# Bakuchiol and hexapeptide

Page: https://lovi.care/skincare/ca/ingredients/bakuchiol-and-hexapeptide

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Work well together

Use them together in the same routine, applying your [bakuchiol](https://lovi.care/skincare/ca/ingredients/bakuchiol) product first and then your [hexapeptide](https://lovi.care/skincare/ca/ingredients/hexapeptide) cream. They work together to help firm your skin and boost [collagen](https://lovi.care/skincare/ca/ingredients/collagen) production for a smoother look. You can use your usual strength since these ingredients are gentle when paired.

- [All about bakuchiol](https://lovi.care/skincare/ca/ingredients/bakuchiol)
- [All about hexapeptide](https://lovi.care/skincare/ca/ingredients/hexapeptide)

### [Bakuchiol](https://lovi.care/skincare/ca/ingredients/bakuchiol) products

- [Good Molecules Gentle Retinol Cream](https://lovi.care/skincare/ca/p/good-molecules/gentle-retinol-cream/for/mature-skin) — High fit — [CA$14.49 at Shoppers Drug Mart](https://www.shoppersdrugmart.ca/good-molecules-gentle-retinol-cream/p/BB_810019610875?variantCode=810019610875)
- [BYOMA Moisturizing Rich Cream](https://lovi.care/skincare/ca/p/byoma/moisturizing-rich-cream/for/dry-skin) — Superior fit — [CA$23.00 at Shoppers Drug Mart](https://www.shoppersdrugmart.ca/byoma-moisturizing-rich-cream/p/BB_5060489793461?variantCode=5060489793461)
- [NATURIUM Retinol Complex Serum](https://lovi.care/skincare/ca/p/naturium/retinol-complex-serum/for/acne-prone-skin) — High fit
- [Some By Mi Retinol Intense Reactivating Serum](https://lovi.care/skincare/ca/p/some-by-mi/retinol-intense-reactivating-serum/for/oily-acne-prone-skin) — High fit
- [Haruharu Wonder Black Rice Bakuchiol Eye Cream](https://lovi.care/skincare/ca/p/haruharu-wonder/black-rice-bakuchiol-eye-cream/for/dry-skin) — Superior fit — [CA$17.99 at Amazon](https://www.amazon.ca/dp/B09ZB7GDJL?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Cetaphil Healthy Radiance Renewing Cream](https://lovi.care/skincare/ca/p/cetaphil/healthy-radiance-renewing-cream/for/dark-spots) — Superior fit
- [DIME TBT Serum](https://lovi.care/skincare/ca/p/dime/tbt-serum/for/dry-sensitive-skin) — High fit
- [Medik8 Bakuchiol Peptides](https://lovi.care/skincare/ca/p/medik8/bakuchiol-peptides/for/dry-skin) — Superior fit — [CA$82.00 at Sephora](https://www.sephora.com/ca/en/product/bakuchiol-peptides-serum-P525907?skuId=3011251)
- [K-SECRET SEOUL 1988 Serum](https://lovi.care/skincare/ca/p/k-secret/seoul-1988-serum/for/mature-skin) — Average fit — [CA$28.99 at Amazon](https://www.amazon.ca/dp/B0CP3C7TTJ?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Biossance Squalane + Phyto-Retinol Serum](https://lovi.care/skincare/ca/p/biossance/squalane-phyto-retinol-serum/for/dry-skin) — Superior fit
- [Avène Vitamin Activ Cg Radiance Concentrated Serum](https://lovi.care/skincare/ca/p/avene/vitamin-activ-cg-radiance-concentrated-serum/for/mature-skin) — High fit — [CA$77.00 at Amazon](https://www.amazon.ca/dp/B0CPYN8FVC?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Paula's Choice Discoloration Repair Serum](https://lovi.care/skincare/ca/p/paula-s-choice/discoloration-repair-serum/for/dry-skin) — High fit — [CA$99.00 at Sephora](https://www.sephora.com/ca/en/product/paulas-choice-25-vitamin-c-glutathione-clinical-serum-P510467?skuId=2744464)

### [Hexapeptide](https://lovi.care/skincare/ca/ingredients/hexapeptide) products

- [SkinCeuticals P-TOX](https://lovi.care/skincare/ca/p/skinceuticals/p-tox/for/mature-skin) — High fit

## Questions and answers

### Can you use bakuchiol and hexapeptide together?

Yes, you can use [bakuchiol](https://lovi.care/skincare/ca/ingredients/bakuchiol) and [hexapeptide](https://lovi.care/skincare/ca/ingredients/hexapeptide) together because they work in synergy to support [collagen](https://lovi.care/skincare/ca/ingredients/collagen) and firmness. Lovi gives this combination a Superior fit.

