# Acetyl hexapeptide-3 and beta-sitosterol

Page: https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Work well together

Use them together in the same routine, applying the plant sterol first and the peptide right after, because lipids help peptides absorb better. The lipid ingredient helps the peptide sink in better so they team up to strengthen your skin barrier. You can keep using them together as long as your skin feels comfortable, but try a gentler strength or space them out if you notice any irritation.

- [All about acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3)
- [All about beta-sitosterol](https://lovi.care/skincare/ca/ingredients/beta-sitosterol)

### [Acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3) products

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/ca/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [CA$39.50 at Amazon](https://www.amazon.ca/dp/B0C9DXGXZ3?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/ca/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [CA$23.50 at Amazon](https://www.amazon.ca/dp/B0BLHW7JZM?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Medik8 Liquid Peptides](https://lovi.care/skincare/ca/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [CA$133.00 at Amazon](https://www.amazon.ca/dp/B0DT1LYVZ6?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [La Mer The Treatment Lotion](https://lovi.care/skincare/ca/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [CA$182.00 at Sephora](https://www.sephora.com/ca/en/product/la-mer-the-treatment-lotion-P480613?skuId=2533594)
- [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/ca/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit — [CA$30.00 at Sephora](https://www.sephora.com/ca/en/product/peptide-glazing-fluid-P517531?skuId=2895902)
- [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/ca/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit — [CA$12.90 at Amazon](https://www.amazon.ca/dp/B072JH13CD?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Good Molecules Super Peptide Serum](https://lovi.care/skincare/ca/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [CA$26.40 at Amazon](https://www.amazon.ca/dp/B091MTKS35?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/ca/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [CA$145.00 at Amazon](https://www.amazon.ca/dp/B09FG8TJDD?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [La Mer The Renewal Oil](https://lovi.care/skincare/ca/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [CA$410.02 at Amazon](https://www.amazon.ca/dp/B0163GAMI4?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/ca/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit — [CA$107.00 at Amazon](https://www.amazon.ca/dp/B0BB44W3QP?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/ca/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit
- [La Mer The Eye Concentrate](https://lovi.care/skincare/ca/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [CA$370.00 at Sephora](https://www.sephora.com/ca/en/product/la-mer-the-eye-concentrate-P455924?skuId=2341600)

### [Beta-sitosterol](https://lovi.care/skincare/ca/ingredients/beta-sitosterol) products

- [Bioderma Atoderm Intensive Baume](https://lovi.care/skincare/ca/p/bioderma/atoderm-intensive-baume/for/dry-skin) — Average fit — [CA$38.99 at Amazon](https://www.amazon.ca/dp/B0161ZC5GY?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use acetyl hexapeptide-3 and beta-sitosterol together?

Yes, [acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3) and [beta-sitosterol](https://lovi.care/skincare/ca/ingredients/beta-sitosterol) work well together to enhance skin repair and barrier support. Lovi rates this combination as Superior for dry, mature, and barrier-impaired skin.

### Which goes first, acetyl hexapeptide-3 or beta-sitosterol?

There is no set order for applying acetyl hexapeptide-3 and beta-sitosterol, as they work well together to support skin barrier repair. Combining them helps improve peptide absorption and reinforce skin structure.

### Are acetyl hexapeptide-3 and beta-sitosterol good for sensitive skin?

Acetyl hexapeptide-3 and beta-sitosterol work well together because lipid components like beta-sitosterol improve peptide absorption and reinforce skin structure. This combination helps repair the skin barrier, making it particularly beneficial for dry, mature, and barrier-impaired skin.

## Research on acetyl hexapeptide-3 and beta-sitosterol

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

## Other combinations

- Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/adapalene-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid)
- Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/pro-retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/retinal-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-retinoid-blend)
- Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/tretinoin-and-acetyl-hexapeptide-3)
- Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/vitamin-a-and-acetyl-hexapeptide-3)
- Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/liposome-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-microcapsule)
- Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/vitamin-c-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-betaine)
- Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/glycerin-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/niacinamide-and-acetyl-hexapeptide-3)
- Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/panthenol-and-acetyl-hexapeptide-3)
- Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/bakuchiol-and-acetyl-hexapeptide-3)
- Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/arginine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-gaba)
- Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3)
- Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/taurine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-citric-acid)
- Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/glycolic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/lactic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3)
- Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/green-tea-and-acetyl-hexapeptide-3)
- Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/vitamin-e-and-acetyl-hexapeptide-3)
- Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-cholesterol)
- Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-phytosphingosine)
- Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-phytosterol)
- Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-squalene)
- Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex)
- Work well together: [Bio-placenta peptides and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/bio-placenta-peptides-and-beta-sitosterol)
- Work well together: [Collagen peptide and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/collagen-peptide-and-beta-sitosterol)
- Work well together: [Copper peptide and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/copper-peptide-and-beta-sitosterol)
- Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/hexapeptide-and-beta-sitosterol)
- Work well together: [Hexapeptide-9 and beta-sitosterol](https://lovi.care/skincare/ca/ingredients/hexapeptide-9-and-beta-sitosterol)
- Work well together: [Beta-sitosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/ca/ingredients/beta-sitosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Beta-sitosterol and palmitoyl tripeptide-1](https://lovi.care/skincare/ca/ingredients/beta-sitosterol-and-palmitoyl-tripeptide-1)
- Work well together: [Beta-sitosterol and peptide-rich plasma](https://lovi.care/skincare/ca/ingredients/beta-sitosterol-and-peptide-rich-plasma)
- Work well together: [Beta-sitosterol and triple peptide blend](https://lovi.care/skincare/ca/ingredients/beta-sitosterol-and-triple-peptide-blend)
- Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/salicylic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-baking-soda)
- Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-bleach)
- Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide)
- Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol)
- Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/copper-and-acetyl-hexapeptide-3)
- Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/magnesium-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-zinc)
- Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3)
- Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/ca/ingredients/azelaic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-protease)
- Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol
- United Kingdom: https://lovi.care/skincare/uk/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol
- Ireland: https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol
- Germany: https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol
- France: https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol
- Italy: https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol
- Netherlands: https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol
- Spain: https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol
- Canada: https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol (this page)
- Australia: https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol
- Singapore: https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol