# Clarins vs Sesderma

Page: https://lovi.care/skincare/ca/compare/clarins-vs-sesderma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada.

Clarins and Sesderma are esteemed European skincare houses that offer distinct approaches to complexions needing targeted care. The French pioneer is celebrated for luxurious moisturizers, potent [serums](https://lovi.care/skincare/ca/ingredients/serum), soothing eye products, and gentle toners enriched with nourishing shea and hydrating squalane, which suit sensitive and dry sensitive skin best. Conversely, the Spanish innovator is beloved for advanced serums and meticulously engineered formulas tailored for sensitive, hyperpigmented, and aging skin types. While both brands address concerns like acne-prone skin through standout treatments such as the Double Serum Light Texture and the Azelac RU Serum, they differ in their heritage and foundational ingredients.

Clarins is a French skincare brand founded in 1954 and owned by Famille C (Groupe Clarins).

[groupeclarins.com](https://www.groupeclarins.com/our-governance/) [en.wikipedia.org](https://en.wikipedia.org/wiki/Clarins) [happi.com](https://www.happi.com/top-company-profile/clarins/)

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Clarins and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pge6cf93decb).

### Popular Clarins vs Sesderma products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/ca/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit

#### Clarins

- [Double Serum](https://lovi.care/skincare/ca/p/clarins/double-serum/for/sensitive-skin) — High fit — [CA$113.00 at Amazon](https://www.amazon.ca/dp/B0D6SL82YY?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Total Eye Lift](https://lovi.care/skincare/ca/p/clarins/total-eye-lift/for/mature-skin) — Superior fit — [CA$118.00 at Amazon](https://www.amazon.ca/dp/B0FH6RW755?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Double Serum Eye](https://lovi.care/skincare/ca/p/clarins/double-serum-eye/for/dry-sensitive-skin) — High fit — [CA$110.00 at Amazon](https://www.amazon.ca/dp/B0H7FHQL6D?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Cryo-Flash Cream-Mask](https://lovi.care/skincare/ca/p/clarins/cryo-flash-cream-mask/for/dry-sensitive-skin) — High fit — [CA$92.00 at Amazon](https://www.amazon.ca/dp/B0C63HWV6Z?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Beauty Flash Balm](https://lovi.care/skincare/ca/p/clarins/beauty-flash-balm/for/dry-skin) — Warning fit — [CA$59.00 at Amazon](https://www.amazon.ca/dp/B0B5VJVMVR?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Multi-Active Jour](https://lovi.care/skincare/ca/p/clarins/multi-active-jour/for/mature-skin) — Average fit — [CA$78.00 at Amazon](https://www.amazon.ca/dp/B0CRYRDKTF?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Double Serum Light Texture](https://lovi.care/skincare/ca/p/clarins/double-serum-light-texture/for/dry-sensitive-skin) — High fit — [CA$113.00 at Amazon](https://www.amazon.ca/dp/B0DQYQ5LJ5?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)
- [Extra-Firming Neck & Décolleté Cream](https://lovi.care/skincare/ca/p/clarins/extra-firming-neck-and-decollete-cream/for/dry-skin) — Average fit — [CA$112.00 at Amazon](https://www.amazon.ca/dp/B0H36XG1K7?tag=lovi-care-web-product01-20&linkCode=osi&th=1&psc=1)

## Questions and answers

### Clarins or Sesderma: which is better?

Clarins offers a much wider range of products on this page across different skin types and concerns, whereas Sesderma is represented by just one [serum](https://lovi.care/skincare/ca/ingredients/serum). Reviewers mention that Clarins provides hydrating and smoothing moisturizers, though some note a high price point and strong fragrance.

### What is the difference between Clarins and Sesderma?

Clarins offers a broad range of products on this page tailored for sensitive, dry sensitive, and mature skin, whereas Sesderma currently features only Azelac RU Serum.

### Which is more affordable, Clarins or Sesderma?

Reviewers on this page frequently mention a high price point for Clarins products.