### Which goes first, bakuchiol or hexapeptide?

Bakuchiol and hexapeptide work well together, and you can layer them in anti-aging [serums](https://lovi.care/skincare/ca/ingredients/serum) or creams for cumulative firming benefits. Because they act synergistically to support collagen and firmness, the order of application depends on the specific product textures rather than a strict rule.

### Are bakuchiol and hexapeptide good for sensitive skin?

Yes, bakuchiol and hexapeptide work well together for all skin types, including sensitive skin. They combine to support collagen and firmness, while topical bakuchiol may also help improve barrier function and reduce redness and sensitivity.

[Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/)

## Research on bakuchiol and hexapeptide

- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013
- [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019
- [A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial](https://pubmed.ncbi.nlm.nih.gov/25914553/) Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025

## Other combinations

- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ca/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-granactive-retinoid)
- Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-hydroxypinacolone-retinoate)
- Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-pro-retinol)
- Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-retinal)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-retinoid-blend)
- Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/ca/ingredients/retinol-and-hexapeptide)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/ca/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-vitamin-a)
- Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-liposome)
- Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-microcapsule)
- Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-hexapeptide)
- Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-betaine)
- Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/ca/ingredients/glycerin-and-hexapeptide)
- Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/ca/ingredients/niacinamide-and-hexapeptide)
- Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/ca/ingredients/panthenol-and-hexapeptide)
- Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-acetyl-hexapeptide-3)
- Work well together: [Bio-placenta peptides and bakuchiol](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-bakuchiol)
- Work well together: [Bakuchiol and collagen peptide](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-collagen-peptide)
- Work well together: [Bakuchiol and copper peptide](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-copper-peptide)
- Work well together: [Bakuchiol and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-hexapeptide-9)
- Work well together: [Bakuchiol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-palmitoyl-pentapeptide-4)
- Work well together: [Bakuchiol and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-palmitoyl-tripeptide-1)
- Work well together: [Bakuchiol and peptide-rich plasma](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-peptide-rich-plasma)
- Work well together: [Bakuchiol and triple peptide blend](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-triple-peptide-blend)
- Work well together: [Retinol and bakuchiol](https://lovi.care/skincare/ca/ingredients/retinol-and-bakuchiol)
- Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-arginine)
- Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-gaba)
- Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-silk-amino-acids)
- Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-taurine)
- Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide)
- Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-citric-acid)
- Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/ca/ingredients/coenzyme-q10-and-hexapeptide)
- Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/ca/ingredients/green-tea-and-hexapeptide)
- Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-hexapeptide)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/ca/ingredients/ceramide-building-complex-and-hexapeptide)
- Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-cholesterol)
- Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-phytosphingosine)
- Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-phytosterol)
- Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-squalene)
- Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-tri-ceramide-complex)
- Work well together: [Bakuchiol and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-tri-ceramide-complex)
- Work well together: [Niacinamide and bakuchiol](https://lovi.care/skincare/ca/ingredients/niacinamide-and-bakuchiol)
- Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-baking-soda)
- Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-bleach)
- Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-potassium-hydroxide)
- Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-behenyl-alcohol)
- Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-isopropyl-alcohol)
- Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-polyvinyl-alcohol)
- Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-copper)
- Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-magnesium)
- Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-zinc)
- Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-hexapeptide)
- Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-hexapeptide)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/bakuchiol-and-hexapeptide
- United Kingdom: https://lovi.care/skincare/uk/ingredients/bakuchiol-and-hexapeptide
- Ireland: https://lovi.care/skincare/ie/ingredients/bakuchiol-and-hexapeptide
- Germany: https://lovi.care/skincare/de/ingredients/bakuchiol-and-hexapeptide
- France: https://lovi.care/skincare/fr/ingredients/bakuchiol-and-hexapeptide
- Italy: https://lovi.care/skincare/it/ingredients/bakuchiol-and-hexapeptide
- Netherlands: https://lovi.care/skincare/nl/ingredients/bakuchiol-and-hexapeptide
- Spain: https://lovi.care/skincare/es/ingredients/bakuchiol-and-hexapeptide
- Canada: https://lovi.care/skincare/ca/ingredients/bakuchiol-and-hexapeptide (this page)
- Australia: https://lovi.care/skincare/au/ingredients/bakuchiol-and-hexapeptide
- Singapore: https://lovi.care/skincare/sg/ingredients/bakuchiol-and-hexapeptide
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/bakuchiol-and-hexapeptide
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/bakuchiol-and-hexapeptide