# Medik8 vs MAC

Page: https://lovi.care/skincare/ca/compare/medik8-vs-mac

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Medik8 and MAC are distinct beauty houses, with the British brand focusing on hyaluronic acid-powered [serums](https://lovi.care/skincare/ca/ingredients/serum), moisturizers, eye products, and toners, while the Canadian brand offers reliable daily moisturizers and makeup removers from balanced formulas. Medik8 suits dry and dry sensitive skin best, with standout items like the Surface Radiance Cleanse for acne-prone skin, the Oxy-R Peptides for dark spots, and the Total Moisture Daily Facial Cream for mature skin. Conversely, the Estée Lauder-owned brand suits balanced skin best, featuring targeted choices such as the Mineralize Timecheck Lotion for acne-prone skin, the Hyper Real Fresh Canvas Cleansing Oil for dark spots, and the Hyper Real Serumizer for mature skin. Ultimately, the former highlights targeted active ingredients, whereas the latter provides a calm and measured foundation for daily maintenance.

Medik8 is a British skincare brand founded in 2009 and owned by L'Oréal Groupe since 2025.

[loreal.com](https://www.loreal.com/en/press-release/group/l-oreal-groupe-to-acquire-a-majority-stake-in-medik8/) [medik8.com](https://www.medik8.com/pages/founders-story) [tracxn.com](https://tracxn.com/d/companies/medik8/__vqs3N9eL3EfvIq0IoeUPADts7CrlGbzm7kjy9M9QY8o)

MAC is a Canadian skincare brand founded in 1984 and owned by The Estée Lauder Companies Inc. since 1994.

[elcompanies.com](https://www.elcompanies.com/en-gb/our-brands/mac) [en.wikipedia.org](https://en.wikipedia.org/wiki/Est%C3%A9e_Lauder_Companies)

This page compares some of the most popular Medik8 and MAC products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pga9b0ce30c8).

### Popular Medik8 vs MAC products

#### Medik8

- [Liquid Peptides](https://lovi.care/skincare/ca/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [CA$133.00 at Amazon](https://www.amazon.ca/dp/B0DT1LYVZ6?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [CRYSTAL RETINAL 3](https://lovi.care/skincare/ca/p/medik8/crystal-retinal-3/for/mature-skin) — High fit — [CA$114.99 at Amazon](https://www.amazon.ca/dp/B0BHX7NYJG?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [C-Tetra Serum](https://lovi.care/skincare/ca/p/medik8/c-tetra-serum/for/dry-sensitive-skin) — Average fit — [CA$139.99 at Amazon](https://www.amazon.ca/dp/B0F8P1V9WQ?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Bakuchiol Peptides](https://lovi.care/skincare/ca/p/medik8/bakuchiol-peptides/for/dry-skin) — Superior fit — [CA$82.00 at Sephora](https://www.sephora.com/ca/en/product/bakuchiol-peptides-serum-P525907?skuId=3011251)
- [Crystal Retinal Ceramide Eye 3](https://lovi.care/skincare/ca/p/medik8/crystal-retinal-ceramide-eye-3/for/mature-skin) — High fit — [CA$76.00 at Sephora](https://www.sephora.com/ca/en/product/crystal-retinal-ceramide-eye-age-defying-night-eye-cream-P525999?skuId=3011160)
- [Oxy-R Peptides](https://lovi.care/skincare/ca/p/medik8/oxy-r-peptides/for/mature-skin) — Superior fit — [CA$94.00 at Amazon](https://www.amazon.ca/dp/B0CKCMLNRK?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Total Moisture Daily Facial Cream](https://lovi.care/skincare/ca/p/medik8/total-moisture-daily-facial-cream/for/mature-skin) — High fit — [CA$69.00 at Amazon](https://www.amazon.ca/dp/B0D714LX6K?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Hydr8 B5 Intense](https://lovi.care/skincare/ca/p/medik8/hydr8-b5-intense/for/dry-skin) — Superior fit — [CA$101.00 at Sephora](https://www.sephora.com/ca/en/product/hydr8-b5-intense-serum-P525952?skuId=3011178)

#### MAC

- [Hyper Real Serumizer](https://lovi.care/skincare/ca/p/mac/hyper-real-serumizer/for/dry-sensitive-skin) — High fit — [CA$86.93 at Amazon](https://www.amazon.ca/dp/B0BV14LWTN?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Mineralize Timecheck Lotion](https://lovi.care/skincare/ca/p/mac/mineralize-timecheck-lotion/for/dry-skin) — High fit
- [Hyper Real Fresh Canvas Cleansing Oil](https://lovi.care/skincare/ca/p/mac/hyper-real-fresh-canvas-cleansing-oil/for/dry-sensitive-skin) — High fit

## People Say

Medik8

MAC

- Hydration and Moisture Often Mentioned Mostly Mentioned “absorbs quickly — MAC Hyper Real Serumizer” “Absorbs in a snap — MAC Mineralize Timecheck Lotion” “Leaves skin feeling soft and supple, never tight. — MAC Hyper Real Fresh Canvas Cleansing Oil” “Restores moisture — Medik8 Liquid Peptides”
- Gentle and Non-Irritating Formulation Mostly Mentioned Often Mentioned “zero irritation or peeling — Medik8 CRYSTAL RETINAL 3” “only Vitamin C my sensitive skin can tolerate — Medik8 C-Tetra Serum” “Best retinol replacement — Medik8 Bakuchiol Peptides” “Does not cause breakouts — MAC Mineralize Timecheck Lotion”
- Makeup Compatibility and Base Rarely Noted Mostly Mentioned “foundation glides on — MAC Hyper Real Serumizer” “Sits beautifully under makeup — MAC Mineralize Timecheck Lotion” “layers well under sunscreen — Medik8 Total Moisture Daily Facial Cream”
- Brightening and Glow Often Mentioned Often Mentioned “I wake up glowing. It adds back that youthful bloom that I've lost. — Medik8 Sleep Glycolic” “unlocked a serious glow — Medik8 C-Tetra Serum” “immediate glow — Medik8 Super C Ferulic” “lit-from-within look — MAC Hyper Real Serumizer”
- Skin Plumping and Smoothing Sometimes Noted Often Mentioned “Reduces appearance of pores — MAC Mineralize Timecheck Lotion” “petal-soft skin — MAC Hyper Real Serumizer” “My skin was smoother, my skin texture felt more resurfaced. — Medik8 Sleep Glycolic”
- Lightweight and Elegant Texture Often Mentioned Often Mentioned “absorbed effortlessly — Medik8 Total Moisture Daily Facial Cream” “Absorbs fast — Medik8 Liquid Peptides” “Emulsifies beautifully and rinses off without a greasy film. — MAC Hyper Real Fresh Canvas Cleansing Oil”
- High Price Point Often Mentioned Mostly Mentioned “Expensive per bottle — Medik8 Liquid Peptides” “very expensive for amount — Medik8 CRYSTAL RETINAL 3” “hefty price tag — Medik8 C-Tetra Serum” “too expensive — MAC Hyper Real Serumizer”
- Caused Breakouts or Reactions Rarely Noted Sometimes Noted “made me break out constantly — Medik8 C-Tetra Serum” “caused breakouts — Medik8 Oxy-R Peptides” “caused me to breakout — Medik8 Total Moisture Daily Facial Cream” “caused acne — MAC Hyper Real Serumizer”

## Questions and answers

### Medik8 or MAC: which is better?

Medik8 stands out for its gentle, fragrance-free formulations and specialized targeted [serums](https://lovi.care/skincare/ca/ingredients/serum) that help with brightening and hydration, whereas MAC is better known for its makeup-compatible bases and lightweight moisturizers. Reviewers note that Medik8 products on this page often provide deep hydration, while MAC options frequently feature strong fragrances.

