# Bio-placenta peptides and mandelic acid

Page: https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-mandelic-acid

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Keep them apart

Use [mandelic acid](https://lovi.care/skincare/ca/ingredients/mandelic-acid) in the morning and [bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides) at night, because the acid breaks down the peptides. Mixing them makes both ingredients less effective and wastes their skin benefits. The shopper can separate them into different routines or use a gentler acid.

- [All about bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides)
- [All about mandelic acid](https://lovi.care/skincare/ca/ingredients/mandelic-acid)

### [Bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides) products

- [LION POSE PEP TALK](https://lovi.care/skincare/ca/p/lion-pose/pep-talk/for/dry-skin) — Average fit

### [Mandelic acid](https://lovi.care/skincare/ca/ingredients/mandelic-acid) products

- [The Ordinary Mandelic Acid 10% + HA](https://lovi.care/skincare/ca/p/the-ordinary/mandelic-acid-10-ha/for/acne-prone-skin) — Superior fit — [CA$10.30 at Amazon](https://www.amazon.ca/dp/B07BGJMNYL?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Nécessaire The Body Retinol](https://lovi.care/skincare/ca/p/necessaire/the-body-retinol/for/dark-spots) — Average fit
- [Good Molecules Mandelic Acid Serum](https://lovi.care/skincare/ca/p/good-molecules/mandelic-acid-serum/for/dry-sensitive-skin) — Superior fit
- [Glamglow Supermud Clearing Treatment](https://lovi.care/skincare/ca/p/glamglow/supermud-clearing-treatment/for/oily-skin) — High fit — [CA$75.42 at Amazon](https://www.amazon.ca/dp/B07DHSKYXR?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Dermalogica PowerBright Dark Spot Peel](https://lovi.care/skincare/ca/p/dermalogica/powerbright-dark-spot-peel/for/oily-skin) — Average fit
- [Sofie Pavitt Face Mandelic Clearing Serum](https://lovi.care/skincare/ca/p/sofie-pavitt-face/mandelic-clearing-serum/for/oily-acne-prone-skin) — High fit
- [Cetaphil Gentle Exfoliating SA Lotion](https://lovi.care/skincare/ca/p/cetaphil/gentle-exfoliating-sa-lotion/for/combination-skin) — High fit — [CA$22.79 at Amazon](https://www.amazon.ca/dp/B0DLLLD2KQ?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [SkinCeuticals Cell Cycle Catalyst](https://lovi.care/skincare/ca/p/skinceuticals/cell-cycle-catalyst/for/oily-acne-prone-skin) — Average fit
- [DIME TBT Serum](https://lovi.care/skincare/ca/p/dime/tbt-serum/for/dry-sensitive-skin) — High fit
- [By Wishtrend Mandelic Acid 5% Skin Prep Water](https://lovi.care/skincare/ca/p/by-wishtrend/mandelic-acid-5-skin-prep-water/for/acne-prone-skin) — High fit
- [Haruharu Wonder Black Rice Triple AHA Gentle Cleansing Gel](https://lovi.care/skincare/ca/p/haruharu-wonder/black-rice-triple-aha-gentle-cleansing-gel/for/oily-acne-prone-skin) — High fit — [CA$24.99 at Amazon](https://www.amazon.ca/dp/B0CKVL9PGY?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Neutrogena Bright Boost Gel Cream](https://lovi.care/skincare/ca/p/neutrogena/bright-boost-gel-cream/for/acne-prone-skin) — High fit

## Questions and answers

### Can you use bio-placenta peptides and mandelic acid together?

No, you should keep [bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides) and [mandelic acid](https://lovi.care/skincare/ca/ingredients/mandelic-acid) apart in your routine because the acidic environment of mandelic acid may destabilize the peptide bonds and reduce their effectiveness. Instead, use them in separate steps or routines, such as applying mandelic acid in the morning and peptides at night.

### Which goes first, bio-placenta peptides or mandelic acid?

Keep bio-placenta peptides and mandelic acid apart by using them in separate steps or routines, such as AM and PM separation, because the low pH of mandelic acid destabilizes the peptides.

### Are bio-placenta peptides and mandelic acid good for sensitive skin?

No, you should keep bio-placenta peptides and mandelic acid apart in your routine because the acidic environment of mandelic acid may break down peptide bonds and reduce their effectiveness. Instead, use them in separate steps or routines, such as AM and PM, to protect sensitive skin.

