# Acetyl hexapeptide-3 and granactive retinoid Page: https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada. Keep them apart Use them at different times of day by applying your peptide product in the morning and your retinoid at night. Using both strong ingredients at the same time can overwhelm your skin and cause extra redness or irritation. You can easily prevent this by using them in separate routines or switching to a gentler formula. - [All about acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3) - [All about granactive retinoid](https://lovi.care/skincare/ca/ingredients/granactive-retinoid) ### [Acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3) products - [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/ca/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [CA$39.50 at Amazon](https://www.amazon.ca/dp/B0C9DXGXZ3?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/ca/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [CA$23.50 at Amazon](https://www.amazon.ca/dp/B0BLHW7JZM?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Medik8 Liquid Peptides](https://lovi.care/skincare/ca/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [CA$133.00 at Amazon](https://www.amazon.ca/dp/B0DT1LYVZ6?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [La Mer The Treatment Lotion](https://lovi.care/skincare/ca/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [CA$182.00 at Sephora](https://www.sephora.com/ca/en/product/la-mer-the-treatment-lotion-P480613?skuId=2533594) - [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/ca/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit — [CA$30.00 at Sephora](https://www.sephora.com/ca/en/product/peptide-glazing-fluid-P517531?skuId=2895902) - [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/ca/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit — [CA$12.90 at Amazon](https://www.amazon.ca/dp/B072JH13CD?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Good Molecules Super Peptide Serum](https://lovi.care/skincare/ca/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [CA$26.40 at Amazon](https://www.amazon.ca/dp/B091MTKS35?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [CA$145.00 at Amazon](https://www.amazon.ca/dp/B09FG8TJDD?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [La Mer The Renewal Oil](https://lovi.care/skincare/ca/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [CA$410.02 at Amazon](https://www.amazon.ca/dp/B0163GAMI4?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/ca/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit — [CA$107.00 at Amazon](https://www.amazon.ca/dp/B0BB44W3QP?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/ca/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit - [La Mer The Eye Concentrate](https://lovi.care/skincare/ca/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [CA$370.00 at Sephora](https://www.sephora.com/ca/en/product/la-mer-the-eye-concentrate-P455924?skuId=2341600) ### [Granactive retinoid](https://lovi.care/skincare/ca/ingredients/granactive-retinoid) products - [The Ordinary Granactive Retinoid 2% Emulsion](https://lovi.care/skincare/ca/p/the-ordinary/granactive-retinoid-2-emulsion/for/oily-skin) — High fit ## Questions and answers ### Can you use acetyl hexapeptide-3 and granactive retinoid together? No, you should keep [acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3) and [granactive retinoid](https://lovi.care/skincare/ca/ingredients/granactive-retinoid) apart because combining them may increase skin irritation. Instead, alternate their usage by applying your retinoid in the evening and peptides in the morning. ### Which goes first, acetyl hexapeptide-3 or granactive retinoid? Keep acetyl hexapeptide-3 and granactive retinoid apart in your routine because combining them may increase irritation. Instead, alternate your usage by applying the retinoid in the evening and the peptides in the morning. ### Are acetyl hexapeptide-3 and granactive retinoid good for sensitive skin? No, you should keep acetyl hexapeptide-3 and granactive retinoid apart in your routine because combining them may increase skin irritation. Instead, alternate their usage by applying your retinoid in the evening and peptides in the morning. ## Research on acetyl hexapeptide-3 and granactive retinoid - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019 - [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017 - [Efficacy and safety of a new topical gel formulation containing retinol encapsulated in glycospheres and hydroxypinacolone retinoate, an antimicrobial peptide, salicylic acid, glycolic acid and niacinamide for the treatment of mild acne: preliminary results of a 2-month prospective study](https://pubmed.ncbi.nlm.nih.gov/32869963/) Granactive retinoid · Giornale Italiano Di Dermatologia E Venereologia, 2020 - [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013 ## Other combinations - Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/adapalene-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate) - Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/pro-retinol-and-acetyl-hexapeptide-3) - Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/retinal-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-retinoid-blend) - Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/retinol-and-acetyl-hexapeptide-3) - Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/tretinoin-and-acetyl-hexapeptide-3) - Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/vitamin-a-and-acetyl-hexapeptide-3) - Keep them apart: [Bio-placenta peptides and granactive retinoid](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-granactive-retinoid) - Keep them apart: [Granactive retinoid and collagen peptide](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-collagen-peptide) - Keep them apart: [Granactive retinoid and copper peptide](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-copper-peptide) - Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-granactive-retinoid) - Keep them apart: [Granactive retinoid and hexapeptide-9](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-hexapeptide-9) - Keep them apart: [Granactive retinoid and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-palmitoyl-pentapeptide-4) - Keep them apart: [Granactive retinoid and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-palmitoyl-tripeptide-1) - Keep them apart: [Granactive retinoid and peptide-rich plasma](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-peptide-rich-plasma) - Keep them apart: [Granactive retinoid and triple peptide blend](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-triple-peptide-blend) - Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/liposome-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-microcapsule) - Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-acetyl-hexapeptide-3) - Depends on the strength: [Niacinamide and granactive retinoid](https://lovi.care/skincare/ca/ingredients/niacinamide-and-granactive-retinoid) - Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-betaine) - Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/glycerin-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/niacinamide-and-acetyl-hexapeptide-3) - Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/panthenol-and-acetyl-hexapeptide-3) - Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-acetyl-hexapeptide-3) - Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/arginine-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-gaba) - Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3) - Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/taurine-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-citric-acid) - Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-mandelic-acid) - Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3) - Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/green-tea-and-acetyl-hexapeptide-3) - Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-acetyl-hexapeptide-3) - Keep them apart: [AHA blend glycolic and citric acids and granactive retinoid](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-granactive-retinoid) - Keep them apart: [Granactive retinoid and citric acid](https://lovi.care/skincare/ca/ingredients/granactive-retinoid-and-citric-acid) - Keep them apart: [Glycolic acid and granactive retinoid](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-granactive-retinoid) - Keep them apart: [Lactic acid and granactive retinoid](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-granactive-retinoid) - Keep them apart: [Mandelic acid and granactive retinoid](https://lovi.care/skincare/ca/ingredients/mandelic-acid-and-granactive-retinoid) - Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol) - Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-cholesterol) - Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-phytosphingosine) - Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-phytosterol) - Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-squalene) - Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Salicylic acid and granactive retinoid](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-granactive-retinoid) - Keep them apart: [Vitamin C and granactive retinoid](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-granactive-retinoid) - Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-baking-soda) - Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-bleach) - Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide) - Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol) - Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol) - Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol) - Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/copper-and-acetyl-hexapeptide-3) - Keep them apart: [Benzoyl peroxide and granactive retinoid](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-granactive-retinoid) - Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/magnesium-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-zinc) - Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3) - Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-protease) - Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid - United Kingdom: https://lovi.care/skincare/uk/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid - Ireland: https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid - Germany: https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid - France: https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid - Italy: https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid - Netherlands: https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid - Spain: https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid - Canada: https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid (this page) - Australia: https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid - Singapore: https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid