# Sesderma vs the purest

Page: https://lovi.care/skincare/ca/compare/sesderma-vs-the-purest

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Sesderma and the purest are two distinct skincare lines known for addressing diverse dermatological needs through specialized formulations. Sesderma is beloved for its advanced [serums](https://lovi.care/skincare/ca/ingredients/serum) and meticulously engineered formulas, such as the Azelac RU Serum, featuring botanical [extracts](https://lovi.care/skincare/ca/ingredients/extract) and active compounds that suit sensitive, hyperpigmented, and aging skin types best. Meanwhile, the purest is deeply cherished for its gentle moisturizers and thoughtfully composed formulas that suit sensitive, dry, and combination skin best, while offering reliable daily support for acne-prone skin. While both brands cater well to sensitive skin, the Spanish enterprise focuses on refining skin texture and promoting a radiant complexion, whereas the second option earns praise through consistent, understated performance.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Sesderma and the purest products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pge91995cf7e).

### Popular Sesderma vs the purest products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/ca/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit

#### the purest

- [solutions](https://lovi.care/skincare/ca/p/the-purest/solutions/for/sensitive-skin) — High fit

## Questions and answers

### Sesderma or the purest: which is better?

For acne-prone or dark spot concerns, Sesderma is a better fit with a High Lovi rating for Azelac RU [Serum](https://lovi.care/skincare/ca/ingredients/serum), while the purest solutions moisturizer earns a High fit only for sensitive skin.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### What is the difference between Sesderma and the purest?

Sesderma and the purest are founded in different years and countries, with Sesderma established in Spain in 1989 and the purest launched in 2020. Additionally, the products on this page from both brands contain fragrance. For skin types, Lovi gives Sesderma's Azelac RU Serum a High fit for acne-prone skin and dark spots, while the purest's solutions gets a High fit for sensitive skin.

### Which is more affordable, Sesderma or the purest?

This page does not compare prices for Sesderma and the purest, so it is unclear which brand is more affordable.

### Which causes fewer breakouts, Sesderma or the purest?

For acne-prone skin, Sesderma offers a High fit with its Azelac RU Serum, whereas the purest provides only a Low fit for the products on this page. [Azelaic acid](https://lovi.care/skincare/ca/ingredients/azelaic-acid) helps reduce acne breakouts.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which brand is older, Sesderma or the purest?

Sesderma is older, having been founded in Spain in 1989, while the purest was founded more recently in 2020.

### Do both Sesderma and the purest include fragrance in their products on this page?

Yes, both Sesderma and the purest include fragrance in the products on this page.

### Which company owns Sesderma and which company owns the purest?

Grupo Sesderma owns Sesderma, and Evly Pharma Cosmetics owns the purest.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Hyaluronic acid · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Centella asiatica · Indian Journal of Pharmaceutical Sciences, 2016
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel · Phytochemistry, 2001
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica · Molecules, 2023
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Antiaging, Brightening, and Antioxidant Efficacy of Fermented Bilberry Extract (Vaccinium myrtillus): A Randomized, Double-Blind, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/39064646/) Vaccinium myrtillus · Nutrients, 2024
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Shea butter · Lasers in Medical Science, 2025

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/ca/brands/sesderma)
- Skincare: [the purest](https://lovi.care/skincare/ca/brands/the-purest)

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- [The Ordinary vs the purest](https://lovi.care/skincare/ca/compare/the-ordinary-vs-the-purest)
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- [CeraVe vs Sesderma](https://lovi.care/skincare/ca/compare/cerave-vs-sesderma)
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- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-sesderma)
- [La Roche-Posay vs the purest](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-the-purest)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/ca/compare/dr-althea-vs-sesderma)
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- [Some By Mi vs Sesderma](https://lovi.care/skincare/ca/compare/some-by-mi-vs-sesderma)
- [Some By Mi vs the purest](https://lovi.care/skincare/ca/compare/some-by-mi-vs-the-purest)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-the-purest (this page)
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