# Galderma vs Natura Bissé Page: https://lovi.care/skincare/ca/compare/galderma-vs-natura-bisse The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada. Galderma and Natura Bissé are distinct skincare brands founded in Switzerland in 1981 and Spain in 1979, respectively. The Swiss brand offers targeted [serums](https://lovi.care/skincare/ca/ingredients/serum) like Epiduo Gel and Benzac AC for oily and combination skin, while the Spanish house is loved for luxurious moisturizers and advanced formulas that suit mature, dry, and sensitive skin best. Both makers provide carefully crafted treatments, though they differ entirely in their ingredients, textures, and ideal skin types. Galderma is a Swiss skincare brand founded in 1981 and owned by Galderma Group AG. [en.wikipedia.org](https://en.wikipedia.org/wiki/Galderma) Natura Bissé is a Spanish skincare brand founded in 1979 and owned by Natura Bissé International, S.A.. [naturabisse.com](https://www.naturabisse.com/int/en/our-story.html) [tracxn.com](https://tracxn.com/d/accelerator-incubator/ushopal/__yjGH7DKhQGNWnINKarEuFce6tilrPzGJv0PnASFLfpg) This page compares some of the most popular Galderma and Natura Bissé products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgcc73d5305b). ### Popular Galderma vs Natura Bissé products #### Natura Bissé - [Diamond Extreme](https://lovi.care/skincare/ca/p/natura-bisse/diamond-extreme/for/mature-skin) — Superior fit #### Galderma - [Epiduo Gel](https://lovi.care/skincare/ca/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit - [Benzac AC 5](https://lovi.care/skincare/ca/p/galderma/benzac-ac-5/for/oily-acne-prone-skin) — High fit — [CA$45.40 at Amazon](https://www.amazon.ca/dp/B0H7FDLC2T?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1) - [Benzac AC Mild Strength 2.5% Acne Gel](https://lovi.care/skincare/ca/p/galderma/benzac-ac-mild-strength-2-5-acne-gel/for/oily-acne-prone-skin) — High fit ## Questions and answers ### Galderma or Natura Bissé: which is better? Galderma is better for oily and acne-prone skin, as the products on this page have a High Lovi fit for those skin types, though reviewers note that severe dryness, peeling, and irritation may occur. [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/) [American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/) ### What is the difference between Galderma and Natura Bissé? Galderma focuses on acne-clearing [serums](https://lovi.care/skincare/ca/ingredients/serum) that fit oily and combination skin with a High Lovi rating, whereas Natura Bissé offers a moisturizer that achieves a Superior Lovi fit for mature skin. Reviewers note that Galderma products help clear acne but may cause severe dryness and peeling. [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/) [American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/) ### Which is more affordable, Galderma or Natura Bissé? The provided page and study facts do not contain pricing information to determine whether Galderma or Natura Bissé is more affordable. ### Which causes fewer breakouts, Galderma or Natura Bissé? Galderma is the better choice for acne because the products on this page are effective acne-clearing serums, whereas Natura Bissé offers only a moisturizer. Lovi gives Galderma a High fit for oily acne-prone skin. [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/) [American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/) ### Which brand uses fragrance in its products, Galderma or Natura Bissé? Natura Bissé uses fragrance in its products on this page, while every Galderma product on the page lists no fragrance. ### Which brand has a product with a Superior Lovi fit level for mature skin? Natura Bissé has a product with a Superior Lovi fit level for mature skin through its Diamond Extreme moisturizer. ### How does the routine for dry skin differ when using Galderma products? When following a Galderma-focused routine for dry skin, shoppers use hydrating and cleansing products alongside the brand's acne treatments like Benzac AC 5, while Lovi rates Epiduo Gel, Benzac AC 5, and Benzac AC Mild Strength as Low fits for dry skin. [The Cochrane Database of Systematic Reviews, 2020](https://pubmed.ncbi.nlm.nih.gov/32175593/) [American Journal of Clinical Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29549588/) ## Research behind their key ingredients - [Topical benzoyl peroxide for acne](https://pubmed.ncbi.nlm.nih.gov/32175593/) Benzoyl peroxide, Benzoyl peroxide 25mg g · The Cochrane Database of Systematic Reviews, 2020 - [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene · American Journal of Clinical Dermatology, 2018 - [Benzoyl peroxide treatment decreases Cutibacterium acnes in shoulder surgery, from skin incision until wound closure](https://pubmed.ncbi.nlm.nih.gov/33545336/) Benzoyl peroxide, Benzoyl peroxide 25mg g · Journal of Shoulder and Elbow Surgery, 2021 - [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017 - [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Benzoyl peroxide, Benzoyl peroxide 25mg g · American Journal