# ISDIN vs Azclear

Page: https://lovi.care/skincare/ca/compare/isdin-vs-azclear

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

ISDIN and Azclear are respected skincare labels offering thoughtful formulations designed to gently nurture the complexion. The Spanish house founded in 1975 provides elegant moisturizers, advanced sunscreens, restorative [serums](https://lovi.care/skincare/ca/ingredients/serum), and targeted eye products, whereas the alternative is deeply appreciated for its soothing serums. Both brands suit sensitive and acne-prone skin best, though the former also cares for dry skin and the latter supports reactive skin types. They differ primarily in their standout solutions, with the first offering Fusion [Water](https://lovi.care/skincare/ca/ingredients/water), Eryfotona Actinica, and K-Ox Eyes, and the second providing the Medicated Lotion.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

[puig.com](https://www.puig.com/en/newsroom/new-chapter-for-Isdin-Puig-to-assume-full-ownership/) [beautymatter.com](https://beautymatter.com/articles/puig-to-take-full-ownership-of-isdin-in-1-39-billion-deal) [uploads.puig.com](https://uploads.puig.com/uploads/Puig_NP_Sept_14_EN_fc21e2f47a.pdf)

This page compares some of the most popular ISDIN and Azclear products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg5b2e0b55d2).

### Popular ISDIN vs Azclear products

#### ISDIN

- [Eryfotona Actinica](https://lovi.care/skincare/ca/p/isdin/eryfotona-actinica/for/mature-skin) — Superior fit
- [Fusion Water](https://lovi.care/skincare/ca/p/isdin/fusion-water/for/dry-sensitive-skin) — Superior fit — [CA$69.99 at Amazon](https://www.amazon.ca/dp/B07B9KD2JF?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [K-Ox Eyes](https://lovi.care/skincare/ca/p/isdin/k-ox-eyes/for/dry-skin) — High fit — [CA$124.76 at Amazon](https://www.amazon.ca/dp/B01BMLQ4JQ?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Hyaluronic Concentrate](https://lovi.care/skincare/ca/p/isdin/hyaluronic-concentrate/for/sensitive-skin) — High fit
- [Hyaluronic Moisture](https://lovi.care/skincare/ca/p/isdin/hyaluronic-moisture/for/dry-sensitive-skin) — Average fit
- [Flavo-C Serum](https://lovi.care/skincare/ca/p/isdin/flavo-c-serum/for/sensitive-skin) — High fit — [CA$65.00 at Amazon](https://www.amazon.ca/dp/B075TH2GR2?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Uradin Lotion 10](https://lovi.care/skincare/ca/p/isdin/uradin-lotion-10/for/dry-skin) — High fit
- [Retinal Intense Serum](https://lovi.care/skincare/ca/p/isdin/retinal-intense-serum/for/acne-prone-skin) — High fit

#### Azclear

- [Medicated Lotion](https://lovi.care/skincare/ca/p/azclear/medicated-lotion/for/oily-acne-prone-skin) — High fit

## Questions and answers

### ISDIN or Azclear: which is better?

ISDIN is the better option for most shoppers, as the products on this page offer superior fits for dry, sensitive, and mature skin compared to Azclear's single fragrance-free medicated lotion. ISDIN features ultralight, makeup-friendly sunscreens and hydrating [serums](https://lovi.care/skincare/ca/ingredients/serum), though reviewers note a higher price point and some products contain fragrance.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/) [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What is the difference between ISDIN and Azclear?

ISDIN offers a broad range of products with fit levels reaching Superior for dry, sensitive, and dry sensitive skin, whereas Azclear features only a single medicated lotion on this page that helps oily acne-prone skin with a High fit level. Reviewers appreciate ISDIN for ultralight and makeup-friendly sunscreens, though some note a high price point and strong fragrance, while every Azclear product lists no fragrance.

### Which is more affordable, ISDIN or Azclear?

Azclear products on this page are generally more affordable, whereas reviewers often mention that ISDIN has a high price point.

### Which causes fewer breakouts, ISDIN or Azclear?

AzclearMedicated Lotion and the acne-targeted products on the ISDIN page both help manage breakouts, but ISDIN offers a much wider range of options for acne-prone skin.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### How do the origins and parent companies of ISDIN and Azclear differ?

ISDIN was founded in 1975 in Spain and is owned by Puig, whereas Azclear was founded in 2010 and is owned by Ego Pharmaceuticals.