## Research on bio-placenta peptides and mandelic acid

- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [Chemical peels for acne vulgaris: a systematic review of randomised controlled trials](https://pubmed.ncbi.nlm.nih.gov/29705755/) Mandelic acid · BMJ Open, 2018

## Other combinations

- Keep them apart: [Benzoyl peroxide and mandelic acid](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-mandelic-acid)
- Keep them apart: [Retinol and mandelic acid](https://lovi.care/skincare/ca/ingredients/retinol-and-mandelic-acid)
- Depends on the strength: [Niacinamide and mandelic acid](https://lovi.care/skincare/ca/ingredients/niacinamide-and-mandelic-acid)
- Work well together: [Mandelic acid and sodium lactate](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-sodium-lactate)
- Work well together: [Mandelic acid and tromethamine](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-tromethamine)
- Keep them apart: [Adapalene and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/adapalene-and-bio-placenta-peptides)
- Keep them apart: [Bio-placenta peptides and granactive retinoid](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-granactive-retinoid)
- Keep them apart: [Bio-placenta peptides and hydroxypinacolone retinoate](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-hydroxypinacolone-retinoate)
- Keep them apart: [Bio-placenta peptides and pro-retinol](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-pro-retinol)
- Keep them apart: [Bio-placenta peptides and retinal](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-retinal)
- Keep them apart: [Bio-placenta peptides and retinoid blend](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-retinoid-blend)
- Depends on the strength: [Retinol and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/retinol-and-bio-placenta-peptides)
- Keep them apart: [Tretinoin and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/tretinoin-and-bio-placenta-peptides)
- Keep them apart: [Bio-placenta peptides and vitamin A](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-vitamin-a)
- Work well together: [Bio-placenta peptides and liposome](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-liposome)
- Work well together: [Bio-placenta peptides and microcapsule](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-microcapsule)
- Keep them apart: [Vitamin C and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-bio-placenta-peptides)
- Work well together: [Bio-placenta peptides and betaine](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-betaine)
- Work well together: [Glycerin and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/glycerin-and-bio-placenta-peptides)
- Work well together: [Bio-placenta peptides and hyaluronic acid](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-hyaluronic-acid)
- Work well together: [Mandelic acid and betaine](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-betaine)
- Work well together: [Glycerin and mandelic acid](https://lovi.care/skincare/ca/ingredients/glycerin-and-mandelic-acid)
- Depends on the strength: [Mandelic acid and hyaluronic acid](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/niacinamide-and-bio-placenta-peptides)
- Work well together: [Panthenol and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/panthenol-and-bio-placenta-peptides)
- Work well together: [Bio-placenta peptides and bakuchiol](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-bakuchiol)
- Work well together: [Bio-placenta peptides and arginine](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-arginine)
- Work well together: [Bio-placenta peptides and GABA](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-gaba)
- Work well together: [Bio-placenta peptides and silk amino acids](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-silk-amino-acids)
- Work well together: [Bio-placenta peptides and taurine](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-taurine)
- Work well together: [Bio-placenta peptides and theanine](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-bio-placenta-peptides)
- Keep them apart: [Bio-placenta peptides and citric acid](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-citric-acid)
- Keep them apart: [Glycolic acid and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-bio-placenta-peptides)
- Keep them apart: [Bio-placenta peptides and lactic acid](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-lactic-acid)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Keep them apart: [Carnosine and mandelic acid](https://lovi.care/skincare/ca/ingredients/carnosine-and-mandelic-acid)
- Keep them apart: [Mandelic acid and collagen peptide](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-collagen-peptide)
- Keep them apart: [Mandelic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-copper-peptide)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-mandelic-acid)
- Keep them apart: [Mandelic acid and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-hexapeptide-9)
- Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Mandelic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Mandelic acid and peptide-rich plasma](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-peptide-rich-plasma)
- Keep them apart: [Mandelic acid and triple peptide blend](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-triple-peptide-blend)
- Work well together: [Bio-placenta peptides and coenzyme q10](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-coenzyme-q10)
- Work well together: [Green tea and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/green-tea-and-bio-placenta-peptides)
- Work well together: [Bio-placenta peptides and vitamin E](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-vitamin-e)
- Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/ca/ingredients/adapalene-and-mandelic-acid)
- Keep them apart: [Mandelic acid and granactive retinoid](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-granactive-retinoid)
- Keep them apart: [Mandelic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and mandelic acid](https://lovi.care/skincare/ca/ingredients/pro-retinol-and-mandelic-acid)
