# Sesderma vs BIOEFFECT

Page: https://lovi.care/skincare/ca/compare/sesderma-vs-bioeffect

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Sesderma and BIOEFFECT are two esteemed skincare lines celebrated for their targeted [serums](https://lovi.care/skincare/ca/ingredients/serum) and advanced formulas. The Spanish brand founded in 1989 and owned by Grupo Sesderma since 2026 relies on botanical [extracts](https://lovi.care/skincare/ca/ingredients/extract) and active compounds to refine skin texture and promote a radiant complexion, while the second maker provides refined care for daily routines. Both suit distinct needs, with the former suiting sensitive, hyperpigmented, and aging skin types best—such as acne-prone skin treated by the Azelac RU Serum—and the latter suiting mature skin types best, including acne-prone skin addressed by the EGF Serum. Ultimately, they differ in their heritage and specific ingredient approaches, giving users tailored options for their unique complexions.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Sesderma and BIOEFFECT products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg36edb3d500).

### Popular Sesderma vs BIOEFFECT products

#### BIOEFFECT

- [EGF Serum](https://lovi.care/skincare/ca/p/bioeffect/egf-serum/for/dry-skin) — Superior fit

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/ca/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit

### Sesderma vs BIOEFFECT [serums](https://lovi.care/skincare/ca/ingredients/serum) and treatments

#### BIOEFFECT

- [EGF Serum](https://lovi.care/skincare/ca/p/bioeffect/egf-serum/for/dry-skin) — Superior fit

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/ca/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit

## Questions and answers

### Sesderma or BIOEFFECT: which is better?

BIOEFFECT is a better match for dry skin and mature skin, where Lovi rates its EGF [Serum](https://lovi.care/skincare/ca/ingredients/serum) as Superior, while Sesderma's Azelac RU Serum only reaches a High fit for acne-prone skin and dark spots. Additionally, the products on this page from BIOEFFECT list no fragrance.

### What is the difference between Sesderma and BIOEFFECT?

BIOEFFECT offers fragrance-free products on this page and achieves a Superior Lovi fit for dry and mature skin, whereas Sesderma includes fragrance in its products on this page and is rated with a High Lovi fit for acne-prone skin and dark spots.

### Which is more affordable, Sesderma or BIOEFFECT?

The public Lovi page does not provide pricing or affordability information for either Sesderma or BIOEFFECT.

### Which causes fewer breakouts, Sesderma or BIOEFFECT?

BIOEFFECT EGF Serum has a High Lovi fit for acne-prone skin, while Sesderma Azelac RU Serum has an Average fit, making BIOEFFECT generally better for avoiding breakouts. Additionally, every product on the BIOEFFECT page lists no fragrance, whereas the Sesderma product contains fragrance.

### Which brand was founded earlier, Sesderma or BIOEFFECT?

Sesderma was founded earlier than BIOEFFECT, having started in Spain in 1989 compared to BIOEFFECT which was founded in 2010.

### Do products from Sesderma and BIOEFFECT contain fragrance?

BIOEFFECT products on this page list no fragrance in their ingredients, whereas the Azelac RU Serum from Sesderma contains fragrance.

### Which brand offers a serum for dry skin with a superior fit level?

BIOEFFECT offers a serum for dry skin with a superior fit level, specifically through its EGF Serum. The products on this page for BIOEFFECT are fragrance-free.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Sodium hyaluronate · Drug Delivery, 2017
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/ca/brands/sesderma)
- Skincare: [BIOEFFECT](https://lovi.care/skincare/ca/brands/bioeffect)

## More comparisons

- [SKIN1004 vs Sesderma](https://lovi.care/skincare/ca/compare/skin1004-vs-sesderma)
- [SKIN1004 vs BIOEFFECT](https://lovi.care/skincare/ca/compare/skin1004-vs-bioeffect)
- [Anua vs Sesderma](https://lovi.care/skincare/ca/compare/anua-vs-sesderma)
- [Anua vs BIOEFFECT](https://lovi.care/skincare/ca/compare/anua-vs-bioeffect)
- [Medicube vs Sesderma](https://lovi.care/skincare/ca/compare/medicube-vs-sesderma)
- [Medicube vs BIOEFFECT](https://lovi.care/skincare/ca/compare/medicube-vs-bioeffect)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/ca/compare/the-ordinary-vs-sesderma)
- [The Ordinary vs BIOEFFECT](https://lovi.care/skincare/ca/compare/the-ordinary-vs-bioeffect)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/ca/compare/beauty-of-joseon-vs-sesderma)
- [Beauty of Joseon vs BIOEFFECT](https://lovi.care/skincare/ca/compare/beauty-of-joseon-vs-bioeffect)
- [COSRX vs Sesderma](https://lovi.care/skincare/ca/compare/cosrx-vs-sesderma)
- [COSRX vs BIOEFFECT](https://lovi.care/skincare/ca/compare/cosrx-vs-bioeffect)
- [CeraVe vs Sesderma](https://lovi.care/skincare/ca/compare/cerave-vs-sesderma)
- [CeraVe vs BIOEFFECT](https://lovi.care/skincare/ca/compare/cerave-vs-bioeffect)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-sesderma)
- [La Roche-Posay vs BIOEFFECT](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-bioeffect)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/ca/compare/dr-althea-vs-sesderma)
- [Dr. Althea vs BIOEFFECT](https://lovi.care/skincare/ca/compare/dr-althea-vs-bioeffect)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/ca/compare/some-by-mi-vs-sesderma)
- [Some By Mi vs BIOEFFECT](https://lovi.care/skincare/ca/compare/some-by-mi-vs-bioeffect)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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