubmed.ncbi.nlm.nih.gov/15002657/)

- [All about lactic acid](https://lovi.care/skincare/ca/ingredients/lactic-acid)
- [All about gluconolactone](https://lovi.care/skincare/ca/ingredients/gluconolactone)

### [Lactic acid](https://lovi.care/skincare/ca/ingredients/lactic-acid) products

- [Medicube Zero Pore Pad](https://lovi.care/skincare/ca/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [CA$33.99 at Amazon](https://www.amazon.ca/dp/B0CVRCR6VF?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [First Aid Beauty KP Bump Eraser Body Scrub](https://lovi.care/skincare/ca/p/first-aid-beauty/kp-bump-eraser-body-scrub/for/dark-spots) — Average fit — [CA$46.00 at Amazon](https://www.amazon.ca/dp/B0GSX4BHQ2?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [EltaMD UV Clear Broad-Spectrum SPF 46](https://lovi.care/skincare/ca/p/eltamd/uv-clear-broad-spectrum-spf-46/for/oily-acne-prone-skin) — Superior fit
- [First Aid Beauty Facial Radiance Pads](https://lovi.care/skincare/ca/p/first-aid-beauty/facial-radiance-pads/for/sensitive-skin) — Superior fit — [CA$33.00 at Amazon](https://www.amazon.ca/dp/B0G2Z2VYW2?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [CeraVe SA Lotion for Rough & Bumpy Skin](https://lovi.care/skincare/ca/p/cerave/sa-lotion-for-rough-and-bumpy-skin/for/oily-skin) — Average fit — [CA$21.26 at Amazon](https://www.amazon.ca/dp/B08PR6N8HB?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [CeraVe Renewing SA Cream](https://lovi.care/skincare/ca/p/cerave/renewing-sa-cream/for/oily-acne-prone-skin) — High fit
- [The Ordinary Alpha Arbutin 2% + HA](https://lovi.care/skincare/ca/p/the-ordinary/alpha-arbutin-2-ha/for/dark-spots) — Superior fit — [CA$14.90 at Amazon](https://www.amazon.ca/dp/B06XCZFCFZ?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [The Ordinary Retinal 0.2% Emulsion](https://lovi.care/skincare/ca/p/the-ordinary/retinal-0-2-emulsion/for/oily-acne-prone-skin) — High fit — [CA$22.70 at Sephora](https://www.sephora.com/ca/en/product/the-ordinary-retinal-0-2-emulsion-serum-P510514?skuId=2735157)
- [Kate Somerville ExfoliKate Intensive Exfoliating Treatment](https://lovi.care/skincare/ca/p/kate-somerville/exfolikate-intensive-exfoliating-treatment/for/mature-skin) — Superior fit — [CA$38.00 at Sephora](https://www.sephora.com/ca/en/product/exfolikate-intensive-exfoliating-treatment-P232915?skuId=1201748)
- [Dr. Dennis Gross Alpha Beta Universal Daily Peel](https://lovi.care/skincare/ca/p/dr-dennis-gross/alpha-beta-universal-daily-peel/for/acne-prone-skin) — Superior fit — [CA$124.00 at Amazon](https://www.amazon.ca/dp/B0BM9PQGCS?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [The Ordinary Lactic Acid 5% + HA](https://lovi.care/skincare/ca/p/the-ordinary/lactic-acid-5-ha/for/dry-skin) — Superior fit — [CA$10.70 at Amazon](https://www.amazon.ca/dp/B01NA0F3FB?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Good Molecules Overnight Exfoliating Treatment](https://lovi.care/skincare/ca/p/good-molecules/overnight-exfoliating-treatment/for/oily-skin) — Superior fit

