# Theramid vs Natura Bissé

Page: https://lovi.care/skincare/ca/compare/theramid-vs-natura-bisse

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Theramid and Natura Bissé are Spanish skincare brands that offer advanced moisturizers and carefully crafted treatments. The newer brand is known for targeted [serums](https://lovi.care/skincare/ca/ingredients/serum) featuring meticulously engineered formulas like its Ceramide Treatment, [Copper Peptide](https://lovi.care/skincare/ca/ingredients/copper-peptide), and DERMA-PEPTIDES, which suit balanced, dry, combination, oily, and sensitive skin best. Meanwhile, the older brand is loved for rich, nourishing products such as the Diamond Extreme, which suit mature, dry, and sensitive skin best. They differ primarily in their founding years, ownership, and specific ingredient compositions.

Theramid is a Spanish skincare brand founded in 2022 and owned by Cosnova Group since 2026.

[cosmeticsbusiness.com](https://cosmeticsbusiness.com/cosnova-acquires-niche-beauty-labs-expand-skin-care)

Natura Bissé is a Spanish skincare brand founded in 1979 and owned by Natura Bissé International, S.A..

[naturabisse.com](https://www.naturabisse.com/int/en/our-story.html) [tracxn.com](https://tracxn.com/d/accelerator-incubator/ushopal/__yjGH7DKhQGNWnINKarEuFce6tilrPzGJv0PnASFLfpg)

This page compares some of the most popular Theramid and Natura Bissé products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg663da5acd2).

### Popular Theramid vs Natura Bissé products

#### Natura Bissé

- [Diamond Extreme](https://lovi.care/skincare/ca/p/natura-bisse/diamond-extreme/for/mature-skin) — Superior fit

#### Theramid

- [Copper Peptide](https://lovi.care/skincare/ca/p/theramid/copper-peptide/for/oily-skin) — High fit
- [DERMA-PEPTIDES](https://lovi.care/skincare/ca/p/theramid/derma-peptides/for/mature-skin) — High fit
- [Ceramide Treatment](https://lovi.care/skincare/ca/p/theramid/ceramide-treatment/for/dry-sensitive-skin) — Superior fit

## Questions and answers

### Theramid or Natura Bissé: which is better?

Theramid is generally a better choice for fragrance-sensitive routines, as every product on this page is fragrance-free. Meanwhile, Natura Bissé offers options like Diamond Extreme, which has a Superior fit for mature skin but contains added fragrance.

### What is the difference between Theramid and Natura Bissé?

Theramid products on this page list no fragrance, whereas Natura Bissé includes fragrance in Diamond Extreme. Reviewers often mention formulation and compatibility issues for Theramid, and its Ceramide Treatment achieves a Superior Lovi fit for dry sensitive skin.

[Scientific Reports, 2022](https://pubmed.ncbi.nlm.nih.gov/35340018/)

### Theramid or Natura Bissé: which moisturizer is better?

For mature skin, Natura Bissé Diamond Extreme achieves a Superior Lovi fit, whereas Theramid Ceramide Treatment and DERMA-PEPTIDES achieve High and Average fits respectively. Shoppers often mention formulation and compatibility issues with Theramid products, while every Theramid product on this page lists no fragrance compared to Natura Bissé Diamond Extreme which includes fragrance.

### Which is more affordable, Theramid or Natura Bissé?

This page does not provide pricing information to compare the affordability of Theramid and Natura Bissé.

### Which causes fewer breakouts, Theramid or Natura Bissé?

Theramid is a better pick for acne-prone skin, as its Ceramide Treatment has a High Lovi fit for acne-prone skin and every product on this page lists no fragrance. In contrast, Natura Bissé Diamond Extreme has only an Average fit for acne-prone skin and contains fragrance.

### Which brand has been established longer in Spain, Theramid or Natura Bissé?

Natura Bissé has been established longer in Spain, having been founded in 1979 compared to Theramid, which was founded in 2022.

### Do any products from Theramid or Natura Bissé contain fragrance?

Theramid lists no fragrance in every product on this page, while Natura Bissé includes fragrance in its Diamond Extreme moisturizer.

### Which moisturizers are rated as Superior for mature skin between Theramid and Natura Bissé?

Natura Bissé's Diamond Extreme is rated as Superior for mature skin among the moisturizers on this page. Theramid's Ceramide Treatment and DERMA-PEPTIDES achieve a High fit level for mature skin.

## Research behind their key ingredients

- [Hyaluronic acid and wound healing](https://pubmed.ncbi.nlm.nih.gov/25877441/) Sodium hyaluronate · Journal of Pharmacy & Pharmaceutical Sciences, 2015
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Madecassic acid · Indian Journal of Pharmaceutical Sciences, 2016
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramide · Scientific Reports, 2022
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32310680/) Madecassic acid · Journal of Alternative and Complementary Medicine, 2020
- [Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling](https://pubmed.ncbi.nlm.nih.gov/32098197/) Leontopodium alpinum leaf extract flower · Genes, 2020
- [Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells](https://pubmed.ncbi.nlm.nih.gov/23093820/) Leontopodium alpinum leaf extract flower · Mediators of Inflammation, 2012
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica · Molecules, 2023
- [The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro](https://pubmed.ncbi.nlm.nih.gov/37218728/) Bifida lysate ferment · Journal of Cosmetic Dermatology, 2023
- [Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function](https://pubmed.ncbi.nlm.nih.gov/35409270/) Rosamarinus officinalis leaf extract rosemary leaf extract · International Journal of Molecular Sciences, 2022
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters](https://pubmed.ncbi.nlm.nih.gov/37539499/) Ectoin · Journal of Cosmetic Dermatology, 2024
- [Formulation and evaluation of exotic fat based cosmeceuticals for skin repair](https://pubmed.ncbi.nlm.nih.gov/20046792/) Mangifera indica seed butter · Indian Journal of Pharmaceutical Sciences, 2008
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Augmented Skin Beneficial Effects of Thermus Thermophilus and Bacillus Subtilis Mixed-Culture Ferment Extract by Tripeptide GHK-Cu](https://pubmed.ncbi.nlm.nih.gov/42573538/) Copper tripeptide-1 · Skin Research and Technology, 2026
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1 · International Journal of Cosmetic Science, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025

## The brands

- Spanish skincare: [Theramid](https://lovi.care/skincare/ca/brands/theramid)
- Spanish skincare: [Natura Bissé](https://lovi.care/skincare/ca/brands/natura-bisse)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

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- Ireland: https://lovi.care/skincare/ie/compare/theramid-vs-natura-bisse
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- Netherlands: https://lovi.care/skincare/nl/compare/theramid-vs-natura-bisse
- Spain: https://lovi.care/skincare/es/compare/theramid-vs-natura-bisse
- Canada: https://lovi.care/skincare/ca/compare/theramid-vs-natura-bisse (this page)
- Australia: https://lovi.care/skincare/au/compare/theramid-vs-natura-bisse
- Singapore: https://lovi.care/skincare/sg/compare/theramid-vs-natura-bisse
- Saudi Arabia: https://lovi.care/skincare/sa/compare/theramid-vs-natura-bisse
- United Arab Emirates: https://lovi.care/skincare/ae/compare/theramid-vs-natura-bisse