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Hexapeptide and phytosphingosine

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Hexapeptide and phytosphingosine: work well together

Work well together

Use them together by applying the hexapeptide first and the phytosphingosine right after, because lipids help the peptide absorb better. Phytosphingosine reinforces your skin barrier while the hexapeptide smooths out fine lines, making them work wonderfully as a team. You do not need to change anything, but you can wait a minute between steps if your skin is sensitive.

Hexapeptide products

Phytosphingosine products

Questions and answers

Can you use hexapeptide and phytosphingosine together?

Yes, hexapeptide and phytosphingosine work well together to enhance skin repair and barrier support, as lipids help improve peptide absorption and reinforce skin structure.

Which goes first, hexapeptide or phytosphingosine?

Hexapeptide and phytosphingosine work well together, and you can combine them to enhance skin barrier repair and support. Lipids like phytosphingosine help improve peptide absorption while reinforcing the skin structure.

Journal of the European Academy of Dermatology and Venereology, 2002

Are hexapeptide and phytosphingosine good for sensitive skin?

Hexapeptide and phytosphingosine work well together to enhance skin barrier support and repair. Combining them helps improve skin structure, making them beneficial for dry, mature, and barrier-impaired skin.

Journal of Cosmetic Dermatology, 2017Journal of the European Academy of Dermatology and Venereology, 2002

Research on hexapeptide and phytosphingosine

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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