# Hexapeptide and potassium hydroxide Page: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-potassium-hydroxide The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada. Keep them apart Use them at different times of day, applying the peptide first and the [potassium hydroxide](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide) later, because they clash in chemical balance. The potassium hydroxide makes the product too basic, which destroys the anti-aging benefits of the peptide and stops it from working. The shopper can separate them into morning and night routines or choose a gentler formula. - [All about hexapeptide](https://lovi.care/skincare/ca/ingredients/hexapeptide) - [All about potassium hydroxide](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide) ### [Hexapeptide](https://lovi.care/skincare/ca/ingredients/hexapeptide) products - [SkinCeuticals P-TOX](https://lovi.care/skincare/ca/p/skinceuticals/p-tox/for/mature-skin) — High fit ### [Potassium hydroxide](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide) products - [Glytone Mild Gel Cleanser](https://lovi.care/skincare/ca/p/glytone/mild-gel-cleanser/for/dark-spots) — High fit ## Questions and answers ### Can you use hexapeptide and potassium hydroxide together? No, you should keep [hexapeptide](https://lovi.care/skincare/ca/ingredients/hexapeptide) and [potassium hydroxide](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide) apart because peptides lose stability and activity in highly alkaline environments. Using them in the same routine may cause deamidation and oxidation. ### Which goes first, hexapeptide or potassium hydroxide? Keep hexapeptide and potassium hydroxide apart because highly alkaline environments degrade peptides. Use them in separate routines to maintain peptide stability and effectiveness. ### Are hexapeptide and potassium hydroxide good for sensitive skin? Keep hexapeptide and potassium hydroxide apart because alkaline environments cause peptides to lose stability and activity. Lovi gives them an incompatible fit for sensitive skin. ## Research on hexapeptide and potassium hydroxide - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013 - [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019 ## Other combinations - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ca/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-granactive-retinoid) - Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-hydroxypinacolone-retinoate) - Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-pro-retinol) - Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-retinal) - Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-retinoid-blend) - Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/ca/ingredients/retinol-and-hexapeptide) - Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/ca/ingredients/tretinoin-and-hexapeptide) - Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-vitamin-a) - Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-liposome) - Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-microcapsule) - Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-hexapeptide) - Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-betaine) - Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/ca/ingredients/glycerin-and-hexapeptide) - Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/ca/ingredients/niacinamide-and-hexapeptide) - Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/ca/ingredients/panthenol-and-hexapeptide) - Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-hexapeptide) - Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-arginine) - Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-gaba) - Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-silk-amino-acids) - Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-taurine) - Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide) - Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-citric-acid) - Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-lactic-acid) - Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-mandelic-acid) - Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/ca/ingredients/coenzyme-q10-and-hexapeptide) - Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/ca/ingredients/green-tea-and-hexapeptide) - Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-hexapeptide) - Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/ca/ingredients/ceramide-building-complex-and-hexapeptide) - Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-cholesterol) - Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-phytosphingosine) - Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-phytosterol) - Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-squalene) - Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-hexapeptide) - Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide) - Keep them apart: [Bio-placenta peptides and potassium hydroxide](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-potassium-hydroxide) - Keep them apart: [Potassium hydroxide and collagen peptide](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-collagen-peptide) - Keep them apart: [Potassium hydroxide and copper peptide](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-copper-peptide) - Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-baking-soda) - Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-bleach) - Keep them apart: [Potassium hydroxide and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-hexapeptide-9) - Keep them apart: [Potassium hydroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-palmitoyl-pentapeptide-4) - Keep them apart: [Potassium hydroxide and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-palmitoyl-tripeptide-1) - Keep them apart: [Potassium hydroxide and peptide-rich plasma](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-peptide-rich-plasma) - Keep them apart: [Potassium hydroxide and triple peptide blend](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-triple-peptide-blend) - Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-behenyl-alcohol) - Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-isopropyl-alcohol) - Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-polyvinyl-alcohol) - Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-copper) - Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-magnesium) - Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-zinc) - Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-hexapeptide) - Keep them apart: [Vitamin C and potassium hydroxide](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-potassium-hydroxide) - Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-protease) - Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/hexapeptide-and-potassium-hydroxide - United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-potassium-hydroxide - Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-potassium-hydroxide - Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-potassium-hydroxide - France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-potassium-hydroxide - Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-potassium-hydroxide - Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-potassium-hydroxide - Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-potassium-hydroxide - Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-potassium-hydroxide (this page) - Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-potassium-hydroxide - Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-potassium-hydroxide - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-potassium-hydroxide - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-potassium-hydroxide