### Which causes fewer breakouts, Clarins or Sesderma?

Clarins offers products on this page with varying breakout risks, while Sesderma features Azelac RU Serum, which is rated High for acne-prone skin.

### Which brand has been on the market longer, Clarins or Sesderma?

Clarins has been on the market longer, having been founded in France in 1954, whereas Sesderma was founded in Spain in 1989.

### How many products are listed on the page for Clarins compared to Sesderma?

Clarins has 24 products listed on the page, whereas Sesderma has only 1 product.

### Which brand's products predominantly contain fragrance according to the provided data?

Clarins has a large majority of products on this page that list fragrance, with 23 out of 24 containing it, while Sesderma also has all 1 of its products on this page listing fragrance.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review](https://pubmed.ncbi.nlm.nih.gov/30666070/) Aloe barbadensis leaf juice · Iranian Journal of Medical Sciences, 2019
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/19186973/) Acerola fruit extract, Ascorbyl glucoside · Journal of Periodontology, 2009
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomile extracts · International Journal of Molecular Medicine, 2016
- [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalane · Scientific Reports, 2020
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study](https://pubmed.ncbi.nlm.nih.gov/33966113/) Ascorbic acid · Clinical Oral Investigations, 2021
- [Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin](https://pubmed.ncbi.nlm.nih.gov/27349297/) Xylitol · Acta Dermato-venereologica, 2017
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin](https://pubmed.ncbi.nlm.nih.gov/25607907/) Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2015
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Two superior antioxidants: Ferulic acid and ascorbic acid in reducing signs of photoaging-A split-face comparative study](https://pubmed.ncbi.nlm.nih.gov/34877760/) Acerola fruit extract · Dermatologic Therapy, 2022
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [Mechanism of action and clinical benefits of colloidal oatmeal for dermatologic practice](https://pubmed.ncbi.nlm.nih.gov/20865844/) Avena sativa kernel extract · Journal of Drugs in Dermatology, 2010
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel leaf extract · Phytochemistry, 2001
- [Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects](https://pubmed.ncbi.nlm.nih.gov/32129554/) Vitamin e · Journal of Cosmetic Dermatology, 2020
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol](https://pubmed.ncbi.nlm.nih.gov/27391637/) Hexylresorcinol · Journal of Drugs in Dermatology, 2016
- [Colloidal Oatmeal <em>(Avena Sativa)</em> Improves Skin Barrier Through Multi-Therapy Activity](https://pubmed.ncbi.nlm.nih.gov/27272074/) Avena sativa kernel extract oat kernel extract · Journal of Drugs in Dermatology, 2016
- [Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide](https://pubmed.ncbi.nlm.nih.gov/34958693/) Hexylresorcinol · International Journal of Cosmetic Science, 2022
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations](https://pubmed.ncbi.nlm.nih.gov/35274433/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [In Vitro and Clinical Safety Assessment of the Multiple W/O/W Emulsion Based on the Active Ingredients from Rosmarinus officinalis L., Avena sativa L. and Linum usitatissimum L](https://pubmed.ncbi.nlm.nih.gov/34065623/) Avena sativa kernel extract oat kernel extract · Pharmaceutics, 2021
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- [In Vitro and Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Efficacy and Safety of Nine Antiacne Medicinal Plants](https://pubmed.ncbi.nlm.nih.gov/32695206/) Saponaria officinalis leaf extract · Evidence-based Complementary and Alternative Medicine, 2020
- [Skin improvement and stability of Echinacea purpurea dermatological formulations](https://pubmed.ncbi.nlm.nih.gov/20384903/) Echinacea purpurea extract · International Journal of Cosmetic Science, 2010
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [The impacts of sodium lauroyl sarcosinate in facial cleanser on facial skin microbiome and lipidome](https://pubmed.ncbi.nlm.nih.gov/37990616/) Sodium lauroyl sarcosinate · Journal of Cosmetic Dermatology, 2024
