# Adapalene and copper peptide

Page: https://lovi.care/skincare/ca/ingredients/adapalene-and-copper-peptide

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Keep them apart

Use them at different times of day, applying [copper peptides](https://lovi.care/skincare/ca/ingredients/copper-peptide) in the morning and [adapalene](https://lovi.care/skincare/ca/ingredients/adapalene) at night, to prevent skin irritation. Using both strong ingredients at the same time can overwhelm the skin and cause redness or irritation. To fix this, a shopper can use them in separate routines or alternate nights.

- [All about adapalene](https://lovi.care/skincare/ca/ingredients/adapalene)
- [All about copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide)

### [Adapalene](https://lovi.care/skincare/ca/ingredients/adapalene) products

- [Differin Gel](https://lovi.care/skincare/ca/p/differin/gel/for/oily-acne-prone-skin) — High fit
- [Galderma Epiduo Gel](https://lovi.care/skincare/ca/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit
- [La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment](https://lovi.care/skincare/ca/p/la-roche-posay/effaclar-adapalene-gel-0-1-acne-treatment/for/oily-skin) — Superior fit

### [Copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide) products

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/ca/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [CA$39.50 at Amazon](https://www.amazon.ca/dp/B0C9DXGXZ3?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Biossance Squalane + Copper Peptide Rapid Plumping Serum](https://lovi.care/skincare/ca/p/biossance/squalane-copper-peptide-rapid-plumping-serum/for/dry-skin) — Superior fit — [CA$94.00 at Sephora](https://www.sephora.com/ca/en/product/biossance-squalane-copper-peptide-rapid-plumping-serum-P479304?skuId=2536076)
- [Good Molecules Super Peptide Serum](https://lovi.care/skincare/ca/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [CA$26.40 at Amazon](https://www.amazon.ca/dp/B091MTKS35?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Allies of Skin Copper Tripeptide & Ectoin Advanced Repair Serum](https://lovi.care/skincare/ca/p/allies-of-skin/copper-tripeptide-and-ectoin-advanced-repair-serum/for/oily-acne-prone-skin) — High fit
- [COSRX Advanced Snail Peptide Eye Cream](https://lovi.care/skincare/ca/p/cosrx/advanced-snail-peptide-eye-cream/for/dark-spots) — High fit — [CA$48.96 at Amazon](https://www.amazon.ca/dp/B07ZRF416W?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Hero Cosmetics Rescue Balm](https://lovi.care/skincare/ca/p/hero-cosmetics/rescue-balm/for/mature-skin) — High fit — [CA$14.97 at Amazon](https://www.amazon.ca/dp/B0DN87PY6V?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Mederma PM Intensive Overnight Scar Cream](https://lovi.care/skincare/ca/p/mederma/pm-intensive-overnight-scar-cream/for/sensitive-skin) — High fit
- [Perricone MD Cold Plasma Plus+](https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/mature-skin) — Average fit — [CA$196.52 at Amazon](https://www.amazon.ca/dp/B0FWHBTQYK?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/ca/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit
- [MISSHA Time Revolution Night Repair Ampoule](https://lovi.care/skincare/ca/p/missha/time-revolution-night-repair-ampoule/for/dark-spots) — High fit
- [Peach & Lily Copper Peptide Pro Firming Serum](https://lovi.care/skincare/ca/p/peach-and-lily/copper-peptide-pro-firming-serum/for/mature-skin) — High fit
- [Theramid Copper Peptide](https://lovi.care/skincare/ca/p/theramid/copper-peptide/for/oily-skin) — High fit

## Questions and answers

### Can you use adapalene and copper peptide together?

No, you should keep [adapalene](https://lovi.care/skincare/ca/ingredients/adapalene) and [copper peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide) apart in your routine because combining them may increase skin irritation. Instead, try alternating usage by applying your retinoid in the evening and peptides in the morning.

### Which goes first, adapalene or copper peptide?

Keep adapalene and copper peptide apart in your routine because combining them may increase irritation. Instead, alternate their usage by applying your retinoid in the evening and peptides in the morning.

### Are adapalene and copper peptide good for sensitive skin?

Adapalene and copper peptide should be kept apart in your routine because combining them may increase skin irritation. To use both safely, alternate your usage by applying adapalene at night and copper peptides in the morning.