### What is the difference between Medik8 and MAC?

Medik8 stands out for its gentle, fragrance-free serums that help brighten skin and improve texture, whereas MAC features lightweight moisturizers and cleansing oils that often contain fragrance and focus on makeup compatibility. Reviewers note that Medik8 has a higher price point and can sometimes cause breakouts, while MAC products tend to have strong fragrance that may cause sensitivity.

### Medik8 or MAC: which moisturizer is better?

Medik8 is generally better for moisture because the products on this page, such as Hydr8 B5 Intense, achieve superior Lovi fit ratings for dry skin compared to MAC. MAC moisturizers feature strong fragrance, whereas Medik8 offers gentle, fragrance-free hydration options that help soothe the skin.

[Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/) [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which is more affordable, Medik8 or MAC?

Both Medik8 and MAC share a high price point as a common drawback noted by reviewers, so neither brand is more affordable.

### Which causes fewer breakouts, Medik8 or MAC?

Medik8 is noted for causing breakouts or reactions according to reviewer feedback on this page, whereas MAC does not share this drawback.

### Between Medik8 and MAC, which brand offers better brightening and glow benefits according to review themes?

Medik8 does better than MAC when it comes to brightening and glow. Reviewers often mention its brightening and glow benefits alongside its gentle, non-irritating formulas.

### How does the country and year of foundation differ between Medik8 and MAC?

Medik8 was founded in 2003 in the United Kingdom, whereas MAC was founded in 1984 in Canada.

### Which brand has more products that list no fragrance: Medik8 or MAC?

Medik8 has more products that list no fragrance on this page, with 11 out of 12 products being fragrance-free, compared to MAC which has 0 out of 3 fragrance-free products.

