# Copper peptide and protease Page: https://lovi.care/skincare/ca/ingredients/copper-peptide-and-protease The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada. Keep them apart Use them at different times of day with [copper peptides](https://lovi.care/skincare/ca/ingredients/copper-peptide) in the morning and [protease](https://lovi.care/skincare/ca/ingredients/protease) at night, because they break each other down. Protease enzymes break down the bonds of copper peptides, making both ingredients completely useless on your skin. You can easily fix this by using one in your morning routine and the other at night. - [All about copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide) - [All about protease](https://lovi.care/skincare/ca/ingredients/protease) ### [Copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide) products - [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/ca/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [CA$39.50 at Amazon](https://www.amazon.ca/dp/B0C9DXGXZ3?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Biossance Squalane + Copper Peptide Rapid Plumping Serum](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dry-skin) — Superior fit — [CA$94.00 at Sephora](https://www.sephora.com/ca/en/product/biossance-squalane-copper-peptide-rapid-plumping-serum-P479304?skuId=2536076) - [Good Molecules Super Peptide Serum](https://lovi.care/skincare/ca/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [CA$26.40 at Amazon](https://www.amazon.ca/dp/B091MTKS35?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Allies of Skin Copper Tripeptide & Ectoin Advanced Repair Serum](https://lovi.care/skincare/ca/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/oily-acne-prone-skin) — High fit - [COSRX Advanced Snail Peptide Eye Cream](https://lovi.care/skincare/ca/p/cosrx/advanced-snail-peptide-eye-cream/for/dark-spots) — High fit — [CA$48.96 at Amazon](https://www.amazon.ca/dp/B07ZRF416W?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Hero Cosmetics Rescue Balm](https://lovi.care/skincare/ca/p/hero-cosmetics/rescue-balm/for/mature-skin) — High fit — [CA$14.97 at Amazon](https://www.amazon.ca/dp/B0DN87PY6V?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Mederma PM Intensive Overnight Scar Cream](https://lovi.care/skincare/ca/p/mederma/pm-intensive-overnight-scar-cream/for/sensitive-skin) — High fit - [Perricone MD Cold Plasma Plus+](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/mature-skin) — Average fit — [CA$196.52 at Amazon](https://www.amazon.ca/dp/B0FWHBTQYK?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/ca/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit - [MISSHA Time Revolution Night Repair Ampoule](https://lovi.care/skincare/ca/p/missha/time-revolution-night-repair-ampoule/for/dark-spots) — High fit - [Peach & Lily Copper Peptide Pro Firming Serum](https://lovi.care/skincare/ca/p/peach-and-lily/copper-peptide-pro-firming-serum/for/mature-skin) — High fit - [Theramid Copper Peptide](https://lovi.care/skincare/ca/p/theramid/copper-peptide/for/oily-skin) — High fit ### [Protease](https://lovi.care/skincare/ca/ingredients/protease) products - [COSRX Centella Cleansing Powder](https://lovi.care/skincare/ca/p/cosrx/centella-cleansing-powder/for/combination-skin) — Superior fit - [FANCL Deep Clear Washing Powder](https://lovi.care/skincare/ca/p/fancl/deep-clear-washing-powder/for/oily-skin) — High fit ## Questions and answers ### Can you use copper peptide and protease together? No, you should keep [copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide) and [protease](https://lovi.care/skincare/ca/ingredients/protease) apart in your routine because the enzymes degrade peptide bonds and render the actives inactive. You can separate them into different routines or days to avoid this breakdown. ### Which goes first, copper peptide or protease? Keep copper peptide and protease apart in your routine because the protease may degrade the peptide and render it inactive. Use them at separate times of day if you choose to use both. ### Are copper peptide and protease good for sensitive skin? No, you should keep copper peptide and protease apart because proteolytic enzymes degrade peptide bonds and render the actives inactive. You should avoid enzymatic ingredients in peptide-containing formulations. ## Research on copper peptide and protease - [Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate from fish skin with the serine collagenolytic protease from Pseudoalteromonas sp. SM9913](https://pubmed.ncbi.nlm.nih.gov/29146927/) Protease · Scientific Reports, 2017 - [Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin](https://pubmed.ncbi.nlm.nih.gov/16847171/) Copper peptide · Archives of Facial Plastic Surgery, 2006 - [Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu](https://pubmed.ncbi.nlm.nih.gov/42573538/) Copper peptide · Skin Research and Technology, 2026 ## Other combinations - Keep them apart: [Adapalene and copper peptide](https://lovi.care/skincare/ca/ingredients/adapalene-and-copper-peptide) - Keep them apart: [Granactive retinoid and copper peptide](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-copper-peptide) - Keep them apart: [Hydroxypinacolone retinoate and copper peptide](https://lovi.care/skincare/ca/ingredients/hydroxypinacolone-retinoate-and-copper-peptide) - Keep them apart: [Pro-retinol and copper peptide](https://lovi.care/skincare/ca/ingredients/pro-retinol-and-copper-peptide) - Keep them apart: [Retinal and copper peptide](https://lovi.care/skincare/ca/ingredients/retinal-and-copper-peptide) - Keep them apart: [Retinoid blend and copper peptide](https://lovi.care/skincare/ca/ingredients/retinoid-blend-and-copper-peptide) - Depends on the strength: [Retinol and copper peptide](https://lovi.care/skincare/ca/ingredients/retinol-and-copper-peptide) - Keep them apart: [Tretinoin and copper peptide](https://lovi.care/skincare/ca/ingredients/tretinoin-and-copper-peptide) - Keep them apart: [Vitamin A and copper peptide](https://lovi.care/skincare/ca/ingredients/vitamin-a-and-copper-peptide) - Work well together: [Liposome and copper peptide](https://lovi.care/skincare/ca/ingredients/liposome-and-copper-peptide) - Work well together: [Microcapsule and copper peptide](https://lovi.care/skincare/ca/ingredients/microcapsule-and-copper-peptide) - Keep them apart: [Vitamin C and copper peptide](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-copper-peptide) - Work well together: [Betaine and copper peptide](https://lovi.care/skincare/ca/ingredients/betaine-and-copper-peptide) - Work well together: [Glycerin and copper peptide](https://lovi.care/skincare/ca/ingredients/glycerin-and-copper-peptide) - Work well together: [Hyaluronic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/hyaluronic-acid-and-copper-peptide) - Depends on the strength: [Niacinamide and copper peptide](https://lovi.care/skincare/ca/ingredients/niacinamide-and-copper-peptide) - Work well together: [Panthenol and copper peptide](https://lovi.care/skincare/ca/ingredients/panthenol-and-copper-peptide) - Work well together: [Bakuchiol and copper peptide](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-copper-peptide) - Work well together: [Arginine and copper peptide](https://lovi.care/skincare/ca/ingredients/arginine-and-copper-peptide) - Work well together: [Copper peptide and GABA](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-gaba) - Work well together: [Silk amino acids and copper peptide](https://lovi.care/skincare/ca/ingredients/silk-amino-acids-and-copper-peptide) - Work well together: [Taurine and copper peptide](https://lovi.care/skincare/ca/ingredients/taurine-and-copper-peptide) - Work well together: [Copper peptide and theanine](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and copper peptide](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-copper-peptide) - Keep them apart: [Copper peptide and citric acid](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-citric-acid) - Keep them apart: [Glycolic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-copper-peptide) - Keep them apart: [Lactic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-copper-peptide) - Keep them apart: [Mandelic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-copper-peptide) - Work well together: [Coenzyme Q10 and copper peptide](https://lovi.care/skincare/ca/ingredients/coenzyme-q10-and-copper-peptide) - Work well together: [Green tea and copper peptide](https://lovi.care/skincare/ca/ingredients/green-tea-and-copper-peptide) - Work well together: [Vitamin E and copper peptide](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-copper-peptide) - Work well together: [Copper peptide