## Research on adapalene and copper peptide

- [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene · American Journal of Clinical Dermatology, 2018
- [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Adapalene · American Journal of Clinical Dermatology, 2022
- [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene · Archives of Dermatological Research, 2022
- [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023
- [Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin](https://pubmed.ncbi.nlm.nih.gov/16847171/) Copper peptide · Archives of Facial Plastic Surgery, 2006
- [Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu](https://pubmed.ncbi.nlm.nih.gov/42573538/) Copper peptide · Skin Research and Technology, 2026

## Other combinations

- Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/adapalene-and-acetyl-hexapeptide-3)
- Keep them apart: [Adapalene and bio-placenta peptides](https://lovi.care/skincare/ca/ingredients/adapalene-and-bio-placenta-peptides)
- Keep them apart: [Adapalene and collagen peptide](https://lovi.care/skincare/ca/ingredients/adapalene-and-collagen-peptide)
- Keep them apart: [Granactive retinoid and copper peptide](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-copper-peptide)
- Keep them apart: [Hydroxypinacolone retinoate and copper peptide](https://lovi.care/skincare/ca/ingredients/hydroxypinacolone-retinoate-and-copper-peptide)
- Keep them apart: [Pro-retinol and copper peptide](https://lovi.care/skincare/ca/ingredients/pro-retinol-and-copper-peptide)
- Keep them apart: [Retinal and copper peptide](https://lovi.care/skincare/ca/ingredients/retinal-and-copper-peptide)
- Keep them apart: [Retinoid blend and copper peptide](https://lovi.care/skincare/ca/ingredients/retinoid-blend-and-copper-peptide)
- Depends on the strength: [Retinol and copper peptide](https://lovi.care/skincare/ca/ingredients/retinol-and-copper-peptide)
- Keep them apart: [Tretinoin and copper peptide](https://lovi.care/skincare/ca/ingredients/tretinoin-and-copper-peptide)
- Keep them apart: [Vitamin A and copper peptide](https://lovi.care/skincare/ca/ingredients/vitamin-a-and-copper-peptide)
- Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/ca/ingredients/adapalene-and-hexapeptide)
- Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/adapalene-and-hexapeptide-9)
- Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/adapalene-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Adapalene and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/adapalene-and-palmitoyl-tripeptide-1)
- Keep them apart: [Adapalene and peptide-rich plasma](https://lovi.care/skincare/ca/ingredients/adapalene-and-peptide-rich-plasma)
- Keep them apart: [Adapalene and triple peptide blend](https://lovi.care/skincare/ca/ingredients/adapalene-and-triple-peptide-blend)
- Work well together: [Liposome and copper peptide](https://lovi.care/skincare/ca/ingredients/liposome-and-copper-peptide)
- Work well together: [Microcapsule and copper peptide](https://lovi.care/skincare/ca/ingredients/microcapsule-and-copper-peptide)
- Keep them apart: [Vitamin C and copper peptide](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-copper-peptide)
- Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/ca/ingredients/adapalene-and-niacinamide)
- Work well together: [Betaine and copper peptide](https://lovi.care/skincare/ca/ingredients/betaine-and-copper-peptide)
- Work well together: [Glycerin and copper peptide](https://lovi.care/skincare/ca/ingredients/glycerin-and-copper-peptide)
- Work well together: [Hyaluronic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/hyaluronic-acid-and-copper-peptide)
- Depends on the strength: [Niacinamide and copper peptide](https://lovi.care/skincare/ca/ingredients/niacinamide-and-copper-peptide)
- Work well together: [Panthenol and copper peptide](https://lovi.care/skincare/ca/ingredients/panthenol-and-copper-peptide)
- Work well together: [Bakuchiol and copper peptide](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-copper-peptide)
- Work well together: [Arginine and copper peptide](https://lovi.care/skincare/ca/ingredients/arginine-and-copper-peptide)
- Work well together: [Copper peptide and GABA](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-gaba)
- Work well together: [Silk amino acids and copper peptide](https://lovi.care/skincare/ca/ingredients/silk-amino-acids-and-copper-peptide)
- Work well together: [Taurine and copper peptide](https://lovi.care/skincare/ca/ingredients/taurine-and-copper-peptide)
- Work well together: [Copper peptide and theanine](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and copper peptide](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-copper-peptide)
- Keep them apart: [Copper peptide and citric acid](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-citric-acid)
- Keep them apart: [Glycolic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-copper-peptide)
- Keep them apart: [Lactic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-copper-peptide)