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Hyaluronic acid · Drug Delivery, 2017
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol vitamin e, Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation](https://pubmed.ncbi.nlm.nih.gov/18603326/) Ferulic acid · Journal of the American Academy of Dermatology, 2008
- [Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin](https://pubmed.ncbi.nlm.nih.gov/19146606/) Ferulic acid · Journal of Cosmetic Dermatology, 2008
- [Production and characterization of cosmetic nanoemulsions containing Opuntia ficus-indica (L.) mill extract as moisturizing agent](https://pubmed.ncbi.nlm.nih.gov/25648593/) Hydrolyzed opuntia ficus-indica flower extract · Molecules, 2015
- [Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica](https://pubmed.ncbi.nlm.nih.gov/25821823/) Hydrolyzed opuntia ficus-indica flower extract · BioMed Research International, 2015
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [Topical delivery of tetrahydrocurcumin lipid nanoparticles effectively inhibits skin inflammation: in vitro and in vivo study](https://pubmed.ncbi.nlm.nih.gov/29938544/) Tetrahydrodiferuloylmethane · Drug Development and Industrial Pharmacy, 2018
- [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalane · Scientific Reports, 2020
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Urea: a comprehensive review of the clinical literature](https://pubmed.ncbi.nlm.nih.gov/24314769/) Urea · Dermatology Online Journal, 2013
- [Effect of Camellia japonica oil on human type I procollagen production and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/17386986/) Camellia japonica seed oil · Journal of Ethnopharmacology, 2007
- [Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin](https://pubmed.ncbi.nlm.nih.gov/22584263/) Glyceryl glucoside · Skin Pharmacology and Physiology, 2012
- [Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/26061570/) Hydrolyzed opuntia ficus-indica flower extract · Journal of Medicinal Food, 2015
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Tocopherol vitamin e, Ferulic acid · Journal of Cosmetic Dermatology, 2020
- [Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation](https://pubmed.ncbi.nlm.nih.gov/21946069/) Hydroxyresveratrol · Food and Chemical Toxicology, 2011
- [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide](https://pubmed.ncbi.nlm.nih.gov/22916312/) Moisturizing factors nmf, Glyceryl glucoside · The Journal of Clinical and Aesthetic Dermatology, 2012
- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021
- [Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days](https://pubmed.ncbi.nlm.nih.gov/30924254/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2019
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Gluconolactone, Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin, Panthenol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Self-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol](https://pubmed.ncbi.nlm.nih.gov/26517086/) Paeonia albiflora flower extract · Medical Science Monitor, 2015
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Paeonia albiflora flower extract · Molecules, 2023
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects](https://pubmed.ncbi.nlm.nih.gov/32129554/) Vitamin e · Journal of Cosmetic Dermatology, 2020
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques](https://pubmed.ncbi.nlm.nih.gov/28385617/) Tetrahexyldecyl ascorbate · European Journal of Pharmaceutics and Biopharmaceutics, 2017
- [A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial](https://pubmed.ncbi.nlm.nih.gov/25914553/) Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019
- [Retaining Skin Barrier Function Properties of the Stratum Corneum with Components of the Natural Moisturizing Factor-A Randomized, Placebo-Controlled Double-Blind In Vivo Study](https://pubmed.ncbi.nlm.nih.gov/33809557/) Moisturizing factors nmf · Molecules, 2021
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations](https://pubmed.ncbi.nlm.nih.gov/35274433/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Subclinical cutaneous inflammation remained after permeability barrier disruption enhances UV sensitivity by altering ER stress responses and topical pseudoceramide prevents them](https://pubmed.ncbi.nlm.nih.gov/28631090/) Ceramide ng · Archives of Dermatological Research, 2017
- [Evaluation of moisturizing and irritation potential of sacha inchi oil](https://pubmed.ncbi.nlm.nih.gov/31441999/) Plukenetia volubilis seed oil · Journal of Cosmetic Dermatology, 2020
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines](https://pubmed.ncbi.nlm.nih.gov/19874316/) Undecylenoyl phenylalanine · Clinical and Experimental Dermatology, 2010
- [Partially purified paeoniflorin exerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin](https://pubmed.ncbi.nlm.nih.gov/16676123/) Paeonia albiflora flower extract · Journal of Cosmetic Science, 2006
- [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024
- [Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration](https://pubmed.ncbi.nlm.nih.gov/38611819/) Aloe barbadensis flower extract · Molecules, 2024
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial](https://pubmed.ncbi.nlm.nih.gov/40464749/) Ferulic acid · The Journal of Dermatological Treatment, 2025
- [Depth-dependent hydration dynamics in human skin: Vehicle-controlled efficacy assessment of a functional 10% urea plus NMF moisturizer by near-infrared confocal spectroscopic imaging (KOSIM IR) and capacitance method complemented by volunteer perception](https://pubmed.ncbi.nlm.nih.gov/35034387/) Moisturizing factors nmf · Skin Research and Technology, 2022
- [Effect of hydroxypropyl-β-cyclodextrin in fluid and semi-solid submicron emulsions on physiological skin parameters during regular in vivo application](https://pubmed.ncbi.nlm.nih.gov/33236374/) Cyclodextrin · International Journal of Cosmetic Science, 2021
- [Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis](https://pubmed.ncbi.nlm.nih.gov/37763018/) Yeast extract · Journal of Clinical Medicine, 2023
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Emulgels Containing Perilla frutescens Seed Oil, Moringa oleifera Seed Oil, and Mixed Seed Oil: Microemulsion and Safety Assessment](https://pubmed.ncbi.nlm.nih.gov/35745923/) Moringa oleifera seed oil · Polymers, 2022
- [Assessment of the efficacy and safety of a new complex skin cream in Asian women: A controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/28512843/) Hydroxyresveratrol · Journal of Cosmetic Dermatology, 2017
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Shea butter · Journal of Cosmetic Dermatology, 2022
- [Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid](https://pubmed.ncbi.nlm.nih.gov/20367666/) Pha polyhydroxy acid · Journal of Cosmetic Dermatology, 2010
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging](https://pubmed.ncbi.nlm.nih.gov/38525606/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties](https://pubmed.ncbi.nlm.nih.gov/41562471/) Bakuchiol · Skin Research and Technology, 2026
- [A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen](https://pubmed.ncbi.nlm.nih.gov/15002657/) Pha polyhydroxy acid · Cutis, 2004
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025
- [Preclinical Safety Evaluation of Dual Drug-Loaded Nanolipidic Carriers of Dissolvable Patches: In-Vitro and In-Vivo Safety Assessment](https://pubmed.ncbi.nlm.nih.gov/41186117/) Tetrahydrodiferuloylmethane · Molecular Pharmaceutics, 2025
- [Acai Oil-Based Organogel Containing Hyaluronic Acid for Topical Cosmetic: In Vitro and Ex Vivo Assessment](https://pubmed.ncbi.nlm.nih.gov/39339231/) Euterpe oleracea fruit extract · Pharmaceutics, 2024