- Keep them apart: [Retinal and mandelic acid](https://lovi.care/skincare/ca/ingredients/retinal-and-mandelic-acid)
- Keep them apart: [Mandelic acid and retinoid blend](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-retinoid-blend)
- Keep them apart: [Tretinoin and mandelic acid](https://lovi.care/skincare/ca/ingredients/tretinoin-and-mandelic-acid)
- Work well together: [Bio-placenta peptides and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/ceramide-building-complex-and-bio-placenta-peptides)
- Work well together: [Bio-placenta peptides and cholesterol](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-cholesterol)
- Work well together: [Bio-placenta peptides and phytosphingosine](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-phytosphingosine)
- Work well together: [Bio-placenta peptides and phytosterol](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-phytosterol)
- Work well together: [Bio-placenta peptides and squalene](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-squalene)
- Work well together: [Bio-placenta peptides and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-tri-ceramide-complex)
- Work well together: [Mandelic acid and gluconolactone](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-gluconolactone)
- Work well together: [Mandelic acid and lactobionic acid](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-lactobionic-acid)
- Keep them apart: [Salicylic acid and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-bio-placenta-peptides)
- Work well together: [Mandelic acid and cholesterol](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-cholesterol)
- Work well together: [Mandelic acid and lauric acid](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-lauric-acid)
- Work well together: [Linoleic acid and mandelic acid](https://lovi.care/skincare/ca/ingredients/linoleic-acid-and-mandelic-acid)
- Keep them apart: [Mandelic acid and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-tri-ceramide-complex)
- Work well together: [Arginine and mandelic acid](https://lovi.care/skincare/ca/ingredients/arginine-and-mandelic-acid)
- Work well together: [Mandelic acid and GABA](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-gaba)
- Work well together: [Silk amino acids and mandelic acid](https://lovi.care/skincare/ca/ingredients/silk-amino-acids-and-mandelic-acid)
- Work well together: [Taurine and mandelic acid](https://lovi.care/skincare/ca/ingredients/taurine-and-mandelic-acid)
- Work well together: [Mandelic acid and theanine](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-theanine)
- Keep them apart: [Bio-placenta peptides and baking soda](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-baking-soda)
- Keep them apart: [Bio-placenta peptides and bleach](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-bleach)
- Keep them apart: [Bio-placenta peptides and potassium hydroxide](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-potassium-hydroxide)
- Keep them apart: [Bio-placenta peptides and behenyl alcohol](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-behenyl-alcohol)
- Keep them apart: [Bio-placenta peptides and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-isopropyl-alcohol)
- Keep them apart: [Bio-placenta peptides and polyvinyl alcohol](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-polyvinyl-alcohol)
- Work well together: [Ferulic acid and mandelic acid](https://lovi.care/skincare/ca/ingredients/ferulic-acid-and-mandelic-acid)
- Work well together: [Vitamin E and mandelic acid](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-mandelic-acid)
- Keep them apart: [Bio-placenta peptides and copper](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-copper)
- Keep them apart: [Azelaic acid and mandelic acid](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-mandelic-acid)
- Keep them apart: [Salicylic acid and mandelic acid](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-mandelic-acid)
- Work well together: [Allantoin and mandelic acid](https://lovi.care/skincare/ca/ingredients/allantoin-and-mandelic-acid)
- Work well together: [Mandelic acid and bisabolol](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-bisabolol)
- Work well together: [Panthenol and mandelic acid](https://lovi.care/skincare/ca/ingredients/panthenol-and-mandelic-acid)
- Keep them apart: [Bio-placenta peptides and magnesium](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-magnesium)
- Keep them apart: [Bio-placenta peptides and zinc](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-zinc)
- Keep them apart: [Bio-placenta peptides and zinc sulfate](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-bio-placenta-peptides)
- Keep them apart: [Azelaic acid and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-bio-placenta-peptides)
- Keep them apart: [Bio-placenta peptides and protease](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-protease)
- Keep them apart: [Bio-placenta peptides and superoxide dismutase](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/bio-placenta-peptides-and-mandelic-acid
- United Kingdom: https://lovi.care/skincare/uk/ingredients/bio-placenta-peptides-and-mandelic-acid
- Ireland: https://lovi.care/skincare/ie/ingredients/bio-placenta-peptides-and-mandelic-acid
- Germany: https://lovi.care/skincare/de/ingredients/bio-placenta-peptides-and-mandelic-acid
- France: https://lovi.care/skincare/fr/ingredients/bio-placenta-peptides-and-mandelic-acid
- Italy: https://lovi.care/skincare/it/ingredients/bio-placenta-peptides-and-mandelic-acid
- Netherlands: https://lovi.care/skincare/nl/ingredients/bio-placenta-peptides-and-mandelic-acid
- Spain: https://lovi.care/skincare/es/ingredients/bio-placenta-peptides-and-mandelic-acid
- Canada: https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-mandelic-acid (this page)
- Australia: https://lovi.care/skincare/au/ingredients/bio-placenta-peptides-and-mandelic-acid
- Singapore: https://lovi.care/skincare/sg/ingredients/bio-placenta-peptides-and-mandelic-acid
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/bio-placenta-peptides-and-mandelic-acid
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/bio-placenta-peptides-and-mandelic-acid