of Clinical Dermatology, 2022 - [Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling](https://pubmed.ncbi.nlm.nih.gov/32098197/) Leontopodium alpinum leaf extract flower · Genes, 2020 - [Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells](https://pubmed.ncbi.nlm.nih.gov/23093820/) Leontopodium alpinum leaf extract flower · Mediators of Inflammation, 2012 - [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene · Archives of Dermatological Research, 2022 - [Development of Multifunctional Cosmetic Cream Using Bioactive Materials from Streptomyces sp. T65 with Synthesized Mesoporous Silica Particles SBA-15](https://pubmed.ncbi.nlm.nih.gov/32224894/) Silicon dioxide · Antioxidants, 2020 - [Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function](https://pubmed.ncbi.nlm.nih.gov/35409270/) Rosamarinus officinalis leaf extract rosemary leaf extract · International Journal of Molecular Sciences, 2022 - [Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection](https://pubmed.ncbi.nlm.nih.gov/32395645/) Silicon dioxide · Heliyon, 2020 - [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015 - [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023 - [Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: Results from two phase 3 double-blind, randomized, vehicle-controlled studies](https://pubmed.ncbi.nlm.nih.gov/37356627/) Benzoyl peroxide, Benzoyl peroxide 25mg g · Journal of the American Academy of Dermatology, 2023 - [Semi-Solid Dosage Forms Containing Pranoprofen-Loaded NLC as Topical Therapy for Local Inflammation: In Vitro, Ex Vivo and In Vivo Evaluation](https://pubmed.ncbi.nlm.nih.gov/37367119/) Carbomer 940 · Gels, 2023 - [Formulation and evaluation of exotic fat based cosmeceuticals for skin repair](https://pubmed.ncbi.nlm.nih.gov/20046792/) Mangifera indica seed butter · Indian Journal of Pharmaceutical Sciences, 2008 - [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023 - [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025 - [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026 ## The brands - Swiss skincare: [Galderma](https://lovi.care/skincare/ca/brands/galderma) - Spanish skincare: [Natura Bissé](https://lovi.care/skincare/ca/brands/natura-bisse) ## More comparisons - [SKIN1004 vs Galderma](https://lovi.care/skincare/ca/compare/skin1004-vs-galderma) - [SKIN1004 vs Natura Bissé](https://lovi.care/skincare/ca/compare/skin1004-vs-natura-bisse) - [Anua vs Galderma](https://lovi.care/skincare/ca/compare/anua-vs-galderma) - [Anua vs Natura Bissé](https://lovi.care/skincare/ca/compare/anua-vs-natura-bisse) - [Medicube vs Galderma](https://lovi.care/skincare/ca/compare/medicube-vs-galderma) - [Medicube vs Natura Bissé](https://lovi.care/skincare/ca/compare/medicube-vs-natura-bisse) - [The Ordinary vs Galderma](https://lovi.care/skincare/ca/compare/the-ordinary-vs-galderma) - [The Ordinary vs Natura Bissé](https://lovi.care/skincare/ca/compare/the-ordinary-vs-natura-bisse) - [Beauty of Joseon vs Galderma](https://lovi.care/skincare/ca/compare/beauty-of-joseon-vs-galderma) - [Beauty of Joseon vs Natura Bissé](https://lovi.care/skincare/ca/compare/beauty-of-joseon-vs-natura-bisse) - [COSRX vs Galderma](https://lovi.care/skincare/ca/compare/cosrx-vs-galderma) - [COSRX vs Natura Bissé](https://lovi.care/skincare/ca/compare/cosrx-vs-natura-bisse) - [CeraVe vs Galderma](https://lovi.care/skincare/ca/compare/cerave-vs-galderma) - [CeraVe vs Natura Bissé](https://lovi.care/skincare/ca/compare/cerave-vs-natura-bisse) - [La Roche-Posay vs Galderma](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-galderma) - [La Roche-Posay vs Natura Bissé](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-natura-bisse) - [Dr. Althea vs Galderma](https://lovi.care/skincare/ca/compare/dr-althea-vs-galderma) - [Dr. Althea vs Natura Bissé](https://lovi.care/skincare/ca/compare/dr-althea-vs-natura-bisse) - [Some By Mi vs Galderma](https://lovi.care/skincare/ca/compare/some-by-mi-vs-galderma) - [Some By Mi vs Natura Bissé](https://lovi.care/skincare/ca/compare/some-by-mi-vs-natura-bisse) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/galderma-vs-natura-bisse - United Kingdom: https://lovi.care/skincare/uk/compare/galderma-vs-natura-bisse - Ireland: https://lovi.care/skincare/ie/compare/galderma-vs-natura-bisse - Germany: https://lovi.care/skincare/de/compare/galderma-vs-natura-bisse - France: https://lovi.care/skincare/fr/compare/galderma-vs-natura-bisse - Italy: https://lovi.care/skincare/it/compare/galderma-vs-natura-bisse - Netherlands: https://lovi.care/skincare/nl/compare/galderma-vs-natura-bisse - Spain: https://lovi.care/skincare/es/compare/galderma-vs-natura-bisse - Canada: https://lovi.care/skincare/ca/compare/galderma-vs-natura-bisse (this page) - Australia: https://lovi.care/skincare/au/compare/galderma-vs-natura-bisse - Singapore: https://lovi.care/skincare/sg/compare/galderma-vs-natura-bisse - Saudi Arabia: https://lovi.care/skincare/sa/compare/galderma-vs-natura-bisse - United Arab Emirates: https://lovi.care/skincare/ae/compare/galderma-vs-natura-bisse