### Which brand offers more fragrance-free options between ISDIN and Azclear?

Azclear offers more fragrance-free options because every product on this page lists no fragrance, whereas ISDIN has fragrance in 5 of its 8 products on this page.

### How does the Lovi fit level for oily acne-prone skin compare between ISDIN's Medicated Lotion and Azclear's products?

For oily acne-prone skin, Azclear's Medicated Lotion has a High Lovi fit level, whereas ISDIN's products on this page range from High to Caution.

## Research behind their key ingredients

- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Antioxidants · Drug Delivery, 2017
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate, Hyaluronic acid · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial](https://pubmed.ncbi.nlm.nih.gov/29416368/) Melatonin · Clinical, Cosmetic and Investigational Dermatology, 2018
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Inhibition of TRPV1 prevented skin irritancy induced by phenoxyethanol. A preliminary in vitro and in vivo study](https://pubmed.ncbi.nlm.nih.gov/27168163/) Phenoxyethanol · International Journal of Cosmetic Science, 2017
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study](https://pubmed.ncbi.nlm.nih.gov/36729399/) Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023
- [Comparison of methods for assessing photoprotection against ultraviolet A in vivo](https://pubmed.ncbi.nlm.nih.gov/3819071/) Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987
- [Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters](https://pubmed.ncbi.nlm.nih.gov/31437563/) Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters](https://pubmed.ncbi.nlm.nih.gov/40227214/) Octocrylene · Antioxidants, 2025
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection](https://pubmed.ncbi.nlm.nih.gov/36455708/) Butyl methoxydibenzoylmethane · European Journal of Pharmaceutical Sciences, 2023
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation](https://pubmed.ncbi.nlm.nih.gov/37074796/) Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl salicylate · Archives of Dermatological Research, 2024
- [The clinical efficacy of a new emulsion for acne and conspicuous facial pore amelioration](https://pubmed.ncbi.nlm.nih.gov/38140770/) Lens esculenta seed extract · Journal of Cosmetic Dermatology, 2024
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · International Journal of Cosmetic Science, 2026
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025

## The brands

- Spanish skincare: [ISDIN](https://lovi.care/skincare/ca/brands/isdin)
- Skincare: [Azclear](https://lovi.care/skincare/ca/brands/azclear)

## More comparisons

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- [Anua vs ISDIN](https://lovi.care/skincare/ca/compare/anua-vs-isdin)
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- [The Ordinary vs ISDIN](https://lovi.care/skincare/ca/compare/the-ordinary-vs-isdin)
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- [Beauty of Joseon vs ISDIN](https://lovi.care/skincare/ca/compare/beauty-of-joseon-vs-isdin)
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- [CeraVe vs ISDIN](https://lovi.care/skincare/ca/compare/cerave-vs-isdin)
- [CeraVe vs Azclear](https://lovi.care/skincare/ca/compare/cerave-vs-azclear)
- [La Roche-Posay vs ISDIN](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-isdin)
- [La Roche-Posay vs Azclear](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-azclear)
- [Dr. Althea vs ISDIN](https://lovi.care/skincare/ca/compare/dr-althea-vs-isdin)
- [Dr. Althea vs Azclear](https://lovi.care/skincare/ca/compare/dr-althea-vs-azclear)
- [Some By Mi vs ISDIN](https://lovi.care/skincare/ca/compare/some-by-mi-vs-isdin)
- [Some By Mi vs Azclear](https://lovi.care/skincare/ca/compare/some-by-mi-vs-azclear)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/isdin-vs-azclear
- United Kingdom: https://lovi.care/skincare/uk/compare/isdin-vs-azclear
- Ireland: https://lovi.care/skincare/ie/compare/isdin-vs-azclear
- Germany: https://lovi.care/skincare/de/compare/isdin-vs-azclear
- France: https://lovi.care/skincare/fr/compare/isdin-vs-azclear
- Italy: https://lovi.care/skincare/it/compare/isdin-vs-azclear
- Netherlands: https://lovi.care/skincare/nl/compare/isdin-vs-azclear
- Spain: https://lovi.care/skincare/es/compare/isdin-vs-azclear
- Canada: https://lovi.care/skincare/ca/compare/isdin-vs-azclear (this page)
- Australia: https://lovi.care/skincare/au/compare/isdin-vs-azclear
- Singapore: https://lovi.care/skincare/sg/compare/isdin-vs-azclear
- Saudi Arabia: https://lovi.care/skincare/sa/compare/isdin-vs-azclear
- United Arab Emirates: https://lovi.care/skincare/ae/compare/isdin-vs-azclear