# Azelaic acid and palmitoyl pentapeptide-4 Page: https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada. Keep them apart Use them at different times of day by applying [azelaic acid](https://lovi.care/skincare/ca/ingredients/azelaic-acid) in the morning and peptides at night because mixing them lowers their effectiveness. Azelaic acid creates an acidic environment that breaks down the peptide bonds, making the anti-aging ingredients less effective on your skin. You can easily fix this by using one in the morning and the other at night, or by waiting longer between applying them. - [All about azelaic acid](https://lovi.care/skincare/ca/ingredients/azelaic-acid) - [All about palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/palmitoyl-pentapeptide-4) ### [Azelaic acid](https://lovi.care/skincare/ca/ingredients/azelaic-acid) products - [The Ordinary Azelaic Acid Suspension 10%](https://lovi.care/skincare/ca/p/the-ordinary/azelaic-acid-suspension-10/for/acne-prone-skin) — High fit — [CA$15.80 at Amazon](https://www.amazon.ca/dp/B06WD5J8KY?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Paula's Choice 10% Azelaic Acid Booster](https://lovi.care/skincare/ca/p/paula-s-choice/10-azelaic-acid-booster/for/acne-prone-skin) — High fit — [CA$58.00 at Amazon](https://www.amazon.ca/dp/B0CLFPDVZ4?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Topicals Faded Serum](https://lovi.care/skincare/ca/p/topicals/faded-serum/for/oily-acne-prone-skin) — Superior fit — [CA$24.50 at Sephora](https://www.sephora.com/ca/en/product/faded-brightening-clearing-serum-for-dark-spots-discoloration-P515090?skuId=2842755) - [NATURIUM Azelaic Topical Acid 10%](https://lovi.care/skincare/ca/p/naturium/azelaic-topical-acid-10/for/acne-prone-skin) — Superior fit — [CA$33.99 at Amazon](https://www.amazon.ca/dp/B0DZ3NNTTM?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Musely The Spot Cream](https://lovi.care/skincare/ca/p/musely/the-spot-cream/for/mature-skin) — High fit - [Topicals Faded Brightening & Clearing Serum](https://lovi.care/skincare/ca/p/topicals/faded-brightening-and-clearing-serum/for/acne-prone-skin) — High fit - [Bioderma Pigmentbio Sensitive Areas](https://lovi.care/skincare/ca/p/bioderma/pigmentbio-sensitive-areas/for/oily-acne-prone-skin) — High fit — [CA$47.99 at Amazon](https://www.amazon.ca/dp/B09231D8X3?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Peach Slices Redness Relief Azelaic Acid Serum](https://lovi.care/skincare/ca/p/peach-slices/redness-relief-azelaic-acid-serum/for/sensitive-skin) — High fit - [Finacea Gel](https://lovi.care/skincare/ca/p/finacea/gel/for/oily-acne-prone-skin) — High fit - [NATURIUM Niacinamide Cleansing Gelée 3%](https://lovi.care/skincare/ca/p/naturium/niacinamide-cleansing-gelee-3/for/acne-prone-skin) — High fit - [NATURIUM Azelaic Acid Emulsion 10%](https://lovi.care/skincare/ca/p/naturium/azelaic-acid-emulsion-10/for/acne-prone-skin) — High fit — [CA$33.99 at Amazon](https://www.amazon.ca/dp/B0DZ3NNTTM?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [StriVectin Daily Reveal Exfoliating Pads](https://lovi.care/skincare/ca/p/strivectin/daily-reveal-exfoliating-pads/for/oily-skin) — Average fit — [CA$49.00 at Amazon](https://www.amazon.ca/dp/B089TPYFX3?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) ### [Palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/palmitoyl-pentapeptide-4) products - [Olay Eye Lifting Serum](https://lovi.care/skincare/ca/p/olay/eye-lifting-serum/for/dry-skin) — High fit — [CA$49.99 at Amazon](https://www.amazon.ca/dp/B01EHW5MAE?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use azelaic acid and palmitoyl pentapeptide-4 together? Keep [azelaic acid](https://lovi.care/skincare/ca/ingredients/azelaic-acid) and [palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/palmitoyl-pentapeptide-4) apart because low-pH acids can break down peptides and reduce their effectiveness. Use them in separate steps or in alternating morning and evening routines. ### Which goes first, azelaic acid or palmitoyl pentapeptide-4? Keep azelaic acid and palmitoyl pentapeptide-4 apart by using them in separate steps or routines, such as morning and evening separation, because low-pH acids should not be combined directly with peptides. ### Are azelaic acid and palmitoyl pentapeptide-4 good for sensitive skin? Keep azelaic acid and palmitoyl pentapeptide-4 apart by using them in separate steps or different routines like AM and PM. Combining low-pH acids directly with peptides may hydrolyze peptide bonds and reduce their activity. ## Research on azelaic acid and palmitoyl pentapeptide-4 - [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study](https://pubmed.ncbi.nlm.nih.gov/36729399/) Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023 - [Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis](https://pubmed.ncbi.nlm.nih.gov/42500768/) Palmitoyl pentapeptide-4 · Cureus, 2026 ## Other combinations - Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/adapalene-and-palmitoyl-pentapeptide-4) - Keep them apart: [Granactive retinoid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4) - Keep them apart: [Pro-retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/pro-retinol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Retinal and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/retinal-and-palmitoyl-pentapeptide-4) - Keep them apart: [Retinoid blend and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/retinoid-blend-and-palmitoyl-pentapeptide-4) - Depends on the strength: [Retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/retinol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Tretinoin and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/tretinoin-and-palmitoyl-pentapeptide-4) - Keep them apart: [Vitamin A and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4) - Work well together: [Liposome and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/liposome-and-palmitoyl-pentapeptide-4) - Work well together: [Microcapsule and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/microcapsule-and-palmitoyl-pentapeptide-4) - Depends on the strength: [Vitamin C and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-palmitoyl-pentapeptide-4) - Work well together: [Betaine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/betaine-and-palmitoyl-pentapeptide-4) - Work well together: [Glycerin and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/glycerin-and-palmitoyl-pentapeptide-4) - Work well together: [Hyaluronic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/hyaluronic-acid-and-palmitoyl-pentapeptide-4) - Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/niacinamide-and-palmitoyl-pentapeptide-4) - Work