- Keep them apart: [Mandelic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-copper-peptide)
- Work well together: [Coenzyme Q10 and copper peptide](https://lovi.care/skincare/ca/ingredients/coenzyme-q10-and-copper-peptide)
- Work well together: [Green tea and copper peptide](https://lovi.care/skincare/ca/ingredients/green-tea-and-copper-peptide)
- Work well together: [Vitamin E and copper peptide](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-copper-peptide)
- Keep them apart: [Adapalene and aha blend glycolic and citric acids](https://lovi.care/skincare/ca/ingredients/adapalene-and-aha-blend-glycolic-and-citric-acids)
- Keep them apart: [Adapalene and citric acid](https://lovi.care/skincare/ca/ingredients/adapalene-and-citric-acid)
- Keep them apart: [Adapalene and glycolic acid](https://lovi.care/skincare/ca/ingredients/adapalene-and-glycolic-acid)
- Keep them apart: [Adapalene and lactic acid](https://lovi.care/skincare/ca/ingredients/adapalene-and-lactic-acid)
- Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/ca/ingredients/adapalene-and-mandelic-acid)
- Work well together: [Copper peptide and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and copper peptide](https://lovi.care/skincare/ca/ingredients/ceramide-building-complex-and-copper-peptide)
- Work well together: [Cholesterol and copper peptide](https://lovi.care/skincare/ca/ingredients/cholesterol-and-copper-peptide)
- Work well together: [Phytosphingosine and copper peptide](https://lovi.care/skincare/ca/ingredients/phytosphingosine-and-copper-peptide)
- Work well together: [Phytosterol and copper peptide](https://lovi.care/skincare/ca/ingredients/phytosterol-and-copper-peptide)
- Work well together: [Copper peptide and squalene](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-squalene)
- Work well together: [Copper peptide and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-copper-peptide)
- Keep them apart: [Adapalene and salicylic acid](https://lovi.care/skincare/ca/ingredients/adapalene-and-salicylic-acid)
- Keep them apart: [Adapalene and vitamin C](https://lovi.care/skincare/ca/ingredients/adapalene-and-vitamin-c)
- Keep them apart: [Copper peptide and baking soda](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-baking-soda)
- Keep them apart: [Bleach and copper peptide](https://lovi.care/skincare/ca/ingredients/bleach-and-copper-peptide)
- Keep them apart: [Potassium hydroxide and copper peptide](https://lovi.care/skincare/ca/ingredients/potassium-hydroxide-and-copper-peptide)
- Keep them apart: [Copper peptide and behenyl alcohol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-behenyl-alcohol)
- Keep them apart: [Copper peptide and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-isopropyl-alcohol)
- Keep them apart: [Polyvinyl alcohol and copper peptide](https://lovi.care/skincare/ca/ingredients/polyvinyl-alcohol-and-copper-peptide)
- Keep them apart: [Copper and copper peptide](https://lovi.care/skincare/ca/ingredients/copper-and-copper-peptide)
- Keep them apart: [Adapalene and benzoyl peroxide](https://lovi.care/skincare/ca/ingredients/adapalene-and-benzoyl-peroxide)
- Keep them apart: [Benzoyl peroxide and copper peptide](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-copper-peptide)
- Keep them apart: [Magnesium and copper peptide](https://lovi.care/skincare/ca/ingredients/magnesium-and-copper-peptide)
- Keep them apart: [Zinc and copper peptide](https://lovi.care/skincare/ca/ingredients/zinc-and-copper-peptide)
- Keep them apart: [Zinc sulfate and copper peptide](https://lovi.care/skincare/ca/ingredients/zinc-sulfate-and-copper-peptide)
- Keep them apart: [Azelaic acid and copper peptide](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-copper-peptide)
- Keep them apart: [Copper peptide and protease](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-protease)
- Keep them apart: [Superoxide dismutase and copper peptide](https://lovi.care/skincare/ca/ingredients/superoxide-dismutase-and-copper-peptide)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/adapalene-and-copper-peptide
- United Kingdom: https://lovi.care/skincare/uk/ingredients/adapalene-and-copper-peptide
- Ireland: https://lovi.care/skincare/ie/ingredients/adapalene-and-copper-peptide
- Germany: https://lovi.care/skincare/de/ingredients/adapalene-and-copper-peptide
- France: https://lovi.care/skincare/fr/ingredients/adapalene-and-copper-peptide
- Italy: https://lovi.care/skincare/it/ingredients/adapalene-and-copper-peptide
- Netherlands: https://lovi.care/skincare/nl/ingredients/adapalene-and-copper-peptide
- Spain: https://lovi.care/skincare/es/ingredients/adapalene-and-copper-peptide
- Canada: https://lovi.care/skincare/ca/ingredients/adapalene-and-copper-peptide (this page)
- Australia: https://lovi.care/skincare/au/ingredients/adapalene-and-copper-peptide
- Singapore: https://lovi.care/skincare/sg/ingredients/adapalene-and-copper-peptide
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/adapalene-and-copper-peptide
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/adapalene-and-copper-peptide