### [Gluconolactone](https://lovi.care/skincare/ca/ingredients/gluconolactone) products

- [CeraVe Blemish Control Cleanser](https://lovi.care/skincare/ca/p/cerave/blemish-control-cleanser/for/oily-acne-prone-skin) — Superior fit — [CA$27.47 at Amazon](https://www.amazon.ca/dp/B0CT6BCNMS?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [SKIN1004 Madagascar Centella Toning Toner](https://lovi.care/skincare/ca/p/skin1004/madagascar-centella-toning-toner/for/combination-skin) — Superior fit — [CA$28.00 at Amazon](https://www.amazon.ca/dp/B07SSRPD2K?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [BYOMA Clarifying Serum](https://lovi.care/skincare/ca/p/byoma/clarifying-serum/for/dry-skin) — High fit — [CA$23.00 at Shoppers Drug Mart](https://www.shoppersdrugmart.ca/byoma-clarifying-serum/p/XM41?variantCode=5060489793447)
- [The INKEY List PHA Toner](https://lovi.care/skincare/ca/p/the-inkey-list/pha-toner/for/acne-prone-skin) — Superior fit
- [Kiehl's Hydro-Plumping Serum Concentrate](https://lovi.care/skincare/ca/p/kiehl-s/hydro-plumping-serum-concentrate/for/dry-skin) — Superior fit — [CA$87.00 at Amazon](https://www.amazon.ca/dp/B09DGCK54J?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [StriVectin Daily Reveal Exfoliating Pads](https://lovi.care/skincare/ca/p/strivectin/daily-reveal-exfoliating-pads/for/oily-skin) — Average fit — [CA$49.00 at Amazon](https://www.amazon.ca/dp/B089TPYFX3?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Hero Cosmetics Pore Release Blackhead Clearing Solution](https://lovi.care/skincare/ca/p/hero-cosmetics/pore-release-blackhead-clearing-solution/for/combination-skin) — Superior fit
- [Some By Mi AHA-BHA-PHA 30 Days Miracle Acne Clear Foam](https://lovi.care/skincare/ca/p/some-by-mi/aha-bha-pha-30-days-miracle-acne-clear-foam/for/oily-acne-prone-skin) — High fit
- [OLEHENRIKSEN Truth Juice Daily Cleanser](https://lovi.care/skincare/ca/p/olehenriksen/truth-juice-daily-cleanser/for/oily-acne-prone-skin) — High fit
- [Face Reality sal-C toner](https://lovi.care/skincare/ca/p/face-reality/sal-c-toner/for/oily-acne-prone-skin) — High fit
- [Neutrogena Bright Boost Gel Cream](https://lovi.care/skincare/ca/p/neutrogena/bright-boost-gel-cream/for/acne-prone-skin) — High fit
- [SVR Sebiaclear Serum](https://lovi.care/skincare/ca/p/svr/sebiaclear-serum/for/combination-skin) — Superior fit — [CA$46.00 at Shoppers Drug Mart](https://www.shoppersdrugmart.ca/svr-sebiaclear-serum-30ml/p/BB_3662361000364?variantCode=3662361000364)

## Questions and answers

### Can you use lactic acid and gluconolactone together?

Yes, you can use [lactic acid](https://lovi.care/skincare/ca/ingredients/lactic-acid) and [gluconolactone](https://lovi.care/skincare/ca/ingredients/gluconolactone) together because they work well to provide gentle exfoliation and antioxidant protection with less irritation potential. You can find both ingredients in products like RNW Der. Clear AHA [BHA](https://lovi.care/skincare/ca/ingredients/salicylic-acid) PHA Peeling Mask, Biologique Recherche Lotion P50V, Farmacy Brighten Up 3% TXA, and EADEM Cashmere Peel.

## Research on lactic acid and gluconolactone

- [Lactate triggers KAT8-mediated LTBP1 lactylation at lysine 752 to promote skin rejuvenation by inducing collagen synthesis in fibroblasts](https://pubmed.ncbi.nlm.nih.gov/39102921/) Lactic acid · International Journal of Biological Macromolecules, 2024
- [Poly-L-Lactic acid increases collagen gene expression and synthesis in cultured dermal fibroblast (Hs68) through the TGF-β/Smad pathway](https://pubmed.ncbi.nlm.nih.gov/36575891/) Lactic acid · Journal of Cosmetic Dermatology, 2023
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Do urea/ammonium lactate combinations achieve better skin protection and hydration than either component alone?](https://pubmed.ncbi.nlm.nih.gov/11803256/) Lactic acid · Skin Pharmacology and Applied Skin Physiology, 2002
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023

