# Hada Labo vs Mesoestetic

Page: https://lovi.care/skincare/ca/compare/hada-labo-vs-mesoestetic

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Hada Labo and Mesoestetic are popular skincare brands offering thoughtfully crafted formulas to support long-term skin health. The Japanese brand is known for its targeted toners, gentle makeup removers, and deeply hydrating moisturizers featuring key ingredients like [hyaluronic acid](https://lovi.care/skincare/ca/ingredients/hyaluronic-acid), whereas the Spanish brand is beloved for its targeted [serums](https://lovi.care/skincare/ca/ingredients/serum). Both suit sensitive skin best, while Hada Labo also accommodates dry, oily, and combination types, and Mesoestetic additionally targets mature and uneven skin. Ultimately, they differ in their specific product lineups and founding origins, with the former originating in 2004 and the latter in 1984.

Hada Labo is a Japanese skincare brand founded in 2004 and owned by Rohto Pharmaceutical Co., Ltd..

[en.wikipedia.org](https://en.wikipedia.org/wiki/Hada_Labo) [hadalabosa.co.za](https://hadalabosa.co.za/about-hada-labo/) [hadalabotokyo.pl](https://www.hadalabotokyo.pl/en/the-world-of-hada-labo/brand-history/)

Mesoestetic is a Spanish skincare brand founded in 1984 and owned by Mesoestetic Pharma Group, S.L..

[mesoestetic.com](https://www.mesoestetic.com/about-us) [tracxn.com](https://tracxn.com/d/companies/mesoestetic/__1eAnF7uALQzHII_So8HqZbHfSUJuilusj9hTisrG0tk)

This page compares some of the most popular Hada Labo and Mesoestetic products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg6565e18d2a).

### Popular Hada Labo vs Mesoestetic products

#### Hada Labo

- [Gokujyun Lotion](https://lovi.care/skincare/ca/p/hada-labo/gokujyun-lotion/for/dry-skin) — Superior fit
- [Gokujun Premium](https://lovi.care/skincare/ca/p/hada-labo/gokujun-premium/for/dry-skin) — Superior fit
- [Shirojyun Premium Whitening Lotion](https://lovi.care/skincare/ca/p/hada-labo/shirojyun-premium-whitening-lotion/for/dry-skin) — High fit
- [Gokujyun Cleansing Oil](https://lovi.care/skincare/ca/p/hada-labo/gokujyun-cleansing-oil/for/dry-skin) — Superior fit
- [Gokujyun Perfect Gel](https://lovi.care/skincare/ca/p/hada-labo/gokujyun-perfect-gel/for/dry-skin) — High fit
- [Premium Whitening Lotion (Light)](https://lovi.care/skincare/ca/p/hada-labo/premium-whitening-lotion-light/for/dry-sensitive-skin) — High fit

#### Mesoestetic

- [Cosmelan 2](https://lovi.care/skincare/ca/p/mesoestetic/cosmelan-2/for/acne-prone-skin) — Average fit

## Questions and answers

### Hada Labo or Mesoestetic: which is better?

Hada Labo is generally the better choice for everyday hydration because the products on this page offer superior to high Lovi fit levels for dry and sensitive skin types. Reviewers frequently highlight its deep moisturization and gentle, fragrance-free formulations, while [sodium hyaluronate](https://lovi.care/skincare/ca/ingredients/hyaluronic-acid) helps improve skin quality.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What is the difference between Hada Labo and Mesoestetic?

Hada Labo provides multiple hydrating products like toners and cleansers that Lovi rates as Superior or High for dry and sensitive skin, whereas Mesoestetic offers a single [serum](https://lovi.care/skincare/ca/ingredients/serum) that receives Low to Average fit levels across most skin types. Hyaluronic acid helps provide deep moisturization in Hada Labo items.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which is more affordable, Hada Labo or Mesoestetic?

Hada Labo is more affordable, offering popular hydrating products known for value and versatility.

### Which causes fewer breakouts, Hada Labo or Mesoestetic?

Hada Labo causes fewer breakouts on skin types where the products on this page achieve a fit level of High or Superior, while Mesoestetic has low fit ratings for sensitive and dry skin types.

### When was Hada Labo founded and where is its parent company based?

Hada Labo was founded in 2004, and its parent company, Rohto Pharmaceutical Co., Ltd., is based in Japan.

### How does the Lovi fit level of Hada Labo Gokujyun Lotion compare for dry skin versus oily skin?

For dry skin, Hada Labo Gokujyun Lotion receives a Superior Lovi fit level, whereas for oily skin it receives an Average fit level. Sodium hyaluronate helps deliver deep hydration and moisturization.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Do any products from Hada Labo or Mesoestetic contain added fragrance?

Every product on this page from both Hada Labo and Mesoestetic lists no added fragrance in its ingredients.

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramide · Scientific Reports, 2022
- [Preparation and characterization of a lecithin nanoemulsion as a topical delivery system](https://pubmed.ncbi.nlm.nih.gov/20652152/) Hydroxylated lecithin · Nanoscale Research Letters, 2009
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies](https://pubmed.ncbi.nlm.nih.gov/37681127/) Alpha-arbutin · Heliyon, 2023
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin](https://pubmed.ncbi.nlm.nih.gov/22236139/) Magnesium ascorbyl phosphate · Photochemistry and Photobiology, 2012
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [The anti-wrinkles properties of sodium acetylated hyaluronate](https://pubmed.ncbi.nlm.nih.gov/34708918/) Sodium acetylhyaluronate · Journal of Cosmetic Dermatology, 2022
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/27430380/) Diglycerin · Journal of Oleo Science, 2016
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides](https://pubmed.ncbi.nlm.nih.gov/36613524/) Glucosyl ceramide · International Journal of Molecular Sciences, 2022
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients](https://pubmed.ncbi.nlm.nih.gov/41628877/) 3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026
- [Combined Effect of Silybin and Sodium Acetylated Hyaluronate on UV-Induced Photoaging](https://pubmed.ncbi.nlm.nih.gov/42728863/) Sodium acetylhyaluronate · Skin Research and Technology, 2026

## The brands

- Japanese skincare: [Hada Labo](https://lovi.care/skincare/ca/brands/hada-labo)
- Spanish skincare: [Mesoestetic](https://lovi.care/skincare/ca/brands/mesoestetic)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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