## The brands

- British skincare: [Medik8](https://lovi.care/skincare/ca/brands/medik8)
- Canadian skincare: [MAC](https://lovi.care/skincare/ca/brands/mac)

## More comparisons

- [SKIN1004 vs Medik8](https://lovi.care/skincare/ca/compare/skin1004-vs-medik8)
- [SKIN1004 vs MAC](https://lovi.care/skincare/ca/compare/skin1004-vs-mac)
- [Anua vs Medik8](https://lovi.care/skincare/ca/compare/anua-vs-medik8)
- [Anua vs MAC](https://lovi.care/skincare/ca/compare/anua-vs-mac)
- [Medicube vs Medik8](https://lovi.care/skincare/ca/compare/medicube-vs-medik8)
- [Medicube vs MAC](https://lovi.care/skincare/ca/compare/medicube-vs-mac)
- [The Ordinary vs Medik8](https://lovi.care/skincare/ca/compare/the-ordinary-vs-medik8)
- [The Ordinary vs MAC](https://lovi.care/skincare/ca/compare/the-ordinary-vs-mac)
- [Beauty of Joseon vs Medik8](https://lovi.care/skincare/ca/compare/beauty-of-joseon-vs-medik8)
- [Beauty of Joseon vs MAC](https://lovi.care/skincare/ca/compare/beauty-of-joseon-vs-mac)
- [COSRX vs Medik8](https://lovi.care/skincare/ca/compare/cosrx-vs-medik8)
- [COSRX vs MAC](https://lovi.care/skincare/ca/compare/cosrx-vs-mac)
- [CeraVe vs Medik8](https://lovi.care/skincare/ca/compare/cerave-vs-medik8)
- [CeraVe vs MAC](https://lovi.care/skincare/ca/compare/cerave-vs-mac)
- [La Roche-Posay vs Medik8](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-medik8)
- [La Roche-Posay vs MAC](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-mac)
- [Dr. Althea vs Medik8](https://lovi.care/skincare/ca/compare/dr-althea-vs-medik8)
- [Dr. Althea vs MAC](https://lovi.care/skincare/ca/compare/dr-althea-vs-mac)
- [Some By Mi vs Medik8](https://lovi.care/skincare/ca/compare/some-by-mi-vs-medik8)
- [Some By Mi vs MAC](https://lovi.care/skincare/ca/compare/some-by-mi-vs-mac)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/medik8-vs-mac
- United Kingdom: https://lovi.care/skincare/uk/compare/medik8-vs-mac
- Ireland: https://lovi.care/skincare/ie/compare/medik8-vs-mac
- Germany: https://lovi.care/skincare/de/compare/medik8-vs-mac
- France: https://lovi.care/skincare/fr/compare/medik8-vs-mac
- Italy: https://lovi.care/skincare/it/compare/medik8-vs-mac
- Netherlands: https://lovi.care/skincare/nl/compare/medik8-vs-mac
- Spain: https://lovi.care/skincare/es/compare/medik8-vs-mac
- Canada: https://lovi.care/skincare/ca/compare/medik8-vs-mac (this page)
- Australia: https://lovi.care/skincare/au/compare/medik8-vs-mac
- Singapore: https://lovi.care/skincare/sg/compare/medik8-vs-mac
- Saudi Arabia: https://lovi.care/skincare/sa/compare/medik8-vs-mac
- United Arab Emirates: https://lovi.care/skincare/ae/compare/medik8-vs-mac