and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-beta-sitosterol) - Work well together: [Ceramide-building complex and copper peptide](https://lovi.care/skincare/ca/ingredients/ceramide-building-complex-and-copper-peptide) - Work well together: [Cholesterol and copper peptide](https://lovi.care/skincare/ca/ingredients/cholesterol-and-copper-peptide) - Work well together: [Phytosphingosine and copper peptide](https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-copper-peptide) - Work well together: [Phytosterol and copper peptide](https://lovi.care/skincare/ca/ingredients/phytosterol-and-copper-peptide) - Work well together: [Copper peptide and squalene](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-squalene) - Work well together: [Copper peptide and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-copper-peptide) - Keep them apart: [Copper peptide and baking soda](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-baking-soda) - Keep them apart: [Bleach and copper peptide](https://lovi.care/skincare/ca/ingredients/bleach-and-copper-peptide) - Keep them apart: [Potassium hydroxide and copper peptide](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-copper-peptide) - Keep them apart: [Copper peptide and behenyl alcohol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-behenyl-alcohol) - Keep them apart: [Copper peptide and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-isopropyl-alcohol) - Keep them apart: [Polyvinyl alcohol and copper peptide](https://lovi.care/skincare/ca/ingredients/polyvinyl-alcohol-and-copper-peptide) - Keep them apart: [Copper and copper peptide](https://lovi.care/skincare/ca/ingredients/copper-and-copper-peptide) - Keep them apart: [Benzoyl peroxide and copper peptide](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-copper-peptide) - Keep them apart: [Magnesium and copper peptide](https://lovi.care/skincare/ca/ingredients/magnesium-and-copper-peptide) - Keep them apart: [Zinc and copper peptide](https://lovi.care/skincare/ca/ingredients/zinc-and-copper-peptide) - Keep them apart: [Zinc sulfate and copper peptide](https://lovi.care/skincare/ca/ingredients/zinc-sulfate-and-copper-peptide) - Keep them apart: [Azelaic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-copper-peptide) - Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-protease) - Keep them apart: [Bio-placenta peptides and protease](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-protease) - Keep them apart: [Collagen peptide and protease](https://lovi.care/skincare/ca/ingredients/collagen-peptide-and-protease) - Keep them apart: [Superoxide dismutase and copper peptide](https://lovi.care/skincare/ca/ingredients/superoxide-dismutase-and-copper-peptide) - Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-protease) - Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-protease) - Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/protease-and-palmitoyl-pentapeptide-4) - Keep them apart: [Protease and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/protease-and-palmitoyl-tripeptide-1) - Keep them apart: [Peptide-rich plasma and protease](https://lovi.care/skincare/ca/ingredients/peptide-rich-plasma-and-protease) - Keep them apart: [Protease and triple peptide blend](https://lovi.care/skincare/ca/ingredients/protease-and-triple-peptide-blend) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/copper-peptide-and-protease - United Kingdom: https://lovi.care/skincare/uk/ingredients/copper-peptide-and-protease - Ireland: https://lovi.care/skincare/ie/ingredients/copper-peptide-and-protease - Germany: https://lovi.care/skincare/de/ingredients/copper-peptide-and-protease - France: https://lovi.care/skincare/fr/ingredients/copper-peptide-and-protease - Italy: https://lovi.care/skincare/it/ingredients/copper-peptide-and-protease - Netherlands: https://lovi.care/skincare/nl/ingredients/copper-peptide-and-protease - Spain: https://lovi.care/skincare/es/ingredients/copper-peptide-and-protease - Canada: https://lovi.care/skincare/ca/ingredients/copper-peptide-and-protease (this page) - Australia: https://lovi.care/skincare/au/ingredients/copper-peptide-and-protease - Singapore: https://lovi.care/skincare/sg/ingredients/copper-peptide-and-protease - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/copper-peptide-and-protease - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/copper-peptide-and-protease