# Sesderma vs Noche Y Dia

Page: https://lovi.care/skincare/ca/compare/sesderma-vs-noche-y-dia

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Sesderma and Noche Y Dia are established Spanish skincare brands offering distinct approaches to daily wellness. Sesderma is beloved for its advanced [serums](https://lovi.care/skincare/ca/ingredients/serum) and meticulously engineered formulas featuring botanical [extracts](https://lovi.care/skincare/ca/ingredients/extract) and active compounds, suiting sensitive, hyperpigmented, and aging skin types best with standout options like the Azelac RU Serum. Conversely, the brand known as Noche Y Dia is widely loved for its targeted serums and balanced formulas that deliver gentle care, suiting dry, mature, and combination skin types best with essentials like the [Vitamin C](https://lovi.care/skincare/ca/ingredients/vitamin-c) Serum. While both brands refine skin texture and promote a radiant complexion, they differ primarily in their founding years, ownership, and ideal skin matches.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

Noche Y Dia is a Spanish skincare brand founded in 1965 and owned by Laboratorios Ximart S.A..

[nocheydia.eu](https://nocheydia.eu/en/legal-disclaimer/) [nocheskincare.com](https://www.nocheskincare.com/pages/story-brand-mature-skin)

This page compares some of the most popular Sesderma and Noche Y Dia products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg4d4041a731).

### Popular Sesderma vs Noche Y Dia products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/ca/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit

#### Noche Y Dia

- [Vitamin C Serum](https://lovi.care/skincare/ca/p/noche-y-dia/vitamin-c-serum/for/dark-spots) — High fit

### Sesderma vs Noche Y Dia [serums](https://lovi.care/skincare/ca/ingredients/serum) and treatments

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/ca/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit

#### Noche Y Dia

- [Vitamin C Serum](https://lovi.care/skincare/ca/p/noche-y-dia/vitamin-c-serum/for/dark-spots) — High fit

## Questions and answers

### Sesderma or Noche Y Dia: which is better?

For skin with dark spots, Noche Y Dia has a High Lovi fit and its products on this page are fragrance-free, whereas Sesderma also has a High fit with its Azelac RU [Serum](https://lovi.care/skincare/ca/ingredients/serum) but includes fragrance. Lovi rates Noche Y Dia as having a High fit for dry skin, compared to a Low fit for Sesderma.

[The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/) [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What is the difference between Sesderma and Noche Y Dia?

Noche Y Dia has a High Lovi fit for dry skin, whereas Sesderma has a Low fit for that skin type. Additionally, every product on the Noche Y Dia page lists no fragrance, while Sesderma includes fragrance in its Azelac RU Serum.

### Which is more affordable, Sesderma or Noche Y Dia?

The page facts do not provide pricing information for either Sesderma or Noche Y Dia, so it is not possible to determine which brand is more affordable.

### Which causes fewer breakouts, Sesderma or Noche Y Dia?

For acne-prone skin, Sesderma has an Average Lovi fit with its Azelac RU Serum, while Noche Y Dia also has an Average Lovi fit with its [Vitamin C](https://lovi.care/skincare/ca/ingredients/vitamin-c) Serum.

### How do the founding years and ownership of Sesderma and Noche Y Dia compare?

Sesderma was founded in Spain in 1989 and is owned by Grupo Sesderma since 2026, whereas Noche Y Dia was established earlier in 1965 in Spain and is owned by Laboratorios Ximart S.A.

### Which brand offers a serum with a High Lovi fit level for dry skin, Sesderma or Noche Y Dia?

Noche Y Dia offers a serum with a High Lovi fit level for dry skin, while Sesderma receives a Low Lovi fit level for dry skin on this page. Lovi rates the Vitamin C Serum from Noche Y Dia as High for dry skin, whereas the Azelac RU Serum from Sesderma is rated Low.

### Do both brands include fragrance in their featured serums, or is one fragrance-free?

Noche Y Dia is fragrance-free on this page, as every product lists no fragrance in its ingredients. Sesderma includes fragrance in its Azelac RU Serum.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/ca/brands/sesderma)
- Spanish skincare: [Noche Y Dia](https://lovi.care/skincare/ca/brands/noche-y-dia)

## More comparisons

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- [The Ordinary vs Noche Y Dia](https://lovi.care/skincare/ca/compare/the-ordinary-vs-noche-y-dia)
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- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-sesderma)
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- [Dr. Althea vs Sesderma](https://lovi.care/skincare/ca/compare/dr-althea-vs-sesderma)
- [Dr. Althea vs Noche Y Dia](https://lovi.care/skincare/ca/compare/dr-althea-vs-noche-y-dia)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/ca/compare/some-by-mi-vs-sesderma)
- [Some By Mi vs Noche Y Dia](https://lovi.care/skincare/ca/compare/some-by-mi-vs-noche-y-dia)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-noche-y-dia
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- Spain: https://lovi.care/skincare/es/compare/sesderma-vs-noche-y-dia
- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-noche-y-dia (this page)
- Australia: https://lovi.care/skincare/au/compare/sesderma-vs-noche-y-dia
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