## Other combinations

- Keep them apart: [Benzoyl peroxide and lactic acid](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-lactic-acid)
- Keep them apart: [Retinol and lactic acid](https://lovi.care/skincare/ca/ingredients/retinol-and-lactic-acid)
- Depends on the strength: [Niacinamide and lactic acid](https://lovi.care/skincare/ca/ingredients/niacinamide-and-lactic-acid)
- Work well together: [Lactic acid and sodium lactate](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-sodium-lactate)
- Work well together: [Lactic acid and tromethamine](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-tromethamine)
- Depends on the strength: [Niacinamide and gluconolactone](https://lovi.care/skincare/ca/ingredients/niacinamide-and-gluconolactone)
- Work well together: [Gluconolactone and hyaluronic acid](https://lovi.care/skincare/ca/ingredients/gluconolactone-and-hyaluronic-acid)
- Work well together: [Lactic acid and betaine](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-betaine)
- Work well together: [Glycerin and lactic acid](https://lovi.care/skincare/ca/ingredients/glycerin-and-lactic-acid)
- Depends on the strength: [Lactic acid and hyaluronic acid](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-hyaluronic-acid)
- Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Bio-placenta peptides and lactic acid](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-lactic-acid)
- Keep them apart: [Carnosine and lactic acid](https://lovi.care/skincare/ca/ingredients/carnosine-and-lactic-acid)
- Keep them apart: [Lactic acid and collagen peptide](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-collagen-peptide)
- Keep them apart: [Lactic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-copper-peptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Lactic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Lactic acid and peptide-rich plasma](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-peptide-rich-plasma)
- Keep them apart: [Lactic acid and triple peptide blend](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-triple-peptide-blend)
- Keep them apart: [Adapalene and lactic acid](https://lovi.care/skincare/ca/ingredients/adapalene-and-lactic-acid)
- Keep them apart: [Lactic acid and granactive retinoid](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-granactive-retinoid)
- Keep them apart: [Lactic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and lactic acid](https://lovi.care/skincare/ca/ingredients/pro-retinol-and-lactic-acid)
- Keep them apart: [Retinal and lactic acid](https://lovi.care/skincare/ca/ingredients/retinal-and-lactic-acid)
- Keep them apart: [Lactic acid and retinoid blend](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-retinoid-blend)
- Keep them apart: [Tretinoin and lactic acid](https://lovi.care/skincare/ca/ingredients/tretinoin-and-lactic-acid)
- Work well together: [AHA blend glycolic and citric acids and gluconolactone](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-gluconolactone)
- Work well together: [Gluconolactone and citric acid](https://lovi.care/skincare/ca/ingredients/gluconolactone-and-citric-acid)
- Work well together: [Glycolic acid and gluconolactone](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-gluconolactone)
- Work well together: [Lactic acid and lactobionic acid](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-lactobionic-acid)
- Work well together: [Mandelic acid and gluconolactone](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-gluconolactone)
- Work well together: [Vitamin C and gluconolactone](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-gluconolactone)
- Work well together: [Lactic acid and cholesterol](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-cholesterol)
- Work well together: [Lactic acid and lauric acid](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-lauric-acid)
- Work well together: [Linoleic acid and lactic acid](https://lovi.care/skincare/ca/ingredients/linoleic-acid-and-lactic-acid)
- Keep them apart: [Lactic acid and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-tri-ceramide-complex)
- Work well together: [Arginine and lactic acid](https://lovi.care/skincare/ca/ingredients/arginine-and-lactic-acid)
- Work well together: [Lactic acid and GABA](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-gaba)
- Work well together: [Silk amino acids and lactic acid](https://lovi.care/skincare/ca/ingredients/silk-amino-acids-and-lactic-acid)
- Work well together: [Lactic acid and taurine](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-taurine)
- Work well together: [Lactic acid and theanine](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-theanine)
- Work well together: [Salicylic acid and gluconolactone](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-gluconolactone)
- Work well together: [Ferulic acid and lactic acid](https://lovi.care/skincare/ca/ingredients/ferulic-acid-and-lactic-acid)
- Work well together: [Vitamin E and lactic acid](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-lactic-acid)
- Keep them apart: [Azelaic acid and lactic acid](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-lactic-acid)
- Keep them apart: [Salicylic acid and lactic acid](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-lactic-acid)
- Work well together: [Allantoin and lactic acid](https://lovi.care/skincare/ca/ingredients/allantoin-and-lactic-acid)
- Work well together: [Lactic acid and bisabolol](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-bisabolol)
- Work well together: [Panthenol and lactic acid](https://lovi.care/skincare/ca/ingredients/panthenol-and-lactic-acid)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/lactic-acid-and-gluconolactone
- United Kingdom: https://lovi.care/skincare/uk/ingredients/lactic-acid-and-gluconolactone
- Ireland: https://lovi.care/skincare/ie/ingredients/lactic-acid-and-gluconolactone
- Germany: https://lovi.care/skincare/de/ingredients/lactic-acid-and-gluconolactone
- France: https://lovi.care/skincare/fr/ingredients/lactic-acid-and-gluconolactone
- Italy: https://lovi.care/skincare/it/ingredients/lactic-acid-and-gluconolactone
- Netherlands: https://lovi.care/skincare/nl/ingredients/lactic-acid-and-gluconolactone
- Spain: https://lovi.care/skincare/es/ingredients/lactic-acid-and-gluconolactone
- Canada: https://lovi.care/skincare/ca/ingredients/lactic-acid-and-gluconolactone (this page)
- Australia: https://lovi.care/skincare/au/ingredients/lactic-acid-and-gluconolactone
- Singapore: https://lovi.care/skincare/sg/ingredients/lactic-acid-and-gluconolactone
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/lactic-acid-and-gluconolactone
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/lactic-acid-and-gluconolactone