well together: [Panthenol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/panthenol-and-palmitoyl-pentapeptide-4) - Work well together: [Bakuchiol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Azelaic acid and hyaluronic acid](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-hyaluronic-acid) - Work well together: [Arginine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/arginine-and-palmitoyl-pentapeptide-4) - Work well together: [GABA and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/gaba-and-palmitoyl-pentapeptide-4) - Work well together: [Silk amino acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/silk-amino-acids-and-palmitoyl-pentapeptide-4) - Work well together: [Taurine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/taurine-and-palmitoyl-pentapeptide-4) - Work well together: [Palmitoyl pentapeptide-4 and theanine](https://lovi.care/skincare/ca/ingredients/palmitoyl-pentapeptide-4-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-pentapeptide-4) - Keep them apart: [Citric acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/citric-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Glycolic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4) - Work well together: [Coenzyme Q10 and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/coenzyme-q10-and-palmitoyl-pentapeptide-4) - Work well together: [Green tea and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/green-tea-and-palmitoyl-pentapeptide-4) - Work well together: [Vitamin E and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4) - Work well together: [Beta-sitosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/beta-sitosterol-and-palmitoyl-pentapeptide-4) - Work well together: [Ceramide-building complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/ceramide-building-complex-and-palmitoyl-pentapeptide-4) - Work well together: [Cholesterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/cholesterol-and-palmitoyl-pentapeptide-4) - Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4) - Work well together: [Phytosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/phytosterol-and-palmitoyl-pentapeptide-4) - Work well together: [Squalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/squalene-and-palmitoyl-pentapeptide-4) - Work well together: [Tri-ceramide complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/tri-ceramide-complex-and-palmitoyl-pentapeptide-4) - Keep them apart: [Salicylic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Baking soda and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/baking-soda-and-palmitoyl-pentapeptide-4) - Keep them apart: [Bleach and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/bleach-and-palmitoyl-pentapeptide-4) - Keep them apart: [Potassium hydroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-palmitoyl-pentapeptide-4) - Keep them apart: [Behenyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/behenyl-alcohol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Isopropyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/isopropyl-alcohol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Polyvinyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/polyvinyl-alcohol-and-palmitoyl-pentapeptide-4) - Keep them apart: [Copper and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/copper-and-palmitoyl-pentapeptide-4) - Keep them apart: [Azelaic acid and aha blend glycolic and citric acids](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-aha-blend-glycolic-and-citric-acids) - Keep them apart: [Azelaic acid and citric acid](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-citric-acid) - Keep them apart: [Glycolic acid and azelaic acid](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-azelaic-acid) - Keep them apart: [Azelaic acid and lactic acid](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-lactic-acid) - Keep them apart: [Azelaic acid and mandelic acid](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-mandelic-acid) - Keep them apart: [Azelaic acid and salicylic acid](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-salicylic-acid) - Keep them apart: [Benzoyl peroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-palmitoyl-pentapeptide-4) - Keep them apart: [Magnesium and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/magnesium-and-palmitoyl-pentapeptide-4) - Keep them apart: [Zinc and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/zinc-and-palmitoyl-pentapeptide-4) - Keep them apart: [Zinc sulfate and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/zinc-sulfate-and-palmitoyl-pentapeptide-4) - Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Azelaic acid and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-bio-placenta-peptides) - Keep them apart: [Azelaic acid and collagen peptide](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-collagen-peptide) - Keep them apart: [Azelaic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-copper-peptide) - Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-hexapeptide) - Keep them apart: [Azelaic acid and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-hexapeptide-9) - Keep them apart: [Azelaic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Azelaic acid and peptide-rich plasma](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-peptide-rich-plasma) - Keep them apart: [Azelaic acid and triple peptide blend](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-triple-peptide-blend) - Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/protease-and-palmitoyl-pentapeptide-4) - Keep them apart: [Superoxide dismutase and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 - United Kingdom: https://lovi.care/skincare/uk/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 - Ireland: https://lovi.care/skincare/ie/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 - Germany: https://lovi.care/skincare/de/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 - France: https://lovi.care/skincare/fr/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 - Italy: https://lovi.care/skincare/it/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 - Netherlands: https://lovi.care/skincare/nl/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 - Spain: https://lovi.care/skincare/es/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 - Canada: https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 (this page) - Australia: https://lovi.care/skincare/au/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 - Singapore: https://lovi.care/skincare/sg/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4