- [Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration](https://pubmed.ncbi.nlm.nih.gov/38611819/) Betaine · Molecules, 2024
- [Formulation of Ascorbic Acid and Betaine-based Therapeutic Deep Eutectic System for Enhanced Transdermal Delivery of Ascorbic Acid](https://pubmed.ncbi.nlm.nih.gov/38794349/) Betaine · Pharmaceutics, 2024
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Nanowire-based squalene oleogel repairs skin photoaging](https://pubmed.ncbi.nlm.nih.gov/40001122/) Squalane · Journal of Nanobiotechnology, 2025
- [Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores](https://pubmed.ncbi.nlm.nih.gov/17598025/) Sodium cocoyl isethionate · Journal of Cosmetic Science, 2007
- [Emulgels Containing Perilla frutescens Seed Oil, Moringa oleifera Seed Oil, and Mixed Seed Oil: Microemulsion and Safety Assessment](https://pubmed.ncbi.nlm.nih.gov/35745923/) Moringa oleifera seed extract · Polymers, 2022
- [Modulating effects of oatmeal extracts in the sodium lauryl sulfate skin irritancy model](https://pubmed.ncbi.nlm.nih.gov/11867969/) Avena sativa kernel extract oat kernel extract · Skin Pharmacology and Applied Skin Physiology, 2002
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance](https://pubmed.ncbi.nlm.nih.gov/36502500/) Hexylresorcinol · Archives of Dermatological Research, 2023
- [Combining Topical and Oral Botanicals for Skin Redness, Pigmentation, Sleep, and Mood: A Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/36431167/) Saffron extracts flower · Journal of Clinical Medicine, 2022
- [Moisturizing effect of stable cream containing Crocus sativus extracts](https://pubmed.ncbi.nlm.nih.gov/25362612/) Saffron extracts flower · Pakistan Journal of Pharmaceutical Sciences, 2014
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study](https://pubmed.ncbi.nlm.nih.gov/19146603/) Jojoba esters · Journal of Cosmetic Dermatology, 2008
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [In vitro, ex vivo and clinical approaches to evaluate the potential effect of Gentiana lutea extract on skin](https://pubmed.ncbi.nlm.nih.gov/37365865/) Gentiana lutea extract · International Journal of Cosmetic Science, 2023
- [Lemon Balm (Melissa officinalis L.) Leaf Extract Promotes Endo180 Production in Dermal Fibroblasts and has Antiwrinkle Effect on Human Skin](https://pubmed.ncbi.nlm.nih.gov/39888701/) Melissa officinalis leaf extract · Photodermatology, Photoimmunology & Photomedicine, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing](https://pubmed.ncbi.nlm.nih.gov/38685700/) Hexylresorcinol · International Journal of Cosmetic Science, 2024
- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) Ascorbyl glucoside · International Journal of Molecular Sciences, 2024
- [Cleansing lotion containing tamarind fruit pulp extract. II. Study of cumulative irritation effects in human](https://pubmed.ncbi.nlm.nih.gov/17760696/) Tamarindus indica pulp · Journal of Cosmetic Dermatology, 2007
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Microcirculation-Promoting Effect of Escin on Cutaneous Tissue via Gsk3β Down-Regulation](https://pubmed.ncbi.nlm.nih.gov/41150788/) Escin · Current Issues in Molecular Biology, 2025
- [Microcirculatory efficacy of topical treatment with aescin + essential phospholipids gel in venous insufficiency and hypertension: new clinical observations](https://pubmed.ncbi.nlm.nih.gov/15156249/) Escin · Angiology, 2004
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter, Saccharide isomerate, Shea butter · Lasers in Medical Science, 2025
- [Phytochemical characterization and antidermatophytic activity of a leaf extract from Mitracarpusscaber](https://pubmed.ncbi.nlm.nih.gov/40945880/) Mitracarpus scaber extract · Journal of Ethnopharmacology, 2026
- [A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study](https://pubmed.ncbi.nlm.nih.gov/41211697/) Saccharide isomerate · The Journal of Dermatological Treatment, 2025
- [Saccharide isomerate ameliorates cosmetic scalp conditions in a Chinese study population](https://pubmed.ncbi.nlm.nih.gov/35279940/) Saccharide isomerate · Journal of Cosmetic Dermatology, 2023
- [Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42147661/) Ascorbyl glucoside · Cureus, 2026
- [Two new lipoaminoacids with complementary modes of action: new prospects to fight out against skin aging](https://pubmed.ncbi.nlm.nih.gov/19732187/) Palmitoyl glycine · International Journal of Cosmetic Science, 2010

## The brands

- French skincare: [Clarins](https://lovi.care/skincare/ca/brands/clarins)
- Spanish skincare: [Sesderma](https://lovi.care/skincare/ca/brands/sesderma)

## More comparisons

- [SKIN1004 vs Clarins](https://lovi.care/skincare/ca/compare/skin1004-vs-clarins)
- [SKIN1004 vs Sesderma](https://lovi.care/skincare/ca/compare/skin1004-vs-sesderma)
- [Anua vs Clarins](https://lovi.care/skincare/ca/compare/anua-vs-clarins)
- [Anua vs Sesderma](https://lovi.care/skincare/ca/compare/anua-vs-sesderma)
- [Medicube vs Clarins](https://lovi.care/skincare/ca/compare/medicube-vs-clarins)
- [Medicube vs Sesderma](https://lovi.care/skincare/ca/compare/medicube-vs-sesderma)
- [The Ordinary vs Clarins](https://lovi.care/skincare/ca/compare/the-ordinary-vs-clarins)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/ca/compare/the-ordinary-vs-sesderma)
- [Beauty of Joseon vs Clarins](https://lovi.care/skincare/ca/compare/beauty-of-joseon-vs-clarins)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/ca/compare/beauty-of-joseon-vs-sesderma)
- [COSRX vs Clarins](https://lovi.care/skincare/ca/compare/cosrx-vs-clarins)
- [COSRX vs Sesderma](https://lovi.care/skincare/ca/compare/cosrx-vs-sesderma)
- [CeraVe vs Clarins](https://lovi.care/skincare/ca/compare/cerave-vs-clarins)
- [CeraVe vs Sesderma](https://lovi.care/skincare/ca/compare/cerave-vs-sesderma)
- [La Roche-Posay vs Clarins](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-clarins)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-sesderma)
- [Dr. Althea vs Clarins](https://lovi.care/skincare/ca/compare/dr-althea-vs-clarins)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/ca/compare/dr-althea-vs-sesderma)
- [Some By Mi vs Clarins](https://lovi.care/skincare/ca/compare/some-by-mi-vs-clarins)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/ca/compare/some-by-mi-vs-sesderma)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/clarins-vs-sesderma
- United Kingdom: https://lovi.care/skincare/uk/compare/clarins-vs-sesderma
- Ireland: https://lovi.care/skincare/ie/compare/clarins-vs-sesderma
- Germany: https://lovi.care/skincare/de/compare/clarins-vs-sesderma
- France: https://lovi.care/skincare/fr/compare/clarins-vs-sesderma
- Italy: https://lovi.care/skincare/it/compare/clarins-vs-sesderma
- Netherlands: https://lovi.care/skincare/nl/compare/clarins-vs-sesderma
- Spain: https://lovi.care/skincare/es/compare/clarins-vs-sesderma
- Canada: https://lovi.care/skincare/ca/compare/clarins-vs-sesderma (this page)
- Australia: https://lovi.care/skincare/au/compare/clarins-vs-sesderma
- Singapore: https://lovi.care/skincare/sg/compare/clarins-vs-sesderma
- Saudi Arabia: https://lovi.care/skincare/sa/compare/clarins-vs-sesderma
- United Arab Emirates: https://lovi.care/skincare/ae/compare/